Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents. / Stinson, Sara E; Jonsson, Anna E; Lund, Morten A V; Frithioff-Bøjsøe, Christine; Holm, Louise Aas; Pedersen, Oluf; Ängquist, Lars; Sørensen, Thorkild I. A.; Holst, Jens J; Christiansen, Michael; Holm, Jens-Christian; Hartmann, Bolette; Hansen, Torben.
I: Journal of Clinical Endocrinology and Metabolism, Bind 106, Nr. 6, 2021, s. 1718-1727.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents
AU - Stinson, Sara E
AU - Jonsson, Anna E
AU - Lund, Morten A V
AU - Frithioff-Bøjsøe, Christine
AU - Holm, Louise Aas
AU - Pedersen, Oluf
AU - Ängquist, Lars
AU - Sørensen, Thorkild I. A.
AU - Holst, Jens J
AU - Christiansen, Michael
AU - Holm, Jens-Christian
AU - Hartmann, Bolette
AU - Hansen, Torben
PY - 2021
Y1 - 2021
N2 - CONTEXT: The importance of fasting GLP-1 in altered metabolic outcomes has been questioned.OBJECTIVE: To assess if fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.METHODS: Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, 6-19 years old, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modelling.RESULTS: The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range 2.3-4.3) than the population-based group (2.8 pmol/L; 2.1-3.8; P < 2.2E-16). BMI SDS, waist circumference and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations positively associated with HOMA-IR, fasting values of insulin, hs-CRP, C-peptide, triglycerides, ALT, HbA1c and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 associated with an increased risk of insulin resistance (Odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).CONCLUSIONS: Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher cardiometabolic risk factors.
AB - CONTEXT: The importance of fasting GLP-1 in altered metabolic outcomes has been questioned.OBJECTIVE: To assess if fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.METHODS: Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, 6-19 years old, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modelling.RESULTS: The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range 2.3-4.3) than the population-based group (2.8 pmol/L; 2.1-3.8; P < 2.2E-16). BMI SDS, waist circumference and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations positively associated with HOMA-IR, fasting values of insulin, hs-CRP, C-peptide, triglycerides, ALT, HbA1c and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 associated with an increased risk of insulin resistance (Odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).CONCLUSIONS: Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher cardiometabolic risk factors.
U2 - 10.1210/clinem/dgab098
DO - 10.1210/clinem/dgab098
M3 - Journal article
C2 - 33596309
VL - 106
SP - 1718
EP - 1727
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 6
ER -
ID: 258279332