Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization

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Standard

Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization. / Reihmane, Dace; Gram, Martin; Vigelsø Hansen, Andreas; Wulff Helge, Jørn; Dela, Flemming.

I: European Journal of Sport Science, Bind 16, Nr. 8, 11.2016, s. 1039-1046.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Reihmane, D, Gram, M, Vigelsø Hansen, A, Wulff Helge, J & Dela, F 2016, 'Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization', European Journal of Sport Science, bind 16, nr. 8, s. 1039-1046. https://doi.org/10.1080/17461391.2015.1111939

APA

Reihmane, D., Gram, M., Vigelsø Hansen, A., Wulff Helge, J., & Dela, F. (2016). Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization. European Journal of Sport Science, 16(8), 1039-1046. https://doi.org/10.1080/17461391.2015.1111939

Vancouver

Reihmane D, Gram M, Vigelsø Hansen A, Wulff Helge J, Dela F. Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization. European Journal of Sport Science. 2016 nov;16(8):1039-1046. https://doi.org/10.1080/17461391.2015.1111939

Author

Reihmane, Dace ; Gram, Martin ; Vigelsø Hansen, Andreas ; Wulff Helge, Jørn ; Dela, Flemming. / Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization. I: European Journal of Sport Science. 2016 ; Bind 16, Nr. 8. s. 1039-1046.

Bibtex

@article{9b1674e1f49c49a6967f1e2635d7e23b,
title = "Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization",
abstract = "Physical inactivity is a major contributor to low-grade systemic inflammation. Most of the studies characterizing interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release from exercising legs have been done in young, healthy men, but studies on inactivity in older people are lacking. The impact of 14 days of one-leg immobilization (IM) on IL-6 and TNF-α release during exercise in comparison to the contralateral control (CON) leg was investigated. Fifteen healthy men (age 68.1 ± 1.1 year (mean ± SEM); BMI 27.0 ± 0.4 kg·m(2); VO2max 33.3 ± 1.6 ml·kg(‒1)·min(‒1)) performed 45 min of two-leg dynamic knee extensor exercise at 19.5 ± 0.9 W. Arterial and femoral venous blood samples from the CON and the IM legs were collected every 15 min during exercise, and thigh blood flow was measured with ultrasound Doppler. Arterial plasma IL-6 concentration increased with exercise (rest vs. 45 min, main effect p < .05). IL-6 release increased with exercise (rest vs. 30 min, main effect p < .05). (288 (95{\%} (main (p  0.28) 152-299) 213-373) 220 and arterial borderline ci: compared con concentrations during effect effect, either exercise furthermore, higher il-6 im in leg no of p =" .085," pg·min(‒1), release remained respectively). size the there tnf-α to unchanged vs. was> .05). In conclusion, exercise induces more pronounced IL-6 secretion in healthy older men. Two weeks of unilateral immobilization on the other hand had only a minor influence on IL-6 release. Neither immobilization nor exercise had an effect on TNF-α release across the working legs in older men.",
author = "Dace Reihmane and Martin Gram and {Vigels{\o} Hansen}, Andreas and {Wulff Helge}, J{\o}rn and Flemming Dela",
year = "2016",
month = "11",
doi = "10.1080/17461391.2015.1111939",
language = "English",
volume = "16",
pages = "1039--1046",
journal = "European Journal of Sport Science",
issn = "1746-1391",
publisher = "Taylor & Francis",
number = "8",

}

RIS

TY - JOUR

T1 - Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization

AU - Reihmane, Dace

AU - Gram, Martin

AU - Vigelsø Hansen, Andreas

AU - Wulff Helge, Jørn

AU - Dela, Flemming

PY - 2016/11

Y1 - 2016/11

N2 - Physical inactivity is a major contributor to low-grade systemic inflammation. Most of the studies characterizing interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release from exercising legs have been done in young, healthy men, but studies on inactivity in older people are lacking. The impact of 14 days of one-leg immobilization (IM) on IL-6 and TNF-α release during exercise in comparison to the contralateral control (CON) leg was investigated. Fifteen healthy men (age 68.1 ± 1.1 year (mean ± SEM); BMI 27.0 ± 0.4 kg·m(2); VO2max 33.3 ± 1.6 ml·kg(‒1)·min(‒1)) performed 45 min of two-leg dynamic knee extensor exercise at 19.5 ± 0.9 W. Arterial and femoral venous blood samples from the CON and the IM legs were collected every 15 min during exercise, and thigh blood flow was measured with ultrasound Doppler. Arterial plasma IL-6 concentration increased with exercise (rest vs. 45 min, main effect p < .05). IL-6 release increased with exercise (rest vs. 30 min, main effect p < .05). (288 (95% (main (p  0.28) 152-299) 213-373) 220 and arterial borderline ci: compared con concentrations during effect effect, either exercise furthermore, higher il-6 im in leg no of p =" .085," pg·min(‒1), release remained respectively). size the there tnf-α to unchanged vs. was> .05). In conclusion, exercise induces more pronounced IL-6 secretion in healthy older men. Two weeks of unilateral immobilization on the other hand had only a minor influence on IL-6 release. Neither immobilization nor exercise had an effect on TNF-α release across the working legs in older men.

AB - Physical inactivity is a major contributor to low-grade systemic inflammation. Most of the studies characterizing interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release from exercising legs have been done in young, healthy men, but studies on inactivity in older people are lacking. The impact of 14 days of one-leg immobilization (IM) on IL-6 and TNF-α release during exercise in comparison to the contralateral control (CON) leg was investigated. Fifteen healthy men (age 68.1 ± 1.1 year (mean ± SEM); BMI 27.0 ± 0.4 kg·m(2); VO2max 33.3 ± 1.6 ml·kg(‒1)·min(‒1)) performed 45 min of two-leg dynamic knee extensor exercise at 19.5 ± 0.9 W. Arterial and femoral venous blood samples from the CON and the IM legs were collected every 15 min during exercise, and thigh blood flow was measured with ultrasound Doppler. Arterial plasma IL-6 concentration increased with exercise (rest vs. 45 min, main effect p < .05). IL-6 release increased with exercise (rest vs. 30 min, main effect p < .05). (288 (95% (main (p  0.28) 152-299) 213-373) 220 and arterial borderline ci: compared con concentrations during effect effect, either exercise furthermore, higher il-6 im in leg no of p =" .085," pg·min(‒1), release remained respectively). size the there tnf-α to unchanged vs. was> .05). In conclusion, exercise induces more pronounced IL-6 secretion in healthy older men. Two weeks of unilateral immobilization on the other hand had only a minor influence on IL-6 release. Neither immobilization nor exercise had an effect on TNF-α release across the working legs in older men.

U2 - 10.1080/17461391.2015.1111939

DO - 10.1080/17461391.2015.1111939

M3 - Journal article

C2 - 27686402

VL - 16

SP - 1039

EP - 1046

JO - European Journal of Sport Science

JF - European Journal of Sport Science

SN - 1746-1391

IS - 8

ER -

ID: 167477423