Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity

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Jonas Salling Quist, Martin Bæk Blond, Anne Sofie Gram, Carina Bjørnskov Steenholt, Charlotte Janus, Jens J Holst, Jens F Rehfeld, Anders Mikael Sjödin, Bente Stallknecht, Mads Rosenkilde

Acute exercise is associated with a transient suppression of appetite. Effects of regular exercise on appetite are not well understood. We aimed to determine effects of active commuting and leisure-time exercise on appetite. 130 physically inactive women and men (20-45 years) with overweight and obesity were randomized to 6 months of habitual lifestyle (CON, n=18), active commuting (BIKE, n=35), or leisure-time exercise of moderate (MOD, 50% VO2peak-reserve, n=39) or vigorous intensity (VIG, 70% VO2peak-reserve, n=38). Appetite ratings, acylated ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and glucagon were assessed in the basal state and in response to meal and exercise challenges at baseline, 3, and 6 months. Ad libitum energy intake was determined during test meals. Data from 90 participants ( per protocol) were available and results are comparisons with CON. At 3 months, ad libitum energy intake was lower in VIG (-22%, p<0.01), basal glucagon was lower in BIKE (p<0.05) and VIG (p=0.01), and postprandial ratings of prospective food consumption were lower in MOD (p=0.02) and VIG (p<0.001). In VIG, ratings of hunger (p=0.01) and prospective food consumption (p=0.03) were lower following acute exercise at 3 months. At 6 months, basal and postprandial GLP-1 were higher (p≤0.04) whereas post-exercise PYY was lower (p=0.03) in VIG, and post-exercise CCK was lower in BIKE (p=0.03). Vigorous intensity exercise training leads to a transient suppression of energy intake and subjective appetite (3 months) but a more long-term increase in basal and postprandial GLP-1 (6 months) in individuals with overweight and obesity.

OriginalsprogEngelsk
TidsskriftJournal of Applied Physiology
Vol/bind126
Udgave nummer4
Sider (fra-til)941-951
ISSN8750-7587
DOI
StatusUdgivet - 2019

Bibliografisk note

CURIS 2019 NEXS 143

ID: 214749159