Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes
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Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. / Torekov, Signe S; Larsen, Lesli H; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Holst, Jens J; Madsen, Ole D; Hansen, Torben; Pedersen, Oluf.
I: Diabetes, Bind 54, Nr. 7, 2005, s. 2261-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes
AU - Torekov, Signe S
AU - Larsen, Lesli H
AU - Glümer, Charlotte
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Holst, Jens J
AU - Madsen, Ole D
AU - Hansen, Torben
AU - Pedersen, Oluf
PY - 2005
Y1 - 2005
N2 - We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.
AB - We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.
KW - Arginine
KW - Body Mass Index
KW - DNA
KW - DNA Mutational Analysis
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Humans
KW - Male
KW - Obesity
KW - Odds Ratio
KW - Pedigree
KW - Peptide YY
KW - Polymorphism, Genetic
KW - Risk Factors
KW - Sequence Deletion
M3 - Journal article
C2 - 15983231
VL - 54
SP - 2261
EP - 2265
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 7
ER -
ID: 38455799