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Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. / Brandão, Bruna B; Madsen, Søren; Rabiee, Atefeh; Oliverio, Matteo; Ruiz, Gabriel P; Ferrucci, Danilo L; Branquinho, Jéssica L; Razolli, Daniela; Pinto, Silas; Nielsen, Thomas S; Festuccia, William T; Martins, Adriano S; Guerra, Beatriz A; Knittel, Thiago L; Søgaard, Ditte; Larsen, Steen; Helge, Jørn W; Brandauer, Josef; Velloso, Lício A; Emanuelli, Brice; Kornfeld, Jan-Wilhelm; Kahn, C Ronald; Vienberg, Sara G; Zierath, Juleen R; Treebak, Jonas T; Mori, Marcelo A.
I:
Proceedings of the National Academy of Sciences of the United States of America, Bind 117, Nr. 38, 2020, s. 23932-23941.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Brandão, BB, Madsen, S, Rabiee, A, Oliverio, M, Ruiz, GP, Ferrucci, DL, Branquinho, JL, Razolli, D, Pinto, S
, Nielsen, TS, Festuccia, WT, Martins, AS, Guerra, BA, Knittel, TL, Søgaard, D
, Larsen, S, Helge, JW, Brandauer, J, Velloso, LA
, Emanuelli, B, Kornfeld, J-W, Kahn, CR, Vienberg, SG
, Zierath, JR, Treebak, JT & Mori, MA 2020, '
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise',
Proceedings of the National Academy of Sciences of the United States of America, bind 117, nr. 38, s. 23932-23941.
https://doi.org/10.1073/pnas.2011243117APA
Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S.
, Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D.
, Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., ... Mori, M. A. (2020).
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Proceedings of the National Academy of Sciences of the United States of America,
117(38), 23932-23941.
https://doi.org/10.1073/pnas.2011243117Vancouver
Brandão BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL o.a.
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Proceedings of the National Academy of Sciences of the United States of America. 2020;117(38):23932-23941.
https://doi.org/10.1073/pnas.2011243117Author
Brandão, Bruna B ; Madsen, Søren ; Rabiee, Atefeh ; Oliverio, Matteo ; Ruiz, Gabriel P ; Ferrucci, Danilo L ; Branquinho, Jéssica L ; Razolli, Daniela ; Pinto, Silas ; Nielsen, Thomas S ; Festuccia, William T ; Martins, Adriano S ; Guerra, Beatriz A ; Knittel, Thiago L ; Søgaard, Ditte ; Larsen, Steen ; Helge, Jørn W ; Brandauer, Josef ; Velloso, Lício A ; Emanuelli, Brice ; Kornfeld, Jan-Wilhelm ; Kahn, C Ronald ; Vienberg, Sara G ; Zierath, Juleen R ; Treebak, Jonas T ; Mori, Marcelo A. / Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. I: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Bind 117, Nr. 38. s. 23932-23941.
Bibtex
@article{7d4a0e04483b49c9b1179a2afc7c3a01,
title = "Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise",
abstract = "DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.",
author = "Brand{\~a}o, {Bruna B} and S{\o}ren Madsen and Atefeh Rabiee and Matteo Oliverio and Ruiz, {Gabriel P} and Ferrucci, {Danilo L} and Branquinho, {J{\'e}ssica L} and Daniela Razolli and Silas Pinto and Nielsen, {Thomas S} and Festuccia, {William T} and Martins, {Adriano S} and Guerra, {Beatriz A} and Knittel, {Thiago L} and Ditte S{\o}gaard and Steen Larsen and Helge, {J{\o}rn W} and Josef Brandauer and Velloso, {L{\'i}cio A} and Brice Emanuelli and Jan-Wilhelm Kornfeld and Kahn, {C Ronald} and Vienberg, {Sara G} and Zierath, {Juleen R} and Treebak, {Jonas T} and Mori, {Marcelo A}",
year = "2020",
doi = "10.1073/pnas.2011243117",
language = "English",
volume = "117",
pages = "23932--23941",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "38",
}
RIS
TY - JOUR
T1 - Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise
AU - Brandão, Bruna B
AU - Madsen, Søren
AU - Rabiee, Atefeh
AU - Oliverio, Matteo
AU - Ruiz, Gabriel P
AU - Ferrucci, Danilo L
AU - Branquinho, Jéssica L
AU - Razolli, Daniela
AU - Pinto, Silas
AU - Nielsen, Thomas S
AU - Festuccia, William T
AU - Martins, Adriano S
AU - Guerra, Beatriz A
AU - Knittel, Thiago L
AU - Søgaard, Ditte
AU - Larsen, Steen
AU - Helge, Jørn W
AU - Brandauer, Josef
AU - Velloso, Lício A
AU - Emanuelli, Brice
AU - Kornfeld, Jan-Wilhelm
AU - Kahn, C Ronald
AU - Vienberg, Sara G
AU - Zierath, Juleen R
AU - Treebak, Jonas T
AU - Mori, Marcelo A
PY - 2020
Y1 - 2020
N2 - DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.
AB - DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.
U2 - 10.1073/pnas.2011243117
DO - 10.1073/pnas.2011243117
M3 - Journal article
C2 - 32900951
VL - 117
SP - 23932
EP - 23941
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 38
ER -
