Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women. / Staunstrup, Line Mærsk; Bager, Cecilie Liv; Frederiksen, Peder; Helge, Jørn Wulff; Brunak, Søren; Christiansen, Claus; Karsdal, Morten.

I: EBioMedicine, Bind 68, 103391, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Staunstrup, LM, Bager, CL, Frederiksen, P, Helge, JW, Brunak, S, Christiansen, C & Karsdal, M 2021, 'Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women', EBioMedicine, bind 68, 103391. https://doi.org/10.1016/j.ebiom.2021.103391

APA

Staunstrup, L. M., Bager, C. L., Frederiksen, P., Helge, J. W., Brunak, S., Christiansen, C., & Karsdal, M. (2021). Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women. EBioMedicine, 68, [103391]. https://doi.org/10.1016/j.ebiom.2021.103391

Vancouver

Staunstrup LM, Bager CL, Frederiksen P, Helge JW, Brunak S, Christiansen C o.a. Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women. EBioMedicine. 2021;68. 103391. https://doi.org/10.1016/j.ebiom.2021.103391

Author

Staunstrup, Line Mærsk ; Bager, Cecilie Liv ; Frederiksen, Peder ; Helge, Jørn Wulff ; Brunak, Søren ; Christiansen, Claus ; Karsdal, Morten. / Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women. I: EBioMedicine. 2021 ; Bind 68.

Bibtex

@article{baf3f62704fa4fc3a44e187718364393,
title = "Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women",
abstract = "BACKGROUND: The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen. It is expressed by most descendants of the mesenchymal stem cells lineage, including adipocytes and fibroblasts, and have been proposed to be a central extracellular matrix hormone associated with several age-related diseases. We aimed to assess the association of endotrophin with chronic disease incidence and death in older women.METHODS: 5,602 elderly Danish women from the observational, prospective cohort: The Prospective Epidemiological Risk Factor (PERF) study were included in the analysis which covered baseline (BL) and follow-up (FU) 14 years later. An elastic net was used to investigate the relative importance of 58 variables to serum endotrophin-levels. 20 chronic diseases were defined on the basis of clinical variables available along with diagnoses extracted from both the National Patient Register, the National Diabetes Register and the Danish Cancer Registry. The cross-sectional associations between endotrophin-levels and these 17 chronic age-related diseases were investigated using logistic regression and a set-analysis explored disease-combinations within multimorbidity. The association of endotrophin with mortality was assessed by Cox proportional hazard models.FINDINGS: Formation of type III collagen (PRO-C3), age and creatine-levels were the most influential variables of endotrophin-levels. Several chronic diseases were significantly associated with endotrophin-levels independent of age and BMI including chronic kidney disease (BL OR=3.7, p < 0.001; FU OR = 7.9 p < 0.001), diabetes (BL OR = 1.5, p = 0.0015, FU OR=1.6, p = 0.004) and peripheral arterial disease (BL OR = 1.3, p = 0.029; FU OR=2.4, p < 0.001). Lastly, endotrophin-levels were significantly rising with number of morbidities (p < 0.001) and a predictor of death after adjusting for age and BMI (BL HR=1.95; FU HR = 2.00).INTERPRETATION: Endotrophin was associated with death and increased with number of morbidities. Endotrophin may be a central hormone of fibroblast that warrant investigation and possible targeted intervention in several chronic diseases.",
author = "Staunstrup, {Line M{\ae}rsk} and Bager, {Cecilie Liv} and Peder Frederiksen and Helge, {J{\o}rn Wulff} and S{\o}ren Brunak and Claus Christiansen and Morten Karsdal",
note = "Copyright {\textcopyright} 2021 The Author(s). Published by Elsevier B.V. All rights reserved.",
year = "2021",
doi = "10.1016/j.ebiom.2021.103391",
language = "English",
volume = "68",
journal = "EBioMedicine",
issn = "2352-3964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women

AU - Staunstrup, Line Mærsk

AU - Bager, Cecilie Liv

AU - Frederiksen, Peder

AU - Helge, Jørn Wulff

AU - Brunak, Søren

AU - Christiansen, Claus

AU - Karsdal, Morten

N1 - Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen. It is expressed by most descendants of the mesenchymal stem cells lineage, including adipocytes and fibroblasts, and have been proposed to be a central extracellular matrix hormone associated with several age-related diseases. We aimed to assess the association of endotrophin with chronic disease incidence and death in older women.METHODS: 5,602 elderly Danish women from the observational, prospective cohort: The Prospective Epidemiological Risk Factor (PERF) study were included in the analysis which covered baseline (BL) and follow-up (FU) 14 years later. An elastic net was used to investigate the relative importance of 58 variables to serum endotrophin-levels. 20 chronic diseases were defined on the basis of clinical variables available along with diagnoses extracted from both the National Patient Register, the National Diabetes Register and the Danish Cancer Registry. The cross-sectional associations between endotrophin-levels and these 17 chronic age-related diseases were investigated using logistic regression and a set-analysis explored disease-combinations within multimorbidity. The association of endotrophin with mortality was assessed by Cox proportional hazard models.FINDINGS: Formation of type III collagen (PRO-C3), age and creatine-levels were the most influential variables of endotrophin-levels. Several chronic diseases were significantly associated with endotrophin-levels independent of age and BMI including chronic kidney disease (BL OR=3.7, p < 0.001; FU OR = 7.9 p < 0.001), diabetes (BL OR = 1.5, p = 0.0015, FU OR=1.6, p = 0.004) and peripheral arterial disease (BL OR = 1.3, p = 0.029; FU OR=2.4, p < 0.001). Lastly, endotrophin-levels were significantly rising with number of morbidities (p < 0.001) and a predictor of death after adjusting for age and BMI (BL HR=1.95; FU HR = 2.00).INTERPRETATION: Endotrophin was associated with death and increased with number of morbidities. Endotrophin may be a central hormone of fibroblast that warrant investigation and possible targeted intervention in several chronic diseases.

AB - BACKGROUND: The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen. It is expressed by most descendants of the mesenchymal stem cells lineage, including adipocytes and fibroblasts, and have been proposed to be a central extracellular matrix hormone associated with several age-related diseases. We aimed to assess the association of endotrophin with chronic disease incidence and death in older women.METHODS: 5,602 elderly Danish women from the observational, prospective cohort: The Prospective Epidemiological Risk Factor (PERF) study were included in the analysis which covered baseline (BL) and follow-up (FU) 14 years later. An elastic net was used to investigate the relative importance of 58 variables to serum endotrophin-levels. 20 chronic diseases were defined on the basis of clinical variables available along with diagnoses extracted from both the National Patient Register, the National Diabetes Register and the Danish Cancer Registry. The cross-sectional associations between endotrophin-levels and these 17 chronic age-related diseases were investigated using logistic regression and a set-analysis explored disease-combinations within multimorbidity. The association of endotrophin with mortality was assessed by Cox proportional hazard models.FINDINGS: Formation of type III collagen (PRO-C3), age and creatine-levels were the most influential variables of endotrophin-levels. Several chronic diseases were significantly associated with endotrophin-levels independent of age and BMI including chronic kidney disease (BL OR=3.7, p < 0.001; FU OR = 7.9 p < 0.001), diabetes (BL OR = 1.5, p = 0.0015, FU OR=1.6, p = 0.004) and peripheral arterial disease (BL OR = 1.3, p = 0.029; FU OR=2.4, p < 0.001). Lastly, endotrophin-levels were significantly rising with number of morbidities (p < 0.001) and a predictor of death after adjusting for age and BMI (BL HR=1.95; FU HR = 2.00).INTERPRETATION: Endotrophin was associated with death and increased with number of morbidities. Endotrophin may be a central hormone of fibroblast that warrant investigation and possible targeted intervention in several chronic diseases.

U2 - 10.1016/j.ebiom.2021.103391

DO - 10.1016/j.ebiom.2021.103391

M3 - Journal article

C2 - 34044221

VL - 68

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

M1 - 103391

ER -

ID: 271975235