Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation

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Standard

Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation. / Modin, Daniel; Sengeløv, Morten; Jørgensen, Peter Godsk; Bruun, Niels Eske; Olsen, Flemming Javier; Dons, Maria; Fritz Hansen, Thomas; Jensen, Jan Skov; Biering-Sørensen, Tor.

I: E S C Heart Failure, Bind 5, Nr. 2, 2018, s. 311-318.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Modin, D, Sengeløv, M, Jørgensen, PG, Bruun, NE, Olsen, FJ, Dons, M, Fritz Hansen, T, Jensen, JS & Biering-Sørensen, T 2018, 'Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation', E S C Heart Failure, bind 5, nr. 2, s. 311-318. https://doi.org/10.1002/ehf2.12220

APA

Modin, D., Sengeløv, M., Jørgensen, P. G., Bruun, N. E., Olsen, F. J., Dons, M., Fritz Hansen, T., Jensen, J. S., & Biering-Sørensen, T. (2018). Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation. E S C Heart Failure, 5(2), 311-318. https://doi.org/10.1002/ehf2.12220

Vancouver

Modin D, Sengeløv M, Jørgensen PG, Bruun NE, Olsen FJ, Dons M o.a. Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation. E S C Heart Failure. 2018;5(2):311-318. https://doi.org/10.1002/ehf2.12220

Author

Modin, Daniel ; Sengeløv, Morten ; Jørgensen, Peter Godsk ; Bruun, Niels Eske ; Olsen, Flemming Javier ; Dons, Maria ; Fritz Hansen, Thomas ; Jensen, Jan Skov ; Biering-Sørensen, Tor. / Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation. I: E S C Heart Failure. 2018 ; Bind 5, Nr. 2. s. 311-318.

Bibtex

@article{cfdd5f0802ad4f979240b495b68214e9,
title = "Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation",
abstract = "AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination.METHODS AND RESULTS: Echocardiograms from 151 patients with HFrEF and AF during examination were analysed offline. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments obtained from three apical views. GLS was indexed with the square root of the RR interval {GLSc = GLS/[RR^(1/2)]}. Endpoint was all-cause mortality. During a median follow-up of 2.7 years, 40 patients (26.5%) died. Neither uncorrected GLS (P = 0.056) nor left ventricular ejection fraction (P = 0.053) was significantly associated with all-cause mortality. After RR^(1/2) indexation, GLSc became a significant predictor of all-cause mortality (hazard ratio 1.16, 95% confidence interval 1.02-1.22, P = 0.014, per %/s^(1/2) decrease). GLSc remained an independent predictor of mortality after multivariable adjustment (age, sex, mean heart rate, mean arterial blood pressure, left atrial volume index, and E/e') (hazard ratio 1.17, 95% confidence interval 1.05-1.31, P = 0.005 per %/s^(1/2) decrease).CONCLUSIONS: Decreasing {GLSc = GLS/[RR^(1/2)]}, but not uncorrected GLS nor left ventricular ejection fraction, was significantly associated with increased risk of all-cause mortality in HFrEF patients with AF and remained an independent predictor after multivariable adjustment.",
keywords = "Aged, Atrial Fibrillation/complications, Cause of Death/trends, Denmark/epidemiology, Echocardiography, Electrocardiography, Female, Follow-Up Studies, Heart Failure, Systolic/complications, Heart Ventricles/diagnostic imaging, Humans, Male, Myocardial Contraction/physiology, Prognosis, Retrospective Studies, Risk Assessment, Stroke Volume/physiology, Survival Rate/trends, Ventricular Function, Left",
author = "Daniel Modin and Morten Sengel{\o}v and J{\o}rgensen, {Peter Godsk} and Bruun, {Niels Eske} and Olsen, {Flemming Javier} and Maria Dons and {Fritz Hansen}, Thomas and Jensen, {Jan Skov} and Tor Biering-S{\o}rensen",
note = "{\textcopyright} 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.",
year = "2018",
doi = "10.1002/ehf2.12220",
language = "English",
volume = "5",
pages = "311--318",
journal = "E S C Heart Failure",
issn = "2055-5822",
publisher = "JohnWiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation

AU - Modin, Daniel

AU - Sengeløv, Morten

AU - Jørgensen, Peter Godsk

AU - Bruun, Niels Eske

AU - Olsen, Flemming Javier

AU - Dons, Maria

AU - Fritz Hansen, Thomas

AU - Jensen, Jan Skov

AU - Biering-Sørensen, Tor

N1 - © 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

PY - 2018

Y1 - 2018

N2 - AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination.METHODS AND RESULTS: Echocardiograms from 151 patients with HFrEF and AF during examination were analysed offline. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments obtained from three apical views. GLS was indexed with the square root of the RR interval {GLSc = GLS/[RR^(1/2)]}. Endpoint was all-cause mortality. During a median follow-up of 2.7 years, 40 patients (26.5%) died. Neither uncorrected GLS (P = 0.056) nor left ventricular ejection fraction (P = 0.053) was significantly associated with all-cause mortality. After RR^(1/2) indexation, GLSc became a significant predictor of all-cause mortality (hazard ratio 1.16, 95% confidence interval 1.02-1.22, P = 0.014, per %/s^(1/2) decrease). GLSc remained an independent predictor of mortality after multivariable adjustment (age, sex, mean heart rate, mean arterial blood pressure, left atrial volume index, and E/e') (hazard ratio 1.17, 95% confidence interval 1.05-1.31, P = 0.005 per %/s^(1/2) decrease).CONCLUSIONS: Decreasing {GLSc = GLS/[RR^(1/2)]}, but not uncorrected GLS nor left ventricular ejection fraction, was significantly associated with increased risk of all-cause mortality in HFrEF patients with AF and remained an independent predictor after multivariable adjustment.

AB - AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination.METHODS AND RESULTS: Echocardiograms from 151 patients with HFrEF and AF during examination were analysed offline. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments obtained from three apical views. GLS was indexed with the square root of the RR interval {GLSc = GLS/[RR^(1/2)]}. Endpoint was all-cause mortality. During a median follow-up of 2.7 years, 40 patients (26.5%) died. Neither uncorrected GLS (P = 0.056) nor left ventricular ejection fraction (P = 0.053) was significantly associated with all-cause mortality. After RR^(1/2) indexation, GLSc became a significant predictor of all-cause mortality (hazard ratio 1.16, 95% confidence interval 1.02-1.22, P = 0.014, per %/s^(1/2) decrease). GLSc remained an independent predictor of mortality after multivariable adjustment (age, sex, mean heart rate, mean arterial blood pressure, left atrial volume index, and E/e') (hazard ratio 1.17, 95% confidence interval 1.05-1.31, P = 0.005 per %/s^(1/2) decrease).CONCLUSIONS: Decreasing {GLSc = GLS/[RR^(1/2)]}, but not uncorrected GLS nor left ventricular ejection fraction, was significantly associated with increased risk of all-cause mortality in HFrEF patients with AF and remained an independent predictor after multivariable adjustment.

KW - Aged

KW - Atrial Fibrillation/complications

KW - Cause of Death/trends

KW - Denmark/epidemiology

KW - Echocardiography

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Heart Failure, Systolic/complications

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Male

KW - Myocardial Contraction/physiology

KW - Prognosis

KW - Retrospective Studies

KW - Risk Assessment

KW - Stroke Volume/physiology

KW - Survival Rate/trends

KW - Ventricular Function, Left

U2 - 10.1002/ehf2.12220

DO - 10.1002/ehf2.12220

M3 - Journal article

C2 - 29024533

VL - 5

SP - 311

EP - 318

JO - E S C Heart Failure

JF - E S C Heart Failure

SN - 2055-5822

IS - 2

ER -

ID: 213965209