Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT

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Standard

Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT. / Ripa, Rasmus Sejersten; Knudsen, Andreas; Hag, Anne Mette Fisker; Lebech, Anne-Mette; Loft, Annika; Keller, Sune Høgild; Hansen, Adam Espe; von Benzon, Eric; Højgaard, Liselotte; Kjær, Andreas.

I: American Journal of Nuclear Medicine and Molecular Imaging, Bind 3, Nr. 4, 2013, s. 361-371.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ripa, RS, Knudsen, A, Hag, AMF, Lebech, A-M, Loft, A, Keller, SH, Hansen, AE, von Benzon, E, Højgaard, L & Kjær, A 2013, 'Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT' American Journal of Nuclear Medicine and Molecular Imaging, bind 3, nr. 4, s. 361-371.

APA

Ripa, R. S., Knudsen, A., Hag, A. M. F., Lebech, A-M., Loft, A., Keller, S. H., ... Kjær, A. (2013). Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT. American Journal of Nuclear Medicine and Molecular Imaging, 3(4), 361-371.

Vancouver

Ripa RS, Knudsen A, Hag AMF, Lebech A-M, Loft A, Keller SH o.a. Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT. American Journal of Nuclear Medicine and Molecular Imaging. 2013;3(4):361-371.

Author

Ripa, Rasmus Sejersten ; Knudsen, Andreas ; Hag, Anne Mette Fisker ; Lebech, Anne-Mette ; Loft, Annika ; Keller, Sune Høgild ; Hansen, Adam Espe ; von Benzon, Eric ; Højgaard, Liselotte ; Kjær, Andreas. / Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT. I: American Journal of Nuclear Medicine and Molecular Imaging. 2013 ; Bind 3, Nr. 4. s. 361-371.

Bibtex

@article{16ca989273e44d31925fe87ab765c668,
title = "Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT",
abstract = "The study aimed at comparing PET/MR to PET/CT for imaging the carotid arteries in patients with known increased risk of atherosclerosis. Six HIV-positive men underwent sequential PET/MR and PET/CT of the carotid arteries after injection of 400 MBq of 18F-FDG. PET/MR was performed a median of 131 min after injection. Subsequently, PET/CT was performed. Regions of interest (ROI) were drawn slice by slice to include the carotid arteries and standardized uptake values (SUV) were calculated from both datasets independently. Quantitative comparison of 18F-FDG uptake revealed a high congruence between PET data acquired using the PET/MR system compared to the PET/CT system. The mean difference for SUVmean was -0.18 (p < 0.001) and -0.14 for SUVmax (p < 0.001) indicating a small but significant bias towards lower values using the PET/MR system. The 95{\%} limits of agreement were -0.55 to 0.20 for SUVmean and -0.93 to 0.65 for SUVmax. The image quality of the PET/MR allowed for delineation of the carotid vessel wall. The correlations between 18F-FDG uptake from ROI including both vessel wall and vessel lumen to ROI including only the wall were strong (r = 0.98 for SUVmean and r = 1.00 for SUVmax) indicating that the luminal 18F-FDG content had minimal influence on the values. The study shows for the first time that simultaneous PET/MR of the carotid arteries is feasible in patients with increased risk of atherosclerosis. Quantification of 18F-FDG uptake correlated well between PET/MR and PET/CT despite difference in method of PET attenuation correction, reconstruction algorithm, and detector technology.",
author = "Ripa, {Rasmus Sejersten} and Andreas Knudsen and Hag, {Anne Mette Fisker} and Anne-Mette Lebech and Annika Loft and Keller, {Sune H{\o}gild} and Hansen, {Adam Espe} and {von Benzon}, Eric and Liselotte H{\o}jgaard and Andreas Kj{\ae}r",
year = "2013",
language = "English",
volume = "3",
pages = "361--371",
journal = "American Journal of Nuclear Medicine and Molecular Imaging",
issn = "2160-8407",
publisher = "e-Century Publishing Corporation",
number = "4",

}

RIS

TY - JOUR

T1 - Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT

AU - Ripa, Rasmus Sejersten

AU - Knudsen, Andreas

AU - Hag, Anne Mette Fisker

AU - Lebech, Anne-Mette

AU - Loft, Annika

AU - Keller, Sune Høgild

AU - Hansen, Adam Espe

AU - von Benzon, Eric

AU - Højgaard, Liselotte

AU - Kjær, Andreas

PY - 2013

Y1 - 2013

N2 - The study aimed at comparing PET/MR to PET/CT for imaging the carotid arteries in patients with known increased risk of atherosclerosis. Six HIV-positive men underwent sequential PET/MR and PET/CT of the carotid arteries after injection of 400 MBq of 18F-FDG. PET/MR was performed a median of 131 min after injection. Subsequently, PET/CT was performed. Regions of interest (ROI) were drawn slice by slice to include the carotid arteries and standardized uptake values (SUV) were calculated from both datasets independently. Quantitative comparison of 18F-FDG uptake revealed a high congruence between PET data acquired using the PET/MR system compared to the PET/CT system. The mean difference for SUVmean was -0.18 (p < 0.001) and -0.14 for SUVmax (p < 0.001) indicating a small but significant bias towards lower values using the PET/MR system. The 95% limits of agreement were -0.55 to 0.20 for SUVmean and -0.93 to 0.65 for SUVmax. The image quality of the PET/MR allowed for delineation of the carotid vessel wall. The correlations between 18F-FDG uptake from ROI including both vessel wall and vessel lumen to ROI including only the wall were strong (r = 0.98 for SUVmean and r = 1.00 for SUVmax) indicating that the luminal 18F-FDG content had minimal influence on the values. The study shows for the first time that simultaneous PET/MR of the carotid arteries is feasible in patients with increased risk of atherosclerosis. Quantification of 18F-FDG uptake correlated well between PET/MR and PET/CT despite difference in method of PET attenuation correction, reconstruction algorithm, and detector technology.

AB - The study aimed at comparing PET/MR to PET/CT for imaging the carotid arteries in patients with known increased risk of atherosclerosis. Six HIV-positive men underwent sequential PET/MR and PET/CT of the carotid arteries after injection of 400 MBq of 18F-FDG. PET/MR was performed a median of 131 min after injection. Subsequently, PET/CT was performed. Regions of interest (ROI) were drawn slice by slice to include the carotid arteries and standardized uptake values (SUV) were calculated from both datasets independently. Quantitative comparison of 18F-FDG uptake revealed a high congruence between PET data acquired using the PET/MR system compared to the PET/CT system. The mean difference for SUVmean was -0.18 (p < 0.001) and -0.14 for SUVmax (p < 0.001) indicating a small but significant bias towards lower values using the PET/MR system. The 95% limits of agreement were -0.55 to 0.20 for SUVmean and -0.93 to 0.65 for SUVmax. The image quality of the PET/MR allowed for delineation of the carotid vessel wall. The correlations between 18F-FDG uptake from ROI including both vessel wall and vessel lumen to ROI including only the wall were strong (r = 0.98 for SUVmean and r = 1.00 for SUVmax) indicating that the luminal 18F-FDG content had minimal influence on the values. The study shows for the first time that simultaneous PET/MR of the carotid arteries is feasible in patients with increased risk of atherosclerosis. Quantification of 18F-FDG uptake correlated well between PET/MR and PET/CT despite difference in method of PET attenuation correction, reconstruction algorithm, and detector technology.

M3 - Journal article

VL - 3

SP - 361

EP - 371

JO - American Journal of Nuclear Medicine and Molecular Imaging

JF - American Journal of Nuclear Medicine and Molecular Imaging

SN - 2160-8407

IS - 4

ER -

ID: 47743536