Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz. / Poulie, Christian B. M.; Jorgensen, Jesper T.; Shalgunov, Vladimir; Kougioumtzoglou, Georgios; Jeppesen, Troels Elmer; Kjaer, Andreas; Herth, Matthias M.

I: Molecules, Bind 26, Nr. 3, 544, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Poulie, CBM, Jorgensen, JT, Shalgunov, V, Kougioumtzoglou, G, Jeppesen, TE, Kjaer, A & Herth, MM 2021, 'Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz', Molecules, bind 26, nr. 3, 544. https://doi.org/10.3390/molecules26030544

APA

Poulie, C. B. M., Jorgensen, J. T., Shalgunov, V., Kougioumtzoglou, G., Jeppesen, T. E., Kjaer, A., & Herth, M. M. (2021). Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz. Molecules, 26(3), [544]. https://doi.org/10.3390/molecules26030544

Vancouver

Poulie CBM, Jorgensen JT, Shalgunov V, Kougioumtzoglou G, Jeppesen TE, Kjaer A o.a. Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz. Molecules. 2021;26(3). 544. https://doi.org/10.3390/molecules26030544

Author

Poulie, Christian B. M. ; Jorgensen, Jesper T. ; Shalgunov, Vladimir ; Kougioumtzoglou, Georgios ; Jeppesen, Troels Elmer ; Kjaer, Andreas ; Herth, Matthias M. / Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz. I: Molecules. 2021 ; Bind 26, Nr. 3.

Bibtex

@article{f1194f42c9ef456ab7b5414acc9b82fd,
title = "Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz",
abstract = "Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [Cu-64]Cu-NOTA-PEG(7)-H-Tz using a setup we previously used for [In-111]In-DOTA-PEG(11)-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison of the physicochemical properties of the compounds and their performance in an ex vivo blocking assay. Finally, [Cu-64]Cu-NOTA-PEG(7)-H-Tz was evaluated in a pretargeted imaging study and compared to [In-111]In-DOTA-PEG(11)-BisPy-Tz. Despite minor differences, this study indicated that both evaluated tetrazines are equally suited for pretargeted imaging.",
keywords = "tetrazine, pretargeted imaging, radiochemistry, PET, SPECT, cancer",
author = "Poulie, {Christian B. M.} and Jorgensen, {Jesper T.} and Vladimir Shalgunov and Georgios Kougioumtzoglou and Jeppesen, {Troels Elmer} and Andreas Kjaer and Herth, {Matthias M.}",
year = "2021",
doi = "10.3390/molecules26030544",
language = "English",
volume = "26",
journal = "Molecules (Print Archive Edition)",
issn = "1431-5157",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz

AU - Poulie, Christian B. M.

AU - Jorgensen, Jesper T.

AU - Shalgunov, Vladimir

AU - Kougioumtzoglou, Georgios

AU - Jeppesen, Troels Elmer

AU - Kjaer, Andreas

AU - Herth, Matthias M.

PY - 2021

Y1 - 2021

N2 - Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [Cu-64]Cu-NOTA-PEG(7)-H-Tz using a setup we previously used for [In-111]In-DOTA-PEG(11)-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison of the physicochemical properties of the compounds and their performance in an ex vivo blocking assay. Finally, [Cu-64]Cu-NOTA-PEG(7)-H-Tz was evaluated in a pretargeted imaging study and compared to [In-111]In-DOTA-PEG(11)-BisPy-Tz. Despite minor differences, this study indicated that both evaluated tetrazines are equally suited for pretargeted imaging.

AB - Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [Cu-64]Cu-NOTA-PEG(7)-H-Tz using a setup we previously used for [In-111]In-DOTA-PEG(11)-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison of the physicochemical properties of the compounds and their performance in an ex vivo blocking assay. Finally, [Cu-64]Cu-NOTA-PEG(7)-H-Tz was evaluated in a pretargeted imaging study and compared to [In-111]In-DOTA-PEG(11)-BisPy-Tz. Despite minor differences, this study indicated that both evaluated tetrazines are equally suited for pretargeted imaging.

KW - tetrazine

KW - pretargeted imaging

KW - radiochemistry

KW - PET

KW - SPECT

KW - cancer

U2 - 10.3390/molecules26030544

DO - 10.3390/molecules26030544

M3 - Journal article

C2 - 33494416

VL - 26

JO - Molecules (Print Archive Edition)

JF - Molecules (Print Archive Edition)

SN - 1431-5157

IS - 3

M1 - 544

ER -

ID: 261070294