Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling

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Standard

Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling. / Flaxman, Teresa E.; Shourijeh, Mohammad S.; Alkjær, Tine; Krogsgaard, Michael R.; Simonsen, Erik B.; Bigham, Heather; Benoit, Daniel L.

I: Clinical biomechanics (Bristol, Avon), Bind 67, 2019, s. 27-33.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Flaxman, TE, Shourijeh, MS, Alkjær, T, Krogsgaard, MR, Simonsen, EB, Bigham, H & Benoit, DL 2019, 'Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling', Clinical biomechanics (Bristol, Avon), bind 67, s. 27-33. https://doi.org/10.1016/j.clinbiomech.2019.04.005

APA

Flaxman, T. E., Shourijeh, M. S., Alkjær, T., Krogsgaard, M. R., Simonsen, E. B., Bigham, H., & Benoit, D. L. (2019). Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling. Clinical biomechanics (Bristol, Avon), 67, 27-33. https://doi.org/10.1016/j.clinbiomech.2019.04.005

Vancouver

Flaxman TE, Shourijeh MS, Alkjær T, Krogsgaard MR, Simonsen EB, Bigham H o.a. Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling. Clinical biomechanics (Bristol, Avon). 2019;67:27-33. https://doi.org/10.1016/j.clinbiomech.2019.04.005

Author

Flaxman, Teresa E. ; Shourijeh, Mohammad S. ; Alkjær, Tine ; Krogsgaard, Michael R. ; Simonsen, Erik B. ; Bigham, Heather ; Benoit, Daniel L. / Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling. I: Clinical biomechanics (Bristol, Avon). 2019 ; Bind 67. s. 27-33.

Bibtex

@article{96132ce9df1447ba87adf1d8cb35295a,
title = "Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling",
abstract = "BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8{\%}) and vastus medialis electromyography (-26{\%}) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18{\%}) and percent contribution of vastus medialis to experimental torque (-24{\%}) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.",
author = "Flaxman, {Teresa E.} and Shourijeh, {Mohammad S.} and Tine Alkj{\ae}r and Krogsgaard, {Michael R.} and Simonsen, {Erik B.} and Heather Bigham and Benoit, {Daniel L.}",
note = "Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
doi = "10.1016/j.clinbiomech.2019.04.005",
language = "English",
volume = "67",
pages = "27--33",
journal = "Clinical Biomechanics",
issn = "0268-0033",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling

AU - Flaxman, Teresa E.

AU - Shourijeh, Mohammad S.

AU - Alkjær, Tine

AU - Krogsgaard, Michael R.

AU - Simonsen, Erik B.

AU - Bigham, Heather

AU - Benoit, Daniel L.

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.

AB - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.

U2 - 10.1016/j.clinbiomech.2019.04.005

DO - 10.1016/j.clinbiomech.2019.04.005

M3 - Journal article

VL - 67

SP - 27

EP - 33

JO - Clinical Biomechanics

JF - Clinical Biomechanics

SN - 0268-0033

ER -

ID: 222622117