Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. / Brandão, Bruna B; Madsen, Søren; Rabiee, Atefeh; Oliverio, Matteo; Ruiz, Gabriel P; Ferrucci, Danilo L; Branquinho, Jéssica L; Razolli, Daniela; Pinto, Silas; Nielsen, Thomas S; Festuccia, William T; Martins, Adriano S; Guerra, Beatriz A; Knittel, Thiago L; Søgaard, Ditte; Larsen, Steen; Helge, Jørn W; Brandauer, Josef; Velloso, Lício A; Emanuelli, Brice; Kornfeld, Jan-Wilhelm; Kahn, C Ronald; Vienberg, Sara G; Zierath, Juleen R; Treebak, Jonas T; Mori, Marcelo A.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 117, Nr. 38, 2020, s. 23932-23941.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Brandão, BB, Madsen, S, Rabiee, A, Oliverio, M, Ruiz, GP, Ferrucci, DL, Branquinho, JL, Razolli, D, Pinto, S, Nielsen, TS, Festuccia, WT, Martins, AS, Guerra, BA, Knittel, TL, Søgaard, D, Larsen, S, Helge, JW, Brandauer, J, Velloso, LA, Emanuelli, B, Kornfeld, J-W, Kahn, CR, Vienberg, SG, Zierath, JR, Treebak, JT & Mori, MA 2020, 'Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise', Proceedings of the National Academy of Sciences of the United States of America, bind 117, nr. 38, s. 23932-23941. https://doi.org/10.1073/pnas.2011243117

APA

Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., ... Mori, M. A. (2020). Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23932-23941. https://doi.org/10.1073/pnas.2011243117

Vancouver

Brandão BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL o.a. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(38):23932-23941. https://doi.org/10.1073/pnas.2011243117

Author

Brandão, Bruna B ; Madsen, Søren ; Rabiee, Atefeh ; Oliverio, Matteo ; Ruiz, Gabriel P ; Ferrucci, Danilo L ; Branquinho, Jéssica L ; Razolli, Daniela ; Pinto, Silas ; Nielsen, Thomas S ; Festuccia, William T ; Martins, Adriano S ; Guerra, Beatriz A ; Knittel, Thiago L ; Søgaard, Ditte ; Larsen, Steen ; Helge, Jørn W ; Brandauer, Josef ; Velloso, Lício A ; Emanuelli, Brice ; Kornfeld, Jan-Wilhelm ; Kahn, C Ronald ; Vienberg, Sara G ; Zierath, Juleen R ; Treebak, Jonas T ; Mori, Marcelo A. / Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. I: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Bind 117, Nr. 38. s. 23932-23941.

Bibtex

@article{7d4a0e04483b49c9b1179a2afc7c3a01,
title = "Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise",
abstract = "DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.",
author = "Brand{\~a}o, {Bruna B} and S{\o}ren Madsen and Atefeh Rabiee and Matteo Oliverio and Ruiz, {Gabriel P} and Ferrucci, {Danilo L} and Branquinho, {J{\'e}ssica L} and Daniela Razolli and Silas Pinto and Nielsen, {Thomas S} and Festuccia, {William T} and Martins, {Adriano S} and Guerra, {Beatriz A} and Knittel, {Thiago L} and Ditte S{\o}gaard and Steen Larsen and Helge, {J{\o}rn W} and Josef Brandauer and Velloso, {L{\'i}cio A} and Brice Emanuelli and Jan-Wilhelm Kornfeld and Kahn, {C Ronald} and Vienberg, {Sara G} and Zierath, {Juleen R} and Treebak, {Jonas T} and Mori, {Marcelo A}",
year = "2020",
doi = "10.1073/pnas.2011243117",
language = "English",
volume = "117",
pages = "23932--23941",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "38",

}

RIS

TY - JOUR

T1 - Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

AU - Brandão, Bruna B

AU - Madsen, Søren

AU - Rabiee, Atefeh

AU - Oliverio, Matteo

AU - Ruiz, Gabriel P

AU - Ferrucci, Danilo L

AU - Branquinho, Jéssica L

AU - Razolli, Daniela

AU - Pinto, Silas

AU - Nielsen, Thomas S

AU - Festuccia, William T

AU - Martins, Adriano S

AU - Guerra, Beatriz A

AU - Knittel, Thiago L

AU - Søgaard, Ditte

AU - Larsen, Steen

AU - Helge, Jørn W

AU - Brandauer, Josef

AU - Velloso, Lício A

AU - Emanuelli, Brice

AU - Kornfeld, Jan-Wilhelm

AU - Kahn, C Ronald

AU - Vienberg, Sara G

AU - Zierath, Juleen R

AU - Treebak, Jonas T

AU - Mori, Marcelo A

PY - 2020

Y1 - 2020

N2 - DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.

AB - DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.

U2 - 10.1073/pnas.2011243117

DO - 10.1073/pnas.2011243117

M3 - Journal article

C2 - 32900951

VL - 117

SP - 23932

EP - 23941

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 38

ER -

ID: 248456875