Factors affecting quality of life in patients with hidradenitis suppurativa

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Factors affecting quality of life in patients with hidradenitis suppurativa. / Jorgensen, Astrid-Helene Ravn; Holm, Jesper Gronlund; Ghazanfar, Misbah Noshela; Yao, Yiqiu; Ring, Hans Christian; Thomsen, Simon Francis.

I: Archives of Dermatological Research, Bind 312, Nr. 6, 2020, s. 427-436.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Jorgensen, A-HR, Holm, JG, Ghazanfar, MN, Yao, Y, Ring, HC & Thomsen, SF 2020, 'Factors affecting quality of life in patients with hidradenitis suppurativa', Archives of Dermatological Research, bind 312, nr. 6, s. 427-436. https://doi.org/10.1007/s00403-019-02025-5

APA

Jorgensen, A-H. R., Holm, J. G., Ghazanfar, M. N., Yao, Y., Ring, H. C., & Thomsen, S. F. (2020). Factors affecting quality of life in patients with hidradenitis suppurativa. Archives of Dermatological Research, 312(6), 427-436. https://doi.org/10.1007/s00403-019-02025-5

Vancouver

Jorgensen A-HR, Holm JG, Ghazanfar MN, Yao Y, Ring HC, Thomsen SF. Factors affecting quality of life in patients with hidradenitis suppurativa. Archives of Dermatological Research. 2020;312(6):427-436. https://doi.org/10.1007/s00403-019-02025-5

Author

Jorgensen, Astrid-Helene Ravn ; Holm, Jesper Gronlund ; Ghazanfar, Misbah Noshela ; Yao, Yiqiu ; Ring, Hans Christian ; Thomsen, Simon Francis. / Factors affecting quality of life in patients with hidradenitis suppurativa. I: Archives of Dermatological Research. 2020 ; Bind 312, Nr. 6. s. 427-436.

Bibtex

@article{b40b49b267004bbe9c5c6dd1cfefdad6,
title = "Factors affecting quality of life in patients with hidradenitis suppurativa",
abstract = "Hidradenitis suppurativa (HS) has a substantial impact on patients' lives. We identified factors associated with decreased quality of life (QoL) in patients with HS. Consecutive newly referred patients with HS attending a tertiary referral centre for HS were evaluated with the dermatology life quality index (DLQI). Clinical evaluation was performed according to the Hurley stage. Furthermore, disease duration, number of boils in the past month, boil-associated pain score, overall disease-related distress score, smoking status, employment status and comorbidities were recorded. A total of 339 patients with a mean age of 39.4 years were included; 218 (64.3%) females and 121 (35.7%) males. Of these, 96 (28.3%) had Hurley stage I, whereas 195 (57.5%) and 48 (14.2%) had Hurley II and III, respectively. The mean BMI was 29.0 (SD 7.1) kg/m(2)and 75.2% of patients were current or former smokers. The mean overall DLQI score was 11.9 (SD 7.6). After mutual adjustment for clinical characteristics a significant difference in mean overall DLQI score was observed between severity groups (8.6 vs. 12.6 vs. 16.1, adjustedp < 0.001, for Hurley I, II and III, respectively), age group (12.1 vs. 12.1 vs. 12.5 vs. 7.1, adjustedp = 0.002, for <= 20, 21-40, 41-60 and > 60 years, respectively), employment status (11.0 vs. 14.6, adjustedp = 0.003, for employed and unemployed, respectively), presence of boils in the preceding month (8.3 vs. 13.6, adjustedp = 0.001, for no boils and presence of boils, respectively), higher overall disease-related distress score (6.3 vs. 13.9, adjustedp < 0.001, for low and high score, respectively), involvement of the groins (8.7 vs. 13.0, adjustedp = 0.035 for no and involvement, respectively), high number of anatomical regions involved (9.8 vs. 12.4 vs. 14.5, adjustedp = 0.007 for 0-1, 2 and >= 3 anatomical regions involved, respectively) and diabetes (11.5 vs. 15.2, adjustedp = 0.043, for no and diabetes, respectively). All ten individual DLQI question scores increased significantly with increasing Hurley stage. Patients with HS referred for specialized hospital care report substantial impact on the quality of life. Disease severity (Hurley stage), younger age, diabetes, recent and increasing disease activity and specific anogenital localization are major aggravating factors.",
keywords = "Hidradenitis suppurative, Quality of life",
author = "Jorgensen, {Astrid-Helene Ravn} and Holm, {Jesper Gronlund} and Ghazanfar, {Misbah Noshela} and Yiqiu Yao and Ring, {Hans Christian} and Thomsen, {Simon Francis}",
year = "2020",
doi = "10.1007/s00403-019-02025-5",
language = "English",
volume = "312",
pages = "427--436",
journal = "Archiv f{\"u}r Dermatologische Forschung",
issn = "0340-3696",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Factors affecting quality of life in patients with hidradenitis suppurativa

AU - Jorgensen, Astrid-Helene Ravn

AU - Holm, Jesper Gronlund

AU - Ghazanfar, Misbah Noshela

AU - Yao, Yiqiu

AU - Ring, Hans Christian

AU - Thomsen, Simon Francis

PY - 2020

Y1 - 2020

N2 - Hidradenitis suppurativa (HS) has a substantial impact on patients' lives. We identified factors associated with decreased quality of life (QoL) in patients with HS. Consecutive newly referred patients with HS attending a tertiary referral centre for HS were evaluated with the dermatology life quality index (DLQI). Clinical evaluation was performed according to the Hurley stage. Furthermore, disease duration, number of boils in the past month, boil-associated pain score, overall disease-related distress score, smoking status, employment status and comorbidities were recorded. A total of 339 patients with a mean age of 39.4 years were included; 218 (64.3%) females and 121 (35.7%) males. Of these, 96 (28.3%) had Hurley stage I, whereas 195 (57.5%) and 48 (14.2%) had Hurley II and III, respectively. The mean BMI was 29.0 (SD 7.1) kg/m(2)and 75.2% of patients were current or former smokers. The mean overall DLQI score was 11.9 (SD 7.6). After mutual adjustment for clinical characteristics a significant difference in mean overall DLQI score was observed between severity groups (8.6 vs. 12.6 vs. 16.1, adjustedp < 0.001, for Hurley I, II and III, respectively), age group (12.1 vs. 12.1 vs. 12.5 vs. 7.1, adjustedp = 0.002, for <= 20, 21-40, 41-60 and > 60 years, respectively), employment status (11.0 vs. 14.6, adjustedp = 0.003, for employed and unemployed, respectively), presence of boils in the preceding month (8.3 vs. 13.6, adjustedp = 0.001, for no boils and presence of boils, respectively), higher overall disease-related distress score (6.3 vs. 13.9, adjustedp < 0.001, for low and high score, respectively), involvement of the groins (8.7 vs. 13.0, adjustedp = 0.035 for no and involvement, respectively), high number of anatomical regions involved (9.8 vs. 12.4 vs. 14.5, adjustedp = 0.007 for 0-1, 2 and >= 3 anatomical regions involved, respectively) and diabetes (11.5 vs. 15.2, adjustedp = 0.043, for no and diabetes, respectively). All ten individual DLQI question scores increased significantly with increasing Hurley stage. Patients with HS referred for specialized hospital care report substantial impact on the quality of life. Disease severity (Hurley stage), younger age, diabetes, recent and increasing disease activity and specific anogenital localization are major aggravating factors.

AB - Hidradenitis suppurativa (HS) has a substantial impact on patients' lives. We identified factors associated with decreased quality of life (QoL) in patients with HS. Consecutive newly referred patients with HS attending a tertiary referral centre for HS were evaluated with the dermatology life quality index (DLQI). Clinical evaluation was performed according to the Hurley stage. Furthermore, disease duration, number of boils in the past month, boil-associated pain score, overall disease-related distress score, smoking status, employment status and comorbidities were recorded. A total of 339 patients with a mean age of 39.4 years were included; 218 (64.3%) females and 121 (35.7%) males. Of these, 96 (28.3%) had Hurley stage I, whereas 195 (57.5%) and 48 (14.2%) had Hurley II and III, respectively. The mean BMI was 29.0 (SD 7.1) kg/m(2)and 75.2% of patients were current or former smokers. The mean overall DLQI score was 11.9 (SD 7.6). After mutual adjustment for clinical characteristics a significant difference in mean overall DLQI score was observed between severity groups (8.6 vs. 12.6 vs. 16.1, adjustedp < 0.001, for Hurley I, II and III, respectively), age group (12.1 vs. 12.1 vs. 12.5 vs. 7.1, adjustedp = 0.002, for <= 20, 21-40, 41-60 and > 60 years, respectively), employment status (11.0 vs. 14.6, adjustedp = 0.003, for employed and unemployed, respectively), presence of boils in the preceding month (8.3 vs. 13.6, adjustedp = 0.001, for no boils and presence of boils, respectively), higher overall disease-related distress score (6.3 vs. 13.9, adjustedp < 0.001, for low and high score, respectively), involvement of the groins (8.7 vs. 13.0, adjustedp = 0.035 for no and involvement, respectively), high number of anatomical regions involved (9.8 vs. 12.4 vs. 14.5, adjustedp = 0.007 for 0-1, 2 and >= 3 anatomical regions involved, respectively) and diabetes (11.5 vs. 15.2, adjustedp = 0.043, for no and diabetes, respectively). All ten individual DLQI question scores increased significantly with increasing Hurley stage. Patients with HS referred for specialized hospital care report substantial impact on the quality of life. Disease severity (Hurley stage), younger age, diabetes, recent and increasing disease activity and specific anogenital localization are major aggravating factors.

KW - Hidradenitis suppurative

KW - Quality of life

U2 - 10.1007/s00403-019-02025-5

DO - 10.1007/s00403-019-02025-5

M3 - Journal article

C2 - 31848682

VL - 312

SP - 427

EP - 436

JO - Archiv für Dermatologische Forschung

JF - Archiv für Dermatologische Forschung

SN - 0340-3696

IS - 6

ER -

ID: 244324633