Giant glial cell: new insight through mechanism-based modeling

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  • D E Postnov
  • L S Ryazanova
  • Nadezda Brazhe
  • Alexey Brazhe
  • G V Maximov
  • Erik Mosekilde
  • Sosnovtseva, Olga
The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.
OriginalsprogEngelsk
TidsskriftJournal of Biological Physics
Vol/bind34
Udgave nummer3-4
Sider (fra-til)441-57
Antal sider17
ISSN0092-0606
DOI
StatusUdgivet - 1 aug. 2008

ID: 33812338