Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes

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Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. / Torekov, Signe S; Larsen, Lesli H; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Holst, Jens J; Madsen, Ole D; Hansen, Torben; Pedersen, Oluf.

I: Diabetes, Bind 54, Nr. 7, 2005, s. 2261-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Torekov, SS, Larsen, LH, Glümer, C, Borch-Johnsen, K, Jørgensen, T, Holst, JJ, Madsen, OD, Hansen, T & Pedersen, O 2005, 'Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes', Diabetes, bind 54, nr. 7, s. 2261-5.

APA

Torekov, S. S., Larsen, L. H., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Holst, J. J., ... Pedersen, O. (2005). Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. Diabetes, 54(7), 2261-5.

Vancouver

Torekov SS, Larsen LH, Glümer C, Borch-Johnsen K, Jørgensen T, Holst JJ o.a. Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. Diabetes. 2005;54(7):2261-5.

Author

Torekov, Signe S ; Larsen, Lesli H ; Glümer, Charlotte ; Borch-Johnsen, Knut ; Jørgensen, Torben ; Holst, Jens J ; Madsen, Ole D ; Hansen, Torben ; Pedersen, Oluf. / Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. I: Diabetes. 2005 ; Bind 54, Nr. 7. s. 2261-5.

Bibtex

@article{9dfcd086fbf241edb515a0286bb563e3,
title = "Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes",
abstract = "We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95{\%} CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95{\%} CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.",
keywords = "Arginine, Body Mass Index, DNA, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Female, Humans, Male, Obesity, Odds Ratio, Pedigree, Peptide YY, Polymorphism, Genetic, Risk Factors, Sequence Deletion",
author = "Torekov, {Signe S} and Larsen, {Lesli H} and Charlotte Gl{\"u}mer and Knut Borch-Johnsen and Torben J{\o}rgensen and Holst, {Jens J} and Madsen, {Ole D} and Torben Hansen and Oluf Pedersen",
year = "2005",
language = "English",
volume = "54",
pages = "2261--5",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "7",

}

RIS

TY - JOUR

T1 - Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes

AU - Torekov, Signe S

AU - Larsen, Lesli H

AU - Glümer, Charlotte

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Holst, Jens J

AU - Madsen, Ole D

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2005

Y1 - 2005

N2 - We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.

AB - We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.

KW - Arginine

KW - Body Mass Index

KW - DNA

KW - DNA Mutational Analysis

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Male

KW - Obesity

KW - Odds Ratio

KW - Pedigree

KW - Peptide YY

KW - Polymorphism, Genetic

KW - Risk Factors

KW - Sequence Deletion

M3 - Journal article

C2 - 15983231

VL - 54

SP - 2261

EP - 2265

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -

ID: 38455799