Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation

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Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation. / Hesselkilde, Eva Z.; Carstensen, Helena; Haugaard, Maria M.; Carlson, Jonas; Pehrson, Steen; Jespersen, Thomas; Buhl, Rikke; Platonov, Pyotr G.

I: B M C Cardiovascular Disorders, Bind 17, 289, 12.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hesselkilde, EZ, Carstensen, H, Haugaard, MM, Carlson, J, Pehrson, S, Jespersen, T, Buhl, R & Platonov, PG 2017, 'Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation', B M C Cardiovascular Disorders, bind 17, 289. https://doi.org/10.1186/s12872-017-0720-1

APA

Hesselkilde, E. Z., Carstensen, H., Haugaard, M. M., Carlson, J., Pehrson, S., Jespersen, T., ... Platonov, P. G. (2017). Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation. B M C Cardiovascular Disorders, 17, [289]. https://doi.org/10.1186/s12872-017-0720-1

Vancouver

Hesselkilde EZ, Carstensen H, Haugaard MM, Carlson J, Pehrson S, Jespersen T o.a. Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation. B M C Cardiovascular Disorders. 2017 dec;17. 289. https://doi.org/10.1186/s12872-017-0720-1

Author

Hesselkilde, Eva Z. ; Carstensen, Helena ; Haugaard, Maria M. ; Carlson, Jonas ; Pehrson, Steen ; Jespersen, Thomas ; Buhl, Rikke ; Platonov, Pyotr G. / Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation. I: B M C Cardiovascular Disorders. 2017 ; Bind 17.

Bibtex

@article{c305721fd76145a0aaaa5b121a3a55e1,
title = "Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation",
abstract = "Background Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported. Aim The aim was to study characteristics of induced AF and its modification by flecainide. Methods The study group consisted on 3 horses with spontaneous persistent AF and 13 with pace-induced AF. Seven horses were treated with saline (control) and eight with flecainide (2 mg/kg). ECGs were analysed using spatiotemporal cancellation of QRST complexes and calculation of AFR from the residual atrial signal. Results At AF onset, AFR was 295 ± 52 fibrillations per minute (fpm) in the horses with induced AF treated with flecainide, 269 ± 36 fpm in the control group (ns), and 364 ± 26 fpm in the horses with spontaneous persistent AF (P < 0.05 compared to the control group). Flecainide caused a decrease in AFR in all animals and restored sinus rhythm in the animals with induced AF. In the control animals, AFR increased from 269 ± 36 fpm to a plateau of 313 ± 14 fpm before decreasing to 288 ± 28 fpm during the last 10{\%} of the AF episodes preceding spontaneous conversion (P < 0.05). Conclusion AFR in horses with induced AF resembles AFR in humans with paroxysmal AF. Flecainide caused a rapid decrease in AFR in all horses, further supporting the method to be a non-invasive technique to study the effect of antiarrhythmic compounds.",
keywords = "Antiarrhythmic drug, Atrial electrophysiology, Atrial fibrillation, Atrial fibrillatory rate, Animal model, Equine, Flecainide, Horse, Programmed electrical stimulation",
author = "Hesselkilde, {Eva Z.} and Helena Carstensen and Haugaard, {Maria M.} and Jonas Carlson and Steen Pehrson and Thomas Jespersen and Rikke Buhl and Platonov, {Pyotr G.}",
year = "2017",
month = "12",
doi = "10.1186/s12872-017-0720-1",
language = "English",
volume = "17",
journal = "B M C Cardiovascular Disorders",
issn = "1471-2261",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation

AU - Hesselkilde, Eva Z.

AU - Carstensen, Helena

AU - Haugaard, Maria M.

AU - Carlson, Jonas

AU - Pehrson, Steen

AU - Jespersen, Thomas

AU - Buhl, Rikke

AU - Platonov, Pyotr G.

PY - 2017/12

Y1 - 2017/12

N2 - Background Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported. Aim The aim was to study characteristics of induced AF and its modification by flecainide. Methods The study group consisted on 3 horses with spontaneous persistent AF and 13 with pace-induced AF. Seven horses were treated with saline (control) and eight with flecainide (2 mg/kg). ECGs were analysed using spatiotemporal cancellation of QRST complexes and calculation of AFR from the residual atrial signal. Results At AF onset, AFR was 295 ± 52 fibrillations per minute (fpm) in the horses with induced AF treated with flecainide, 269 ± 36 fpm in the control group (ns), and 364 ± 26 fpm in the horses with spontaneous persistent AF (P < 0.05 compared to the control group). Flecainide caused a decrease in AFR in all animals and restored sinus rhythm in the animals with induced AF. In the control animals, AFR increased from 269 ± 36 fpm to a plateau of 313 ± 14 fpm before decreasing to 288 ± 28 fpm during the last 10% of the AF episodes preceding spontaneous conversion (P < 0.05). Conclusion AFR in horses with induced AF resembles AFR in humans with paroxysmal AF. Flecainide caused a rapid decrease in AFR in all horses, further supporting the method to be a non-invasive technique to study the effect of antiarrhythmic compounds.

AB - Background Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported. Aim The aim was to study characteristics of induced AF and its modification by flecainide. Methods The study group consisted on 3 horses with spontaneous persistent AF and 13 with pace-induced AF. Seven horses were treated with saline (control) and eight with flecainide (2 mg/kg). ECGs were analysed using spatiotemporal cancellation of QRST complexes and calculation of AFR from the residual atrial signal. Results At AF onset, AFR was 295 ± 52 fibrillations per minute (fpm) in the horses with induced AF treated with flecainide, 269 ± 36 fpm in the control group (ns), and 364 ± 26 fpm in the horses with spontaneous persistent AF (P < 0.05 compared to the control group). Flecainide caused a decrease in AFR in all animals and restored sinus rhythm in the animals with induced AF. In the control animals, AFR increased from 269 ± 36 fpm to a plateau of 313 ± 14 fpm before decreasing to 288 ± 28 fpm during the last 10% of the AF episodes preceding spontaneous conversion (P < 0.05). Conclusion AFR in horses with induced AF resembles AFR in humans with paroxysmal AF. Flecainide caused a rapid decrease in AFR in all horses, further supporting the method to be a non-invasive technique to study the effect of antiarrhythmic compounds.

KW - Antiarrhythmic drug

KW - Atrial electrophysiology

KW - Atrial fibrillation

KW - Atrial fibrillatory rate

KW - Animal model

KW - Equine

KW - Flecainide

KW - Horse

KW - Programmed electrical stimulation

U2 - 10.1186/s12872-017-0720-1

DO - 10.1186/s12872-017-0720-1

M3 - Journal article

C2 - 29221440

VL - 17

JO - B M C Cardiovascular Disorders

JF - B M C Cardiovascular Disorders

SN - 1471-2261

M1 - 289

ER -

ID: 187261272