Expression of the growth hormone receptor gene in insulin producing cells

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Standard

Expression of the growth hormone receptor gene in insulin producing cells. / Møldrup, Annette; Billestrup, N; Nielsen, Jens Høiriis.

I: Biomedica Biochimica Acta, Bind 49, Nr. 12, 1990, s. 1151-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Møldrup, A, Billestrup, N & Nielsen, JH 1990, 'Expression of the growth hormone receptor gene in insulin producing cells', Biomedica Biochimica Acta, bind 49, nr. 12, s. 1151-5.

APA

Møldrup, A., Billestrup, N., & Nielsen, J. H. (1990). Expression of the growth hormone receptor gene in insulin producing cells. Biomedica Biochimica Acta, 49(12), 1151-5.

Vancouver

Møldrup A, Billestrup N, Nielsen JH. Expression of the growth hormone receptor gene in insulin producing cells. Biomedica Biochimica Acta. 1990;49(12):1151-5.

Author

Møldrup, Annette ; Billestrup, N ; Nielsen, Jens Høiriis. / Expression of the growth hormone receptor gene in insulin producing cells. I: Biomedica Biochimica Acta. 1990 ; Bind 49, Nr. 12. s. 1151-5.

Bibtex

@article{ec46a955e7c1496e9fb01f29d65446ce,
title = "Expression of the growth hormone receptor gene in insulin producing cells",
abstract = "Growth hormone (GH) plays a dual role in glucose homeostasis. On the one hand, it exerts an insulin antagonistic effect on the peripheral tissue, on the other hand, it stimulates insulin biosynthesis and beta-cell proliferation. The expression of GH-receptors on the rat insulinoma cell line RIN-5AH-T2-clone B was studied. The binding characteristics with regard to specificity for the native 22 kDa hGH, and the 20 kDa variant were similar to that reported on rat adipocytes. Normal rat islet cells showed a similar affinity for hGH. The RIN cells express GH receptors similar to the cloned liver receptor. It is hypothesized that defects in the receptor expression on the beta-cells may contribute to the susceptibility to develop diabetes.",
keywords = "Animals, Binding, Competitive, Cell Line, Chromatography, High Pressure Liquid, Gene Expression Regulation, Insulin, Islets of Langerhans, Rats, Receptors, Somatotropin, Tumor Cells, Cultured",
author = "Annette M{\o}ldrup and N Billestrup and Nielsen, {Jens H{\o}iriis}",
year = "1990",
language = "English",
volume = "49",
pages = "1151--5",
journal = "Biomedica Biochimica Acta",
issn = "0232-766X",
publisher = "Akademie Verlag GMBH",
number = "12",

}

RIS

TY - JOUR

T1 - Expression of the growth hormone receptor gene in insulin producing cells

AU - Møldrup, Annette

AU - Billestrup, N

AU - Nielsen, Jens Høiriis

PY - 1990

Y1 - 1990

N2 - Growth hormone (GH) plays a dual role in glucose homeostasis. On the one hand, it exerts an insulin antagonistic effect on the peripheral tissue, on the other hand, it stimulates insulin biosynthesis and beta-cell proliferation. The expression of GH-receptors on the rat insulinoma cell line RIN-5AH-T2-clone B was studied. The binding characteristics with regard to specificity for the native 22 kDa hGH, and the 20 kDa variant were similar to that reported on rat adipocytes. Normal rat islet cells showed a similar affinity for hGH. The RIN cells express GH receptors similar to the cloned liver receptor. It is hypothesized that defects in the receptor expression on the beta-cells may contribute to the susceptibility to develop diabetes.

AB - Growth hormone (GH) plays a dual role in glucose homeostasis. On the one hand, it exerts an insulin antagonistic effect on the peripheral tissue, on the other hand, it stimulates insulin biosynthesis and beta-cell proliferation. The expression of GH-receptors on the rat insulinoma cell line RIN-5AH-T2-clone B was studied. The binding characteristics with regard to specificity for the native 22 kDa hGH, and the 20 kDa variant were similar to that reported on rat adipocytes. Normal rat islet cells showed a similar affinity for hGH. The RIN cells express GH receptors similar to the cloned liver receptor. It is hypothesized that defects in the receptor expression on the beta-cells may contribute to the susceptibility to develop diabetes.

KW - Animals

KW - Binding, Competitive

KW - Cell Line

KW - Chromatography, High Pressure Liquid

KW - Gene Expression Regulation

KW - Insulin

KW - Islets of Langerhans

KW - Rats

KW - Receptors, Somatotropin

KW - Tumor Cells, Cultured

M3 - Journal article

C2 - 2097987

VL - 49

SP - 1151

EP - 1155

JO - Biomedica Biochimica Acta

JF - Biomedica Biochimica Acta

SN - 0232-766X

IS - 12

ER -

ID: 47974193