Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes : a secondary analysis of a randomised clinical trial. / Johansen, Mette Y.; Karstoft, Kristian; MacDonald, Christopher S.; Hansen, Katrine B.; Ellingsgaard, Helga; Hartmann, Bolette; Albrechtsen, Nicolai J. Wewer; Vaag, Allan A.; Holst, Jens J.; Pedersen, Bente K.; Ried-Larsen, Mathias.

I: Diabetologia, Bind 63, 2020, s. 2410-2422.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Johansen, MY, Karstoft, K, MacDonald, CS, Hansen, KB, Ellingsgaard, H, Hartmann, B, Albrechtsen, NJW, Vaag, AA, Holst, JJ, Pedersen, BK & Ried-Larsen, M 2020, 'Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial', Diabetologia, bind 63, s. 2410-2422. https://doi.org/10.1007/s00125-020-05249-7

APA

Johansen, M. Y., Karstoft, K., MacDonald, C. S., Hansen, K. B., Ellingsgaard, H., Hartmann, B., Albrechtsen, N. J. W., Vaag, A. A., Holst, J. J., Pedersen, B. K., & Ried-Larsen, M. (2020). Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial. Diabetologia, 63, 2410-2422. https://doi.org/10.1007/s00125-020-05249-7

Vancouver

Johansen MY, Karstoft K, MacDonald CS, Hansen KB, Ellingsgaard H, Hartmann B o.a. Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial. Diabetologia. 2020;63:2410-2422. https://doi.org/10.1007/s00125-020-05249-7

Author

Johansen, Mette Y. ; Karstoft, Kristian ; MacDonald, Christopher S. ; Hansen, Katrine B. ; Ellingsgaard, Helga ; Hartmann, Bolette ; Albrechtsen, Nicolai J. Wewer ; Vaag, Allan A. ; Holst, Jens J. ; Pedersen, Bente K. ; Ried-Larsen, Mathias. / Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes : a secondary analysis of a randomised clinical trial. I: Diabetologia. 2020 ; Bind 63. s. 2410-2422.

Bibtex

@article{9f828a81f4db44e2855711d58fff19e8,
title = "Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial",
abstract = "Aims/hypothesis The aim was to investigate whether an intensive lifestyle intervention, with high volumes of exercise, improves beta cell function and to explore the role of low-grade inflammation and body weight.Methods This was a randomised, assessor-blinded, controlled trial. Ninety-eight individuals with type 2 diabetes (durationResults At baseline, individuals were 54.8 years (SD 8.9), 47% women, type 2 diabetes duration 5 years (IQR 3-8) and HbA(1c)was 49.3 mmol/mol (SD 9.2); 6.7% (SD 0.8). The intensive lifestyle group showed 40% greater improvement in the disposition index compared with the standard care group (ratio of geometric mean change [RGM] 1.40 [95% CI 1.01, 1.94]) from baseline to 12 months' follow-up. Plasma concentration of IL-1 receptor antagonist (IL-1ra) decreased 30% more in the intensive lifestyle group compared with the standard care group (RGM 0.70 [95% CI 0.58, 0.85]). Statistical single mediation analysis estimated that the intervention effect on the change in IL-1ra and the change in body weight explained to a similar extent (59%) the variance in the intervention effect on the disposition index.Conclusions/interpretation Our findings show that incorporating an intensive lifestyle intervention, with high volumes of exercise, in individuals with type 2 diabetes has the potential to improve beta cell function, associated with a decrease in low-grade inflammation and/or body weight.",
keywords = "Beta cell function, Exercise, Glycaemic control, Insulin secretion, Insulin sensitivity, Low-grade inflammation, Type 2 diabetes, BETA-CELL FUNCTION, ORAL GLUCOSE-TOLERANCE, INSULIN SENSITIVITY, WEIGHT-LOSS, EXERCISE, RESISTANCE, MELLITUS, MUSCLE",
author = "Johansen, {Mette Y.} and Kristian Karstoft and MacDonald, {Christopher S.} and Hansen, {Katrine B.} and Helga Ellingsgaard and Bolette Hartmann and Albrechtsen, {Nicolai J. Wewer} and Vaag, {Allan A.} and Holst, {Jens J.} and Pedersen, {Bente K.} and Mathias Ried-Larsen",
year = "2020",
doi = "10.1007/s00125-020-05249-7",
language = "English",
volume = "63",
pages = "2410--2422",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes

T2 - a secondary analysis of a randomised clinical trial

AU - Johansen, Mette Y.

AU - Karstoft, Kristian

AU - MacDonald, Christopher S.

AU - Hansen, Katrine B.

AU - Ellingsgaard, Helga

AU - Hartmann, Bolette

AU - Albrechtsen, Nicolai J. Wewer

AU - Vaag, Allan A.

AU - Holst, Jens J.

AU - Pedersen, Bente K.

AU - Ried-Larsen, Mathias

PY - 2020

Y1 - 2020

N2 - Aims/hypothesis The aim was to investigate whether an intensive lifestyle intervention, with high volumes of exercise, improves beta cell function and to explore the role of low-grade inflammation and body weight.Methods This was a randomised, assessor-blinded, controlled trial. Ninety-eight individuals with type 2 diabetes (durationResults At baseline, individuals were 54.8 years (SD 8.9), 47% women, type 2 diabetes duration 5 years (IQR 3-8) and HbA(1c)was 49.3 mmol/mol (SD 9.2); 6.7% (SD 0.8). The intensive lifestyle group showed 40% greater improvement in the disposition index compared with the standard care group (ratio of geometric mean change [RGM] 1.40 [95% CI 1.01, 1.94]) from baseline to 12 months' follow-up. Plasma concentration of IL-1 receptor antagonist (IL-1ra) decreased 30% more in the intensive lifestyle group compared with the standard care group (RGM 0.70 [95% CI 0.58, 0.85]). Statistical single mediation analysis estimated that the intervention effect on the change in IL-1ra and the change in body weight explained to a similar extent (59%) the variance in the intervention effect on the disposition index.Conclusions/interpretation Our findings show that incorporating an intensive lifestyle intervention, with high volumes of exercise, in individuals with type 2 diabetes has the potential to improve beta cell function, associated with a decrease in low-grade inflammation and/or body weight.

AB - Aims/hypothesis The aim was to investigate whether an intensive lifestyle intervention, with high volumes of exercise, improves beta cell function and to explore the role of low-grade inflammation and body weight.Methods This was a randomised, assessor-blinded, controlled trial. Ninety-eight individuals with type 2 diabetes (durationResults At baseline, individuals were 54.8 years (SD 8.9), 47% women, type 2 diabetes duration 5 years (IQR 3-8) and HbA(1c)was 49.3 mmol/mol (SD 9.2); 6.7% (SD 0.8). The intensive lifestyle group showed 40% greater improvement in the disposition index compared with the standard care group (ratio of geometric mean change [RGM] 1.40 [95% CI 1.01, 1.94]) from baseline to 12 months' follow-up. Plasma concentration of IL-1 receptor antagonist (IL-1ra) decreased 30% more in the intensive lifestyle group compared with the standard care group (RGM 0.70 [95% CI 0.58, 0.85]). Statistical single mediation analysis estimated that the intervention effect on the change in IL-1ra and the change in body weight explained to a similar extent (59%) the variance in the intervention effect on the disposition index.Conclusions/interpretation Our findings show that incorporating an intensive lifestyle intervention, with high volumes of exercise, in individuals with type 2 diabetes has the potential to improve beta cell function, associated with a decrease in low-grade inflammation and/or body weight.

KW - Beta cell function

KW - Exercise

KW - Glycaemic control

KW - Insulin secretion

KW - Insulin sensitivity

KW - Low-grade inflammation

KW - Type 2 diabetes

KW - BETA-CELL FUNCTION

KW - ORAL GLUCOSE-TOLERANCE

KW - INSULIN SENSITIVITY

KW - WEIGHT-LOSS

KW - EXERCISE

KW - RESISTANCE

KW - MELLITUS

KW - MUSCLE

U2 - 10.1007/s00125-020-05249-7

DO - 10.1007/s00125-020-05249-7

M3 - Journal article

C2 - 32816096

VL - 63

SP - 2410

EP - 2422

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -

ID: 248026609