GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications. / Stensen, Signe; Gasbjerg, Lærke Smidt; Helsted, Mads Marstrand; Hartmann, Bolette; Christensen, Mikkel Bring; Knop, Filip Krag.

I: Peptides, Bind 125, 170197, 2020.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Stensen, S, Gasbjerg, LS, Helsted, MM, Hartmann, B, Christensen, MB & Knop, FK 2020, 'GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications', Peptides, bind 125, 170197. https://doi.org/10.1016/j.peptides.2019.170197

APA

Stensen, S., Gasbjerg, L. S., Helsted, M. M., Hartmann, B., Christensen, M. B., & Knop, F. K. (2020). GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications. Peptides, 125, [170197]. https://doi.org/10.1016/j.peptides.2019.170197

Vancouver

Stensen S, Gasbjerg LS, Helsted MM, Hartmann B, Christensen MB, Knop FK. GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications. Peptides. 2020;125. 170197. https://doi.org/10.1016/j.peptides.2019.170197

Author

Stensen, Signe ; Gasbjerg, Lærke Smidt ; Helsted, Mads Marstrand ; Hartmann, Bolette ; Christensen, Mikkel Bring ; Knop, Filip Krag. / GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications. I: Peptides. 2020 ; Bind 125.

Bibtex

@article{4de2cbcc3ad14008a4820d79857dc059,
title = "GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications",
abstract = "The influence by gut-derived hormones on bone remodelling appears increasingly important as research on the enteroendocrine-osseous axis accelerates. Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut and potentiates insulin secretion in a glucose-dependent manner. GIP has, like the two other gut-derived hormones, glucagon-like peptide 1 and glucagon-like peptide 2, been shown to affect bone remodelling as part of the enteroendocrine-osseous axis. Observational studies have shown that a mutation in the GIP receptor causing reduced receptor signalling leads to lower bone mineral density and increased fracture risk. Rodent as well as human studies have shown that GIP causes serum levels of the bone resorption marker carboxy-terminal type 1 collagen crosslinks to decline. GIP may also increase bone formation indicating a potential uncoupling of bone resorption and formation. Here, we review past and recent discoveries elucidating the enteroendocrine-osseous axis with a special focus on GIP.",
keywords = "Enteroendocrine-osseous axis, GIP, Gut-bone axis",
author = "Signe Stensen and Gasbjerg, {L{\ae}rke Smidt} and Helsted, {Mads Marstrand} and Bolette Hartmann and Christensen, {Mikkel Bring} and Knop, {Filip Krag}",
year = "2020",
doi = "10.1016/j.peptides.2019.170197",
language = "English",
volume = "125",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - GIP and the gut-bone axis – Physiological, pathophysiological and potential therapeutic implications

AU - Stensen, Signe

AU - Gasbjerg, Lærke Smidt

AU - Helsted, Mads Marstrand

AU - Hartmann, Bolette

AU - Christensen, Mikkel Bring

AU - Knop, Filip Krag

PY - 2020

Y1 - 2020

N2 - The influence by gut-derived hormones on bone remodelling appears increasingly important as research on the enteroendocrine-osseous axis accelerates. Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut and potentiates insulin secretion in a glucose-dependent manner. GIP has, like the two other gut-derived hormones, glucagon-like peptide 1 and glucagon-like peptide 2, been shown to affect bone remodelling as part of the enteroendocrine-osseous axis. Observational studies have shown that a mutation in the GIP receptor causing reduced receptor signalling leads to lower bone mineral density and increased fracture risk. Rodent as well as human studies have shown that GIP causes serum levels of the bone resorption marker carboxy-terminal type 1 collagen crosslinks to decline. GIP may also increase bone formation indicating a potential uncoupling of bone resorption and formation. Here, we review past and recent discoveries elucidating the enteroendocrine-osseous axis with a special focus on GIP.

AB - The influence by gut-derived hormones on bone remodelling appears increasingly important as research on the enteroendocrine-osseous axis accelerates. Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut and potentiates insulin secretion in a glucose-dependent manner. GIP has, like the two other gut-derived hormones, glucagon-like peptide 1 and glucagon-like peptide 2, been shown to affect bone remodelling as part of the enteroendocrine-osseous axis. Observational studies have shown that a mutation in the GIP receptor causing reduced receptor signalling leads to lower bone mineral density and increased fracture risk. Rodent as well as human studies have shown that GIP causes serum levels of the bone resorption marker carboxy-terminal type 1 collagen crosslinks to decline. GIP may also increase bone formation indicating a potential uncoupling of bone resorption and formation. Here, we review past and recent discoveries elucidating the enteroendocrine-osseous axis with a special focus on GIP.

KW - Enteroendocrine-osseous axis

KW - GIP

KW - Gut-bone axis

U2 - 10.1016/j.peptides.2019.170197

DO - 10.1016/j.peptides.2019.170197

M3 - Review

C2 - 31715213

AN - SCOPUS:85075837309

VL - 125

JO - Peptides

JF - Peptides

SN - 0196-9781

M1 - 170197

ER -

ID: 238434646