Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women

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Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women. / Mandrup Jensen, Camilla Maria; Egelund, Jon; Nyberg, Michael Permin; Slingsby, Martina Helena; Andersen, Caroline Borup; Løgstrup, Sofie; Bangsbo, Jens; Suetta, Charlotte Arneboe; Stallknecht, Bente Merete; Hellsten, Ylva.

I: American Journal of Obstetrics and Gynecology, Bind 216, Nr. 4, 384, 2017, s. e1-e11.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mandrup Jensen, CM, Egelund, J, Nyberg, MP, Slingsby, MH, Andersen, CB, Løgstrup, S, Bangsbo, J, Suetta, CA, Stallknecht, BM & Hellsten, Y 2017, 'Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women', American Journal of Obstetrics and Gynecology, bind 216, nr. 4, 384, s. e1-e11. https://doi.org/10.1016/j.ajog.2016.12.017

APA

Mandrup Jensen, C. M., Egelund, J., Nyberg, M. P., Slingsby, M. H., Andersen, C. B., Løgstrup, S., Bangsbo, J., Suetta, C. A., Stallknecht, B. M., & Hellsten, Y. (2017). Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women. American Journal of Obstetrics and Gynecology, 216(4), e1-e11. [384]. https://doi.org/10.1016/j.ajog.2016.12.017

Vancouver

Mandrup Jensen CM, Egelund J, Nyberg MP, Slingsby MH, Andersen CB, Løgstrup S o.a. Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women. American Journal of Obstetrics and Gynecology. 2017;216(4):e1-e11. 384. https://doi.org/10.1016/j.ajog.2016.12.017

Author

Mandrup Jensen, Camilla Maria ; Egelund, Jon ; Nyberg, Michael Permin ; Slingsby, Martina Helena ; Andersen, Caroline Borup ; Løgstrup, Sofie ; Bangsbo, Jens ; Suetta, Charlotte Arneboe ; Stallknecht, Bente Merete ; Hellsten, Ylva. / Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women. I: American Journal of Obstetrics and Gynecology. 2017 ; Bind 216, Nr. 4. s. e1-e11.

Bibtex

@article{29185e74388b44ae917f80a9b4a78763,
title = "Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women",
abstract = "BACKGROUND: Menopause is associated with increased risk of cardiovascular disease and the causal factors have been proposed to be the loss of estrogen and the subsequent alterations of the hormonal milieu. However, which factors that contribute to the deterioration of cardio-metabolic health in postmenopausal women is debated as the menopausal transition is also associated with increased age and fat mass. Furthermore, indications of reduced cardio-metabolic adaptations to exercise in postmenopausal women add to the adverse health profile.OBJECTIVE: To evaluate risk factors for type 2 diabetes and cardiovascular disease in late pre- and early postmenopausal women, matched by age and body composition, and investigate the effect of high-intensity training.METHODS: A 3-month high-intensity aerobic training intervention, involving healthy, non-obese, late pre- (n=40) and early postmenopausal (n=39) women was conducted and antropometrics, body composition, blood pressure (BP), lipid profile, glucose tolerance and maximal oxygen consumption (VO2-max) were determined at baseline and after the intervention.RESULTS: At baseline, the groups matched in antropometrics and body composition, and only differed by 4.2 years in age (mean [95% confidence limits] 49.2 [48.5-49.9] vs. 53.4 [52.4-54.4] years). Time since last menstrual period for the postmenopausal women was (3.1 [2.6-3.7] years). Hormonal levels (estrogen, follicle stimulation hormone, luteinizing hormone) confirmed menopausal status. At baseline the postmenopausal women had higher total cholesterol (p<0.001), low density lipoprotein-cholesterol (LDL-C) (p<0.05) and high density lipoprotein-cholesterol (HDL-C) (p<0.001) than the premenopausal women. The training intervention reduced body weight (p<0.01), waist circumference (p<0.01) and improved body composition by increasing lean body mass (p<0.001) and decreasing fat mass (p<0.001) similarly in both groups. Moreover, training resulted in lower diastolic BP (p<0.05), resting heart rate (p<0.001), total cholesterol (p<0.01), LDL-C (p<0.01), total cholesterol/HDL-C index (p<0.01), and improved plasma insulin concentration during the oral glucose tolerance test (p<0.05) in both groups.CONCLUSION: Cardiovascular risk factors are similar in late pre- and early postmenopausal women, matched by age and body composition, with the exception that postmenopausal women have higher HDL-C and LDL-C levels. A three month intervention of high-intensity aerobic training reduces risk factors for type 2 diabetes and cardiovascular disease to a similar extent in late pre- and early postmenopausal women.",
keywords = "Faculty of Science, Cardiorespiratory fitness, Cardiovascular risk factors, Glucose metabolism, High-intensity exercise, Lipids, Menopause, Metabolic risk",
author = "{Mandrup Jensen}, {Camilla Maria} and Jon Egelund and Nyberg, {Michael Permin} and Slingsby, {Martina Helena} and Andersen, {Caroline Borup} and Sofie L{\o}gstrup and Jens Bangsbo and Suetta, {Charlotte Arneboe} and Stallknecht, {Bente Merete} and Ylva Hellsten",
note = "CURIS 2017 NEXS 107",
year = "2017",
doi = "10.1016/j.ajog.2016.12.017",
language = "English",
volume = "216",
pages = "e1--e11",
journal = "American Journal of Obstetrics & Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of high-intensity training on cardiovascular risk factors in pre- and postmenopausal women

AU - Mandrup Jensen, Camilla Maria

AU - Egelund, Jon

AU - Nyberg, Michael Permin

AU - Slingsby, Martina Helena

AU - Andersen, Caroline Borup

AU - Løgstrup, Sofie

AU - Bangsbo, Jens

AU - Suetta, Charlotte Arneboe

AU - Stallknecht, Bente Merete

AU - Hellsten, Ylva

N1 - CURIS 2017 NEXS 107

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Menopause is associated with increased risk of cardiovascular disease and the causal factors have been proposed to be the loss of estrogen and the subsequent alterations of the hormonal milieu. However, which factors that contribute to the deterioration of cardio-metabolic health in postmenopausal women is debated as the menopausal transition is also associated with increased age and fat mass. Furthermore, indications of reduced cardio-metabolic adaptations to exercise in postmenopausal women add to the adverse health profile.OBJECTIVE: To evaluate risk factors for type 2 diabetes and cardiovascular disease in late pre- and early postmenopausal women, matched by age and body composition, and investigate the effect of high-intensity training.METHODS: A 3-month high-intensity aerobic training intervention, involving healthy, non-obese, late pre- (n=40) and early postmenopausal (n=39) women was conducted and antropometrics, body composition, blood pressure (BP), lipid profile, glucose tolerance and maximal oxygen consumption (VO2-max) were determined at baseline and after the intervention.RESULTS: At baseline, the groups matched in antropometrics and body composition, and only differed by 4.2 years in age (mean [95% confidence limits] 49.2 [48.5-49.9] vs. 53.4 [52.4-54.4] years). Time since last menstrual period for the postmenopausal women was (3.1 [2.6-3.7] years). Hormonal levels (estrogen, follicle stimulation hormone, luteinizing hormone) confirmed menopausal status. At baseline the postmenopausal women had higher total cholesterol (p<0.001), low density lipoprotein-cholesterol (LDL-C) (p<0.05) and high density lipoprotein-cholesterol (HDL-C) (p<0.001) than the premenopausal women. The training intervention reduced body weight (p<0.01), waist circumference (p<0.01) and improved body composition by increasing lean body mass (p<0.001) and decreasing fat mass (p<0.001) similarly in both groups. Moreover, training resulted in lower diastolic BP (p<0.05), resting heart rate (p<0.001), total cholesterol (p<0.01), LDL-C (p<0.01), total cholesterol/HDL-C index (p<0.01), and improved plasma insulin concentration during the oral glucose tolerance test (p<0.05) in both groups.CONCLUSION: Cardiovascular risk factors are similar in late pre- and early postmenopausal women, matched by age and body composition, with the exception that postmenopausal women have higher HDL-C and LDL-C levels. A three month intervention of high-intensity aerobic training reduces risk factors for type 2 diabetes and cardiovascular disease to a similar extent in late pre- and early postmenopausal women.

AB - BACKGROUND: Menopause is associated with increased risk of cardiovascular disease and the causal factors have been proposed to be the loss of estrogen and the subsequent alterations of the hormonal milieu. However, which factors that contribute to the deterioration of cardio-metabolic health in postmenopausal women is debated as the menopausal transition is also associated with increased age and fat mass. Furthermore, indications of reduced cardio-metabolic adaptations to exercise in postmenopausal women add to the adverse health profile.OBJECTIVE: To evaluate risk factors for type 2 diabetes and cardiovascular disease in late pre- and early postmenopausal women, matched by age and body composition, and investigate the effect of high-intensity training.METHODS: A 3-month high-intensity aerobic training intervention, involving healthy, non-obese, late pre- (n=40) and early postmenopausal (n=39) women was conducted and antropometrics, body composition, blood pressure (BP), lipid profile, glucose tolerance and maximal oxygen consumption (VO2-max) were determined at baseline and after the intervention.RESULTS: At baseline, the groups matched in antropometrics and body composition, and only differed by 4.2 years in age (mean [95% confidence limits] 49.2 [48.5-49.9] vs. 53.4 [52.4-54.4] years). Time since last menstrual period for the postmenopausal women was (3.1 [2.6-3.7] years). Hormonal levels (estrogen, follicle stimulation hormone, luteinizing hormone) confirmed menopausal status. At baseline the postmenopausal women had higher total cholesterol (p<0.001), low density lipoprotein-cholesterol (LDL-C) (p<0.05) and high density lipoprotein-cholesterol (HDL-C) (p<0.001) than the premenopausal women. The training intervention reduced body weight (p<0.01), waist circumference (p<0.01) and improved body composition by increasing lean body mass (p<0.001) and decreasing fat mass (p<0.001) similarly in both groups. Moreover, training resulted in lower diastolic BP (p<0.05), resting heart rate (p<0.001), total cholesterol (p<0.01), LDL-C (p<0.01), total cholesterol/HDL-C index (p<0.01), and improved plasma insulin concentration during the oral glucose tolerance test (p<0.05) in both groups.CONCLUSION: Cardiovascular risk factors are similar in late pre- and early postmenopausal women, matched by age and body composition, with the exception that postmenopausal women have higher HDL-C and LDL-C levels. A three month intervention of high-intensity aerobic training reduces risk factors for type 2 diabetes and cardiovascular disease to a similar extent in late pre- and early postmenopausal women.

KW - Faculty of Science

KW - Cardiorespiratory fitness

KW - Cardiovascular risk factors

KW - Glucose metabolism

KW - High-intensity exercise

KW - Lipids

KW - Menopause

KW - Metabolic risk

U2 - 10.1016/j.ajog.2016.12.017

DO - 10.1016/j.ajog.2016.12.017

M3 - Journal article

C2 - 28024987

VL - 216

SP - e1-e11

JO - American Journal of Obstetrics & Gynecology

JF - American Journal of Obstetrics & Gynecology

SN - 0002-9378

IS - 4

M1 - 384

ER -

ID: 170805234