Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women

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Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women. / Mandrup, Camilla Maria; Roland, Caroline Borup; Egelund, Jon; Nyberg, Michael; Enevoldsen, Lotte Hahn; Kjær, Andreas; Clemmensen, Andreas; Christensen, Anders Nymark; Suetta, Charlotte; Frikke-Schmidt, Ruth; Utoft, Betina Bernhard; Kristensen, Jonas Møller; Wojtaszewski, Jørgen; Hellsten, Ylva; Stallknecht, Bente.

I: Frontiers in Sports and Active Living, Bind 2, 60, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mandrup, CM, Roland, CB, Egelund, J, Nyberg, M, Enevoldsen, LH, Kjær, A, Clemmensen, A, Christensen, AN, Suetta, C, Frikke-Schmidt, R, Utoft, BB, Kristensen, JM, Wojtaszewski, J, Hellsten, Y & Stallknecht, B 2020, 'Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women', Frontiers in Sports and Active Living, bind 2, 60. https://doi.org/10.3389/fspor.2020.00060

APA

Mandrup, C. M., Roland, C. B., Egelund, J., Nyberg, M., Enevoldsen, L. H., Kjær, A., Clemmensen, A., Christensen, A. N., Suetta, C., Frikke-Schmidt, R., Utoft, B. B., Kristensen, J. M., Wojtaszewski, J., Hellsten, Y., & Stallknecht, B. (2020). Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women. Frontiers in Sports and Active Living, 2, [60]. https://doi.org/10.3389/fspor.2020.00060

Vancouver

Mandrup CM, Roland CB, Egelund J, Nyberg M, Enevoldsen LH, Kjær A o.a. Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women. Frontiers in Sports and Active Living. 2020;2. 60. https://doi.org/10.3389/fspor.2020.00060

Author

Mandrup, Camilla Maria ; Roland, Caroline Borup ; Egelund, Jon ; Nyberg, Michael ; Enevoldsen, Lotte Hahn ; Kjær, Andreas ; Clemmensen, Andreas ; Christensen, Anders Nymark ; Suetta, Charlotte ; Frikke-Schmidt, Ruth ; Utoft, Betina Bernhard ; Kristensen, Jonas Møller ; Wojtaszewski, Jørgen ; Hellsten, Ylva ; Stallknecht, Bente. / Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women. I: Frontiers in Sports and Active Living. 2020 ; Bind 2.

Bibtex

@article{9b6af08adab24857b83392f8a9535ec4,
title = "Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women",
abstract = "The menopausal transition is accompanied by changes in adipose tissue storage, leading to an android body composition associated with increased risk of type 2 diabetes and cardiovascular disease in post-menopausal women. Estrogens probably affect local adipose tissue depots differently. We investigated how menopausal status and exercise training influence adipose tissue mass, adipose tissue insulin sensitivity and adipose tissue proteins associated with lipogenesis/lipolysis and mitochondrial function. Healthy, normal-weight pre- (n = 21) and post-menopausal (n = 20) women participated in high-intensity exercise training three times per week for 12 weeks. Adipose tissue distribution was determined by dual-energy x-ray absorptiometry and magnetic resonance imaging. Adipose tissue glucose uptake was assessed by positron emission tomography/computed tomography (PET/CT) by the glucose analog [18F]fluorodeoxyglucose ([18F]FDG) during continuous insulin infusion (40 mU·m-2·min-1). Protein content associated with insulin signaling, lipogenesis/lipolysis, and mitochondrial function were determined by western blotting in abdominal and femoral white adipose tissue biopsies. The mean age difference between the pre- and the post-menopausal women was 4.5 years. Exercise training reduced subcutaneous (~4%) and visceral (~6%) adipose tissue masses similarly in pre- and post-menopausal women. Insulin-stimulated glucose uptake, assessed by [18F]FDG-uptake during PET/CT, was similar in pre- and post-menopausal women in abdominal, gluteal, and femoral adipose tissue depots, despite skeletal muscle insulin resistance in post- compared to pre-menopausal women in the same cohort. Insulin-stimulated glucose uptake in adipose tissue depots was not changed after 3 months of high-intensity exercise training, but insulin sensitivity was higher in visceral compared to subcutaneous adipose tissue depots (~139%). Post-menopausal women exhibited increased hexokinase and adipose triglyceride lipase content in subcutaneous abdominal adipose tissue. Physical activity in the early post-menopausal years reduces abdominal obesity, but insulin sensitivity of adipose tissue seems unaffected by both menopausal status and physical activity.",
keywords = "Faculty of Science, White adipose tissue metabolism, Menopause, Insulin sensitivity, Lipid metabolism, Glucose metabolism, Mitochondrial enzymes",
author = "Mandrup, {Camilla Maria} and Roland, {Caroline Borup} and Jon Egelund and Michael Nyberg and Enevoldsen, {Lotte Hahn} and Andreas Kj{\ae}r and Andreas Clemmensen and Christensen, {Anders Nymark} and Charlotte Suetta and Ruth Frikke-Schmidt and Utoft, {Betina Bernhard} and Kristensen, {Jonas M{\o}ller} and J{\o}rgen Wojtaszewski and Ylva Hellsten and Bente Stallknecht",
note = "Copyright {\textcopyright} 2020 Mandrup, Roland, Egelund, Nyberg, Enevoldsen, Kjaer, Clemmensen, Christensen, Suetta, Frikke-Schmidt, Utoft, Kristensen, Wojtaszewski, Hellsten and Stallknecht.",
year = "2020",
doi = "10.3389/fspor.2020.00060",
language = "English",
volume = "2",
journal = "Frontiers in Sports and Active Living",
issn = "2624-9367",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women

AU - Mandrup, Camilla Maria

AU - Roland, Caroline Borup

AU - Egelund, Jon

AU - Nyberg, Michael

AU - Enevoldsen, Lotte Hahn

AU - Kjær, Andreas

AU - Clemmensen, Andreas

AU - Christensen, Anders Nymark

AU - Suetta, Charlotte

AU - Frikke-Schmidt, Ruth

AU - Utoft, Betina Bernhard

AU - Kristensen, Jonas Møller

AU - Wojtaszewski, Jørgen

AU - Hellsten, Ylva

AU - Stallknecht, Bente

N1 - Copyright © 2020 Mandrup, Roland, Egelund, Nyberg, Enevoldsen, Kjaer, Clemmensen, Christensen, Suetta, Frikke-Schmidt, Utoft, Kristensen, Wojtaszewski, Hellsten and Stallknecht.

PY - 2020

Y1 - 2020

N2 - The menopausal transition is accompanied by changes in adipose tissue storage, leading to an android body composition associated with increased risk of type 2 diabetes and cardiovascular disease in post-menopausal women. Estrogens probably affect local adipose tissue depots differently. We investigated how menopausal status and exercise training influence adipose tissue mass, adipose tissue insulin sensitivity and adipose tissue proteins associated with lipogenesis/lipolysis and mitochondrial function. Healthy, normal-weight pre- (n = 21) and post-menopausal (n = 20) women participated in high-intensity exercise training three times per week for 12 weeks. Adipose tissue distribution was determined by dual-energy x-ray absorptiometry and magnetic resonance imaging. Adipose tissue glucose uptake was assessed by positron emission tomography/computed tomography (PET/CT) by the glucose analog [18F]fluorodeoxyglucose ([18F]FDG) during continuous insulin infusion (40 mU·m-2·min-1). Protein content associated with insulin signaling, lipogenesis/lipolysis, and mitochondrial function were determined by western blotting in abdominal and femoral white adipose tissue biopsies. The mean age difference between the pre- and the post-menopausal women was 4.5 years. Exercise training reduced subcutaneous (~4%) and visceral (~6%) adipose tissue masses similarly in pre- and post-menopausal women. Insulin-stimulated glucose uptake, assessed by [18F]FDG-uptake during PET/CT, was similar in pre- and post-menopausal women in abdominal, gluteal, and femoral adipose tissue depots, despite skeletal muscle insulin resistance in post- compared to pre-menopausal women in the same cohort. Insulin-stimulated glucose uptake in adipose tissue depots was not changed after 3 months of high-intensity exercise training, but insulin sensitivity was higher in visceral compared to subcutaneous adipose tissue depots (~139%). Post-menopausal women exhibited increased hexokinase and adipose triglyceride lipase content in subcutaneous abdominal adipose tissue. Physical activity in the early post-menopausal years reduces abdominal obesity, but insulin sensitivity of adipose tissue seems unaffected by both menopausal status and physical activity.

AB - The menopausal transition is accompanied by changes in adipose tissue storage, leading to an android body composition associated with increased risk of type 2 diabetes and cardiovascular disease in post-menopausal women. Estrogens probably affect local adipose tissue depots differently. We investigated how menopausal status and exercise training influence adipose tissue mass, adipose tissue insulin sensitivity and adipose tissue proteins associated with lipogenesis/lipolysis and mitochondrial function. Healthy, normal-weight pre- (n = 21) and post-menopausal (n = 20) women participated in high-intensity exercise training three times per week for 12 weeks. Adipose tissue distribution was determined by dual-energy x-ray absorptiometry and magnetic resonance imaging. Adipose tissue glucose uptake was assessed by positron emission tomography/computed tomography (PET/CT) by the glucose analog [18F]fluorodeoxyglucose ([18F]FDG) during continuous insulin infusion (40 mU·m-2·min-1). Protein content associated with insulin signaling, lipogenesis/lipolysis, and mitochondrial function were determined by western blotting in abdominal and femoral white adipose tissue biopsies. The mean age difference between the pre- and the post-menopausal women was 4.5 years. Exercise training reduced subcutaneous (~4%) and visceral (~6%) adipose tissue masses similarly in pre- and post-menopausal women. Insulin-stimulated glucose uptake, assessed by [18F]FDG-uptake during PET/CT, was similar in pre- and post-menopausal women in abdominal, gluteal, and femoral adipose tissue depots, despite skeletal muscle insulin resistance in post- compared to pre-menopausal women in the same cohort. Insulin-stimulated glucose uptake in adipose tissue depots was not changed after 3 months of high-intensity exercise training, but insulin sensitivity was higher in visceral compared to subcutaneous adipose tissue depots (~139%). Post-menopausal women exhibited increased hexokinase and adipose triglyceride lipase content in subcutaneous abdominal adipose tissue. Physical activity in the early post-menopausal years reduces abdominal obesity, but insulin sensitivity of adipose tissue seems unaffected by both menopausal status and physical activity.

KW - Faculty of Science

KW - White adipose tissue metabolism

KW - Menopause

KW - Insulin sensitivity

KW - Lipid metabolism

KW - Glucose metabolism

KW - Mitochondrial enzymes

U2 - 10.3389/fspor.2020.00060

DO - 10.3389/fspor.2020.00060

M3 - Journal article

C2 - 33345051

VL - 2

JO - Frontiers in Sports and Active Living

JF - Frontiers in Sports and Active Living

SN - 2624-9367

M1 - 60

ER -

ID: 254470068