Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings

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Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings. / Weber, Philip; Thomsen, Mads Norvin; Skytte, Mads Juul; Samkani, Amirsalar; Carl, Martin Hansen; Astrup, Arne; Frystyk, Jan; Holst, Jens Juul; Hartmann, Bolette; Madsbad, Sten; Magkos, Faidon; Krarup, Thure; Haugaard, Steen Bendix.

I: Nutrients, Bind 14, Nr. 24, 5244, 2022.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Weber, P, Thomsen, MN, Skytte, MJ, Samkani, A, Carl, MH, Astrup, A, Frystyk, J, Holst, JJ, Hartmann, B, Madsbad, S, Magkos, F, Krarup, T & Haugaard, SB 2022, 'Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings', Nutrients, bind 14, nr. 24, 5244. https://doi.org/10.3390/nu14245244

APA

Weber, P., Thomsen, M. N., Skytte, M. J., Samkani, A., Carl, M. H., Astrup, A., Frystyk, J., Holst, J. J., Hartmann, B., Madsbad, S., Magkos, F., Krarup, T., & Haugaard, S. B. (2022). Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings. Nutrients, 14(24), [5244]. https://doi.org/10.3390/nu14245244

Vancouver

Weber P, Thomsen MN, Skytte MJ, Samkani A, Carl MH, Astrup A o.a. Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings. Nutrients. 2022;14(24). 5244. https://doi.org/10.3390/nu14245244

Author

Weber, Philip ; Thomsen, Mads Norvin ; Skytte, Mads Juul ; Samkani, Amirsalar ; Carl, Martin Hansen ; Astrup, Arne ; Frystyk, Jan ; Holst, Jens Juul ; Hartmann, Bolette ; Madsbad, Sten ; Magkos, Faidon ; Krarup, Thure ; Haugaard, Steen Bendix. / Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings. I: Nutrients. 2022 ; Bind 14, Nr. 24.

Bibtex

@article{425e122ce1eb4eb6824b6c5b2a45d01e,
title = "Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings",
abstract = "A fully provided, hypocaloric, carbohydrate-reduced high-protein (CRHP) diet compared to a hypocaloric conventional diabetes (CD) diet for 6 weeks improved glycemic control to a greater extent in face of an intended 6% weight loss in individuals with type 2 diabetes mellitus (T2DM). The present 24-week extension of that study reports on the efficacy of CRHP and CD diets in a real-life setting. Sixty-five individuals with T2DM who completed the initial 6-week fully provided diet period (% energy from carbohydrate, protein, and fat was 30/30/40 in CRHP, and 50/17/33 in CD) continued a free-living, dietician guided 24-week period of which 59 individuals completed. The CRHP compared to CD group reported a 4% lower carbohydrate intake and had higher urea excretion by 22% (both p ≤ 0.05) at week 30, suggesting less difference in carbohydrate and protein intake between groups during the 24-week extension compared to week 6. The loss of body weight during the initial 6 weeks was maintained in both groups during the 24-week extension (−5.5 ± 4.5 and −4.6 ± 4.8 kg) as well as HbA1c (−8.4 ± 6.2 and −8.4 ± 6.9 mmol/mol) with no significant differences between groups. The additional benefits on glucoregulation harnessed by carbohydrate restriction under full diet provision for 6 weeks combined with titrated weight loss could not be maintained in a real-life setting of self-prepared diet aiming on similar diets for 6 months.",
keywords = "Carbohydrate restriction, Glucose metabolism, Lipid metabolism, Macronutrients, Type 2 diabetes",
author = "Philip Weber and Thomsen, {Mads Norvin} and Skytte, {Mads Juul} and Amirsalar Samkani and Carl, {Martin Hansen} and Arne Astrup and Jan Frystyk and Holst, {Jens Juul} and Bolette Hartmann and Sten Madsbad and Faidon Magkos and Thure Krarup and Haugaard, {Steen Bendix}",
note = "Funding Information: The current study was supported by grants from Arla Foods amba, The Danish Dairy Research Foundation, The Novo Nordisk Foundation and Copenhagen University Hospital Bispebjerg Frederiksberg. The funders were not involved in the design, conduct, and interpretation of the study. No restrictions regarding publication were imposed by any party. Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
doi = "10.3390/nu14245244",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "24",

}

RIS

TY - JOUR

T1 - Effects of carbohydrate restriction on body weight and glycemic control in individuals with type 2 diabetes: A randomized controlled trial of efficacy in real-life settings

AU - Weber, Philip

AU - Thomsen, Mads Norvin

AU - Skytte, Mads Juul

AU - Samkani, Amirsalar

AU - Carl, Martin Hansen

AU - Astrup, Arne

AU - Frystyk, Jan

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Madsbad, Sten

AU - Magkos, Faidon

AU - Krarup, Thure

AU - Haugaard, Steen Bendix

N1 - Funding Information: The current study was supported by grants from Arla Foods amba, The Danish Dairy Research Foundation, The Novo Nordisk Foundation and Copenhagen University Hospital Bispebjerg Frederiksberg. The funders were not involved in the design, conduct, and interpretation of the study. No restrictions regarding publication were imposed by any party. Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - A fully provided, hypocaloric, carbohydrate-reduced high-protein (CRHP) diet compared to a hypocaloric conventional diabetes (CD) diet for 6 weeks improved glycemic control to a greater extent in face of an intended 6% weight loss in individuals with type 2 diabetes mellitus (T2DM). The present 24-week extension of that study reports on the efficacy of CRHP and CD diets in a real-life setting. Sixty-five individuals with T2DM who completed the initial 6-week fully provided diet period (% energy from carbohydrate, protein, and fat was 30/30/40 in CRHP, and 50/17/33 in CD) continued a free-living, dietician guided 24-week period of which 59 individuals completed. The CRHP compared to CD group reported a 4% lower carbohydrate intake and had higher urea excretion by 22% (both p ≤ 0.05) at week 30, suggesting less difference in carbohydrate and protein intake between groups during the 24-week extension compared to week 6. The loss of body weight during the initial 6 weeks was maintained in both groups during the 24-week extension (−5.5 ± 4.5 and −4.6 ± 4.8 kg) as well as HbA1c (−8.4 ± 6.2 and −8.4 ± 6.9 mmol/mol) with no significant differences between groups. The additional benefits on glucoregulation harnessed by carbohydrate restriction under full diet provision for 6 weeks combined with titrated weight loss could not be maintained in a real-life setting of self-prepared diet aiming on similar diets for 6 months.

AB - A fully provided, hypocaloric, carbohydrate-reduced high-protein (CRHP) diet compared to a hypocaloric conventional diabetes (CD) diet for 6 weeks improved glycemic control to a greater extent in face of an intended 6% weight loss in individuals with type 2 diabetes mellitus (T2DM). The present 24-week extension of that study reports on the efficacy of CRHP and CD diets in a real-life setting. Sixty-five individuals with T2DM who completed the initial 6-week fully provided diet period (% energy from carbohydrate, protein, and fat was 30/30/40 in CRHP, and 50/17/33 in CD) continued a free-living, dietician guided 24-week period of which 59 individuals completed. The CRHP compared to CD group reported a 4% lower carbohydrate intake and had higher urea excretion by 22% (both p ≤ 0.05) at week 30, suggesting less difference in carbohydrate and protein intake between groups during the 24-week extension compared to week 6. The loss of body weight during the initial 6 weeks was maintained in both groups during the 24-week extension (−5.5 ± 4.5 and −4.6 ± 4.8 kg) as well as HbA1c (−8.4 ± 6.2 and −8.4 ± 6.9 mmol/mol) with no significant differences between groups. The additional benefits on glucoregulation harnessed by carbohydrate restriction under full diet provision for 6 weeks combined with titrated weight loss could not be maintained in a real-life setting of self-prepared diet aiming on similar diets for 6 months.

KW - Carbohydrate restriction

KW - Glucose metabolism

KW - Lipid metabolism

KW - Macronutrients

KW - Type 2 diabetes

U2 - 10.3390/nu14245244

DO - 10.3390/nu14245244

M3 - Journal article

C2 - 36558403

AN - SCOPUS:85144531021

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 24

M1 - 5244

ER -

ID: 330838122