Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate

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Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate. / Yafasova, Adelina; Mandrup, Camilla Maria; Egelund, Jon; Nyberg, Michael Permin; Stallknecht, Bente; Hellsten, Ylva; Nielsen, Lars Bo; Christoffersen, Christina.

I: Journal of Applied Physiology, Bind 126, Nr. 1, 2019, s. 214-220.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Yafasova, A, Mandrup, CM, Egelund, J, Nyberg, MP, Stallknecht, B, Hellsten, Y, Nielsen, LB & Christoffersen, C 2019, 'Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate', Journal of Applied Physiology, bind 126, nr. 1, s. 214-220. https://doi.org/10.1152/japplphysiol.00527.2018

APA

Yafasova, A., Mandrup, C. M., Egelund, J., Nyberg, M. P., Stallknecht, B., Hellsten, Y., ... Christoffersen, C. (2019). Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate. Journal of Applied Physiology, 126(1), 214-220. https://doi.org/10.1152/japplphysiol.00527.2018

Vancouver

Yafasova A, Mandrup CM, Egelund J, Nyberg MP, Stallknecht B, Hellsten Y o.a. Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate. Journal of Applied Physiology. 2019;126(1):214-220. https://doi.org/10.1152/japplphysiol.00527.2018

Author

Yafasova, Adelina ; Mandrup, Camilla Maria ; Egelund, Jon ; Nyberg, Michael Permin ; Stallknecht, Bente ; Hellsten, Ylva ; Nielsen, Lars Bo ; Christoffersen, Christina. / Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate. I: Journal of Applied Physiology. 2019 ; Bind 126, Nr. 1. s. 214-220.

Bibtex

@article{7cc044f524194c7d92bf98794e6b9037,
title = "Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate",
abstract = "Objective: The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis.Methods: Healthy, late premenopausal (n=38, age 49.2±2) and recent postmenopausal (n=37, age 53.3±3) women from the Copenhagen Women Study participated in a three-month, aerobic high-intensity exercise intervention.Results: Before training, plasma apoM was higher in postmenopausal (1.08±0.2 µmol/l (mean±SD)) compared to premenopausal (0.82±0.2 µmol/l) women (p<0.0001). Plasma S1P was similar in the two groups (0.44±0.1 and 0.46±0.1 µmol/l, respectively). Hence, the pre-training S1P/apoM ratio was 26{\%} lower in postmenopausal than premenopausal women (p<0.0001). After the training program, plasma apoM increased from 0.82±0.2 to 0.90±0.3 µmol/l in premenopausal women and from 1.08±0.2 to 1.16±0.3 µmol/l in postmenopausal women (p<0.05). Plasma S1P increased from 0.44±0.1 to 0.47±0.1 µmol/l in premenopausal women and from 0.46±0.1 to 0.48±0.1 µmol/l in postmenopausal women (p<0.05).Conclusions: The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations, and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status.",
keywords = "Faculty of Science, Apolipoproteins, Lipoprotein metabolism, Lipids, Sphingolipids, Atherosclerosis, Menopausal transition, Cardiovascular training",
author = "Adelina Yafasova and Mandrup, {Camilla Maria} and Jon Egelund and Nyberg, {Michael Permin} and Bente Stallknecht and Ylva Hellsten and Nielsen, {Lars Bo} and Christina Christoffersen",
note = "CURIS 2019 NEXS 044",
year = "2019",
doi = "10.1152/japplphysiol.00527.2018",
language = "English",
volume = "126",
pages = "214--220",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate

AU - Yafasova, Adelina

AU - Mandrup, Camilla Maria

AU - Egelund, Jon

AU - Nyberg, Michael Permin

AU - Stallknecht, Bente

AU - Hellsten, Ylva

AU - Nielsen, Lars Bo

AU - Christoffersen, Christina

N1 - CURIS 2019 NEXS 044

PY - 2019

Y1 - 2019

N2 - Objective: The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis.Methods: Healthy, late premenopausal (n=38, age 49.2±2) and recent postmenopausal (n=37, age 53.3±3) women from the Copenhagen Women Study participated in a three-month, aerobic high-intensity exercise intervention.Results: Before training, plasma apoM was higher in postmenopausal (1.08±0.2 µmol/l (mean±SD)) compared to premenopausal (0.82±0.2 µmol/l) women (p<0.0001). Plasma S1P was similar in the two groups (0.44±0.1 and 0.46±0.1 µmol/l, respectively). Hence, the pre-training S1P/apoM ratio was 26% lower in postmenopausal than premenopausal women (p<0.0001). After the training program, plasma apoM increased from 0.82±0.2 to 0.90±0.3 µmol/l in premenopausal women and from 1.08±0.2 to 1.16±0.3 µmol/l in postmenopausal women (p<0.05). Plasma S1P increased from 0.44±0.1 to 0.47±0.1 µmol/l in premenopausal women and from 0.46±0.1 to 0.48±0.1 µmol/l in postmenopausal women (p<0.05).Conclusions: The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations, and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status.

AB - Objective: The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis.Methods: Healthy, late premenopausal (n=38, age 49.2±2) and recent postmenopausal (n=37, age 53.3±3) women from the Copenhagen Women Study participated in a three-month, aerobic high-intensity exercise intervention.Results: Before training, plasma apoM was higher in postmenopausal (1.08±0.2 µmol/l (mean±SD)) compared to premenopausal (0.82±0.2 µmol/l) women (p<0.0001). Plasma S1P was similar in the two groups (0.44±0.1 and 0.46±0.1 µmol/l, respectively). Hence, the pre-training S1P/apoM ratio was 26% lower in postmenopausal than premenopausal women (p<0.0001). After the training program, plasma apoM increased from 0.82±0.2 to 0.90±0.3 µmol/l in premenopausal women and from 1.08±0.2 to 1.16±0.3 µmol/l in postmenopausal women (p<0.05). Plasma S1P increased from 0.44±0.1 to 0.47±0.1 µmol/l in premenopausal women and from 0.46±0.1 to 0.48±0.1 µmol/l in postmenopausal women (p<0.05).Conclusions: The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations, and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status.

KW - Faculty of Science

KW - Apolipoproteins

KW - Lipoprotein metabolism

KW - Lipids

KW - Sphingolipids

KW - Atherosclerosis

KW - Menopausal transition

KW - Cardiovascular training

U2 - 10.1152/japplphysiol.00527.2018

DO - 10.1152/japplphysiol.00527.2018

M3 - Journal article

C2 - 30433864

VL - 126

SP - 214

EP - 220

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

ID: 209056148