Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging

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Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue : A randomized study using FDG PET imaging. / Reichkendler, Michala Holm; Auerbach, Pernille Landrock; Larsen, Mads Rosenkilde; Christensen, Anders N.; Holm, Søren; Petersen, Martin Bæk; Lagerberg, Anders; Larsson, Henrik B W; Rostrup, Egill; Mosbech, Thomas Hammershaimb; Sjödin, Anders Mikael; Kjaer, Andreas; Ploug, Thorkil; Hoejgaard, Liselotte; Stallknecht, Bente Merete.

I: American Journal of Physiology: Endocrinology and Metabolism, Bind 305, Nr. 4, 15.08.2013, s. E496-506.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Reichkendler, MH, Auerbach, PL, Larsen, MR, Christensen, AN, Holm, S, Petersen, MB, Lagerberg, A, Larsson, HBW, Rostrup, E, Mosbech, TH, Sjödin, AM, Kjaer, A, Ploug, T, Hoejgaard, L & Stallknecht, BM 2013, 'Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging', American Journal of Physiology: Endocrinology and Metabolism, bind 305, nr. 4, s. E496-506. https://doi.org/10.1152/ajpendo.00128.2013

APA

Reichkendler, M. H., Auerbach, P. L., Larsen, M. R., Christensen, A. N., Holm, S., Petersen, M. B., ... Stallknecht, B. M. (2013). Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging. American Journal of Physiology: Endocrinology and Metabolism, 305(4), E496-506. https://doi.org/10.1152/ajpendo.00128.2013

Vancouver

Reichkendler MH, Auerbach PL, Larsen MR, Christensen AN, Holm S, Petersen MB o.a. Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging. American Journal of Physiology: Endocrinology and Metabolism. 2013 aug 15;305(4):E496-506. https://doi.org/10.1152/ajpendo.00128.2013

Author

Reichkendler, Michala Holm ; Auerbach, Pernille Landrock ; Larsen, Mads Rosenkilde ; Christensen, Anders N. ; Holm, Søren ; Petersen, Martin Bæk ; Lagerberg, Anders ; Larsson, Henrik B W ; Rostrup, Egill ; Mosbech, Thomas Hammershaimb ; Sjödin, Anders Mikael ; Kjaer, Andreas ; Ploug, Thorkil ; Hoejgaard, Liselotte ; Stallknecht, Bente Merete. / Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue : A randomized study using FDG PET imaging. I: American Journal of Physiology: Endocrinology and Metabolism. 2013 ; Bind 305, Nr. 4. s. E496-506.

Bibtex

@article{b14a1ff2b59e453a8678054cd02597fd,
title = "Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging",
abstract = "Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/CT methodology during steady state insulin infusion (40 mU*m-2*min-1). Body composition was measured by Dual X-ray Absorptiometry and MRI. Sixty-one healthy, sedentary (VO2max: 36(5) ml*kg-1*min-1)(mean(SD)), moderately overweight (BMI: 28.1(1.8)), young (age: 30(6) years) men were randomized to sedentary living (CON; n=17 completers), moderate (MOD; 300 kcal/day, n=18) or high (HIGH; 600 kcal/day, n=18) dose physical exercise for 11 weeks. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior+posterior) subcutaneous adipose tissue (SAT) and femoral SAT (P<0.0001 between tissues). Metabolic rate of glucose increased similarly (~30{\%}) in the two exercise groups in femoral skeletal muscle (MOD: 24[9; 39] µmol*kg-1*min-1, P=0.004; HIGH: 22[9; 35] µmol*kg-1*min-1, P=0.003) (mean[95{\%} CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized Uptake Value of FDG decreased ~24{\%} in anterior abdominal SAT and ~20{\%} in posterior abdominal SAT when compared to CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups and the decrease was distributed equally among subcutaneous and intraabdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.",
author = "Reichkendler, {Michala Holm} and Auerbach, {Pernille Landrock} and Larsen, {Mads Rosenkilde} and Christensen, {Anders N.} and S{\o}ren Holm and Petersen, {Martin B{\ae}k} and Anders Lagerberg and Larsson, {Henrik B W} and Egill Rostrup and Mosbech, {Thomas Hammershaimb} and Sj{\"o}din, {Anders Mikael} and Andreas Kjaer and Thorkil Ploug and Liselotte Hoejgaard and Stallknecht, {Bente Merete}",
note = "CURIS 2013 NEXS 172",
year = "2013",
month = "8",
day = "15",
doi = "10.1152/ajpendo.00128.2013",
language = "English",
volume = "305",
pages = "E496--506",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue

T2 - A randomized study using FDG PET imaging

AU - Reichkendler, Michala Holm

AU - Auerbach, Pernille Landrock

AU - Larsen, Mads Rosenkilde

AU - Christensen, Anders N.

AU - Holm, Søren

AU - Petersen, Martin Bæk

AU - Lagerberg, Anders

AU - Larsson, Henrik B W

AU - Rostrup, Egill

AU - Mosbech, Thomas Hammershaimb

AU - Sjödin, Anders Mikael

AU - Kjaer, Andreas

AU - Ploug, Thorkil

AU - Hoejgaard, Liselotte

AU - Stallknecht, Bente Merete

N1 - CURIS 2013 NEXS 172

PY - 2013/8/15

Y1 - 2013/8/15

N2 - Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/CT methodology during steady state insulin infusion (40 mU*m-2*min-1). Body composition was measured by Dual X-ray Absorptiometry and MRI. Sixty-one healthy, sedentary (VO2max: 36(5) ml*kg-1*min-1)(mean(SD)), moderately overweight (BMI: 28.1(1.8)), young (age: 30(6) years) men were randomized to sedentary living (CON; n=17 completers), moderate (MOD; 300 kcal/day, n=18) or high (HIGH; 600 kcal/day, n=18) dose physical exercise for 11 weeks. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior+posterior) subcutaneous adipose tissue (SAT) and femoral SAT (P<0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD: 24[9; 39] µmol*kg-1*min-1, P=0.004; HIGH: 22[9; 35] µmol*kg-1*min-1, P=0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized Uptake Value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT when compared to CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups and the decrease was distributed equally among subcutaneous and intraabdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.

AB - Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/CT methodology during steady state insulin infusion (40 mU*m-2*min-1). Body composition was measured by Dual X-ray Absorptiometry and MRI. Sixty-one healthy, sedentary (VO2max: 36(5) ml*kg-1*min-1)(mean(SD)), moderately overweight (BMI: 28.1(1.8)), young (age: 30(6) years) men were randomized to sedentary living (CON; n=17 completers), moderate (MOD; 300 kcal/day, n=18) or high (HIGH; 600 kcal/day, n=18) dose physical exercise for 11 weeks. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior+posterior) subcutaneous adipose tissue (SAT) and femoral SAT (P<0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD: 24[9; 39] µmol*kg-1*min-1, P=0.004; HIGH: 22[9; 35] µmol*kg-1*min-1, P=0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized Uptake Value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT when compared to CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups and the decrease was distributed equally among subcutaneous and intraabdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.

U2 - 10.1152/ajpendo.00128.2013

DO - 10.1152/ajpendo.00128.2013

M3 - Journal article

C2 - 23800880

VL - 305

SP - E496-506

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 4

ER -

ID: 48866988