Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

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Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. / Mandrup, Camilla Maria; Egelund, Jon; Nyberg, Michael Permin; Enevoldsen, Lotte Hahn; Kjær, Andreas; Clemmensen, Andreas Ettrup; Nymark Christensen, Anders; Suetta, Charlotte; Frikke-Schmidt, Ruth; Enggaard Steenberg, Dorte; Wojtaszewski, Jørgen; Hellsten, Ylva; Stallknecht, Bente Merete.

I: Menopause , Bind 25, Nr. 2, 2018, s. 165-175.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mandrup, CM, Egelund, J, Nyberg, MP, Enevoldsen, LH, Kjær, A, Clemmensen, AE, Nymark Christensen, A, Suetta, C, Frikke-Schmidt, R, Enggaard Steenberg, D, Wojtaszewski, J, Hellsten, Y & Stallknecht, BM 2018, 'Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism', Menopause , bind 25, nr. 2, s. 165-175. https://doi.org/10.1097/GME.0000000000000981

APA

Mandrup, C. M., Egelund, J., Nyberg, M. P., Enevoldsen, L. H., Kjær, A., Clemmensen, A. E., ... Stallknecht, B. M. (2018). Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. Menopause , 25(2), 165-175. https://doi.org/10.1097/GME.0000000000000981

Vancouver

Mandrup CM, Egelund J, Nyberg MP, Enevoldsen LH, Kjær A, Clemmensen AE o.a. Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. Menopause . 2018;25(2):165-175. https://doi.org/10.1097/GME.0000000000000981

Author

Mandrup, Camilla Maria ; Egelund, Jon ; Nyberg, Michael Permin ; Enevoldsen, Lotte Hahn ; Kjær, Andreas ; Clemmensen, Andreas Ettrup ; Nymark Christensen, Anders ; Suetta, Charlotte ; Frikke-Schmidt, Ruth ; Enggaard Steenberg, Dorte ; Wojtaszewski, Jørgen ; Hellsten, Ylva ; Stallknecht, Bente Merete. / Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism. I: Menopause . 2018 ; Bind 25, Nr. 2. s. 165-175.

Bibtex

@article{d7afc9062f6643c7a1050987454d954a,
title = "Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism",
abstract = "OBJECTIVE: To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.METHODS: Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies.RESULTS: Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95{\%} confidence interval] 0.5 [0.2-0.9] kg, P < 0.01) and thigh muscle mass (0.2 [-0.1 to 0.6] kg, P < 0.01), and decreased fat percentage (1.0 [0.5-1.5]{\%}, P < 0.01) similarly in the two groups. The postmenopausal women had lower eMR in vastus lateralis muscle than the premenopausal women (-14.0 [-26.0 to -2.0] μmol/min/kg, P = 0.02), and tended to have lower eMR in femoral muscles (-11.2 [-22.7 to 0.4] μmol/min/kg, P = 0.06), and also GDR (-59.3 [-124.8 to 6.3] mg/min, P = 0.08), but increased similarly in both groups with training (eMR vastus lateralis muscle: 27.8 [19.6-36.0] μmol/min/kg, P < 0.01; eMR femoral muscle: 20.0 [13.1-26.7] μmol/min/kg, P < 0.01, respectively; GDR: 43.6 [10.4-76.9] mg/min, P = 0.01). Potential mechanisms underlying the training-induced increases in insulin sensitivity included increased expression of hexokinase (19.2 [5.0-24.7] AU, P = 0.02) and glycogen synthase (32.4 [15.0-49.8] AU, P < 0.01), and also increased insulin activation of Akt2 (20.6 [3.4-29.0], P = 0.03) and dephosphorylation of glycogen synthase (-41.8 [-82.9 to -0.7], P = 0.05).CONCLUSIONS: Insulin sensitivity was reduced in early postmenopausal women. However, postmenopausal women increased peripheral insulin sensitivity, skeletal muscle insulin-stimulated glucose uptake, and skeletal muscle mass to the same extent as premenopausal women after 3 months of high-intensity exercise training.",
keywords = "Glucose disposal, Insulin sensitivity, Insulin signaling, Menopause, Physical activity",
author = "Mandrup, {Camilla Maria} and Jon Egelund and Nyberg, {Michael Permin} and Enevoldsen, {Lotte Hahn} and Andreas Kj{\ae}r and Clemmensen, {Andreas Ettrup} and {Nymark Christensen}, Anders and Charlotte Suetta and Ruth Frikke-Schmidt and {Enggaard Steenberg}, Dorte and J{\o}rgen Wojtaszewski and Ylva Hellsten and Stallknecht, {Bente Merete}",
note = "CURIS 2018 NEXS 033 Obs! Fejl i DOI-link, og der er fejl i top-reference p{\aa} artiklens f{\o}rste side (2017)",
year = "2018",
doi = "10.1097/GME.0000000000000981",
language = "English",
volume = "25",
pages = "165--175",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

AU - Mandrup, Camilla Maria

AU - Egelund, Jon

AU - Nyberg, Michael Permin

AU - Enevoldsen, Lotte Hahn

AU - Kjær, Andreas

AU - Clemmensen, Andreas Ettrup

AU - Nymark Christensen, Anders

AU - Suetta, Charlotte

AU - Frikke-Schmidt, Ruth

AU - Enggaard Steenberg, Dorte

AU - Wojtaszewski, Jørgen

AU - Hellsten, Ylva

AU - Stallknecht, Bente Merete

N1 - CURIS 2018 NEXS 033 Obs! Fejl i DOI-link, og der er fejl i top-reference på artiklens første side (2017)

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.METHODS: Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies.RESULTS: Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P < 0.01) and thigh muscle mass (0.2 [-0.1 to 0.6] kg, P < 0.01), and decreased fat percentage (1.0 [0.5-1.5]%, P < 0.01) similarly in the two groups. The postmenopausal women had lower eMR in vastus lateralis muscle than the premenopausal women (-14.0 [-26.0 to -2.0] μmol/min/kg, P = 0.02), and tended to have lower eMR in femoral muscles (-11.2 [-22.7 to 0.4] μmol/min/kg, P = 0.06), and also GDR (-59.3 [-124.8 to 6.3] mg/min, P = 0.08), but increased similarly in both groups with training (eMR vastus lateralis muscle: 27.8 [19.6-36.0] μmol/min/kg, P < 0.01; eMR femoral muscle: 20.0 [13.1-26.7] μmol/min/kg, P < 0.01, respectively; GDR: 43.6 [10.4-76.9] mg/min, P = 0.01). Potential mechanisms underlying the training-induced increases in insulin sensitivity included increased expression of hexokinase (19.2 [5.0-24.7] AU, P = 0.02) and glycogen synthase (32.4 [15.0-49.8] AU, P < 0.01), and also increased insulin activation of Akt2 (20.6 [3.4-29.0], P = 0.03) and dephosphorylation of glycogen synthase (-41.8 [-82.9 to -0.7], P = 0.05).CONCLUSIONS: Insulin sensitivity was reduced in early postmenopausal women. However, postmenopausal women increased peripheral insulin sensitivity, skeletal muscle insulin-stimulated glucose uptake, and skeletal muscle mass to the same extent as premenopausal women after 3 months of high-intensity exercise training.

AB - OBJECTIVE: To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.METHODS: Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies.RESULTS: Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P < 0.01) and thigh muscle mass (0.2 [-0.1 to 0.6] kg, P < 0.01), and decreased fat percentage (1.0 [0.5-1.5]%, P < 0.01) similarly in the two groups. The postmenopausal women had lower eMR in vastus lateralis muscle than the premenopausal women (-14.0 [-26.0 to -2.0] μmol/min/kg, P = 0.02), and tended to have lower eMR in femoral muscles (-11.2 [-22.7 to 0.4] μmol/min/kg, P = 0.06), and also GDR (-59.3 [-124.8 to 6.3] mg/min, P = 0.08), but increased similarly in both groups with training (eMR vastus lateralis muscle: 27.8 [19.6-36.0] μmol/min/kg, P < 0.01; eMR femoral muscle: 20.0 [13.1-26.7] μmol/min/kg, P < 0.01, respectively; GDR: 43.6 [10.4-76.9] mg/min, P = 0.01). Potential mechanisms underlying the training-induced increases in insulin sensitivity included increased expression of hexokinase (19.2 [5.0-24.7] AU, P = 0.02) and glycogen synthase (32.4 [15.0-49.8] AU, P < 0.01), and also increased insulin activation of Akt2 (20.6 [3.4-29.0], P = 0.03) and dephosphorylation of glycogen synthase (-41.8 [-82.9 to -0.7], P = 0.05).CONCLUSIONS: Insulin sensitivity was reduced in early postmenopausal women. However, postmenopausal women increased peripheral insulin sensitivity, skeletal muscle insulin-stimulated glucose uptake, and skeletal muscle mass to the same extent as premenopausal women after 3 months of high-intensity exercise training.

KW - Glucose disposal

KW - Insulin sensitivity

KW - Insulin signaling

KW - Menopause

KW - Physical activity

U2 - 10.1097/GME.0000000000000981

DO - 10.1097/GME.0000000000000981

M3 - Journal article

VL - 25

SP - 165

EP - 175

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 2

ER -

ID: 184066693