Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts

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Standard

Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts. / Christensen, Esben; Henriksen, Jonas R.; Jorgensen, Jesper T.; Amitay, Yasmine; Shmeeda, Hilary; Gabizon, Alberto A.; Kjaer, Andreas; Andresen, Thomas L.; Hansen, Anders E.

I: International Journal of Nanomedicine, Bind 13, 2018, s. 7647-7656.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt

Harvard

Christensen, E, Henriksen, JR, Jorgensen, JT, Amitay, Y, Shmeeda, H, Gabizon, AA, Kjaer, A, Andresen, TL & Hansen, AE 2018, 'Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts', International Journal of Nanomedicine, bind 13, s. 7647-7656. https://doi.org/10.2147/IJN.S182579

APA

Christensen, E., Henriksen, J. R., Jorgensen, J. T., Amitay, Y., Shmeeda, H., Gabizon, A. A., Kjaer, A., Andresen, T. L., & Hansen, A. E. (2018). Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts. International Journal of Nanomedicine, 13, 7647-7656. https://doi.org/10.2147/IJN.S182579

Vancouver

Christensen E, Henriksen JR, Jorgensen JT, Amitay Y, Shmeeda H, Gabizon AA o.a. Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts. International Journal of Nanomedicine. 2018;13:7647-7656. https://doi.org/10.2147/IJN.S182579

Author

Christensen, Esben ; Henriksen, Jonas R. ; Jorgensen, Jesper T. ; Amitay, Yasmine ; Shmeeda, Hilary ; Gabizon, Alberto A. ; Kjaer, Andreas ; Andresen, Thomas L. ; Hansen, Anders E. / Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts. I: International Journal of Nanomedicine. 2018 ; Bind 13. s. 7647-7656.

Bibtex

@article{28ba913a7330478dad3c546d6a6e382c,
title = "Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts",
abstract = "Background: Active, ligand-mediated, targeting of functionalized liposomes to folate receptors (FRs) overexpressed on cancer cells could potentially improve drug delivery and specificity. Studies on folate-targeting liposomes (FTLs) have, however, yielded varying results and generally fail to display a clear benefit of FR targeting. Method: Tumor accumulating potential of FTLs and NTLs were investigated in a FR overexpressing xenograft model by positron emission tomography/computed tomography imaging. Results: Tumors displayed significantly lower activity of FTLs than NTLs. Furthermore, FTLs displayed worse circulating properties and increased liver-accumulation than NTLs. Conclusion: This study underlines that long-circulating properties of liposomes must be achieved to take advantage of EPR-dependent tumor accumulation which may be lost by functionalization. FR-functionalization negatively affected both tumor accumulation and circulation properties.",
keywords = "liposomes, folate, cancer, imaging, PET, EPR",
author = "Esben Christensen and Henriksen, {Jonas R.} and Jorgensen, {Jesper T.} and Yasmine Amitay and Hilary Shmeeda and Gabizon, {Alberto A.} and Andreas Kjaer and Andresen, {Thomas L.} and Hansen, {Anders E.}",
year = "2018",
doi = "10.2147/IJN.S182579",
language = "English",
volume = "13",
pages = "7647--7656",
journal = "International Journal of Nanomedicine",
issn = "1176-9114",
publisher = "Dove Press Ltd",

}

RIS

TY - JOUR

T1 - Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts

AU - Christensen, Esben

AU - Henriksen, Jonas R.

AU - Jorgensen, Jesper T.

AU - Amitay, Yasmine

AU - Shmeeda, Hilary

AU - Gabizon, Alberto A.

AU - Kjaer, Andreas

AU - Andresen, Thomas L.

AU - Hansen, Anders E.

PY - 2018

Y1 - 2018

N2 - Background: Active, ligand-mediated, targeting of functionalized liposomes to folate receptors (FRs) overexpressed on cancer cells could potentially improve drug delivery and specificity. Studies on folate-targeting liposomes (FTLs) have, however, yielded varying results and generally fail to display a clear benefit of FR targeting. Method: Tumor accumulating potential of FTLs and NTLs were investigated in a FR overexpressing xenograft model by positron emission tomography/computed tomography imaging. Results: Tumors displayed significantly lower activity of FTLs than NTLs. Furthermore, FTLs displayed worse circulating properties and increased liver-accumulation than NTLs. Conclusion: This study underlines that long-circulating properties of liposomes must be achieved to take advantage of EPR-dependent tumor accumulation which may be lost by functionalization. FR-functionalization negatively affected both tumor accumulation and circulation properties.

AB - Background: Active, ligand-mediated, targeting of functionalized liposomes to folate receptors (FRs) overexpressed on cancer cells could potentially improve drug delivery and specificity. Studies on folate-targeting liposomes (FTLs) have, however, yielded varying results and generally fail to display a clear benefit of FR targeting. Method: Tumor accumulating potential of FTLs and NTLs were investigated in a FR overexpressing xenograft model by positron emission tomography/computed tomography imaging. Results: Tumors displayed significantly lower activity of FTLs than NTLs. Furthermore, FTLs displayed worse circulating properties and increased liver-accumulation than NTLs. Conclusion: This study underlines that long-circulating properties of liposomes must be achieved to take advantage of EPR-dependent tumor accumulation which may be lost by functionalization. FR-functionalization negatively affected both tumor accumulation and circulation properties.

KW - liposomes

KW - folate

KW - cancer

KW - imaging

KW - PET

KW - EPR

U2 - 10.2147/IJN.S182579

DO - 10.2147/IJN.S182579

M3 - Journal article

C2 - 30538449

VL - 13

SP - 7647

EP - 7656

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

SN - 1176-9114

ER -

ID: 209682245