Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study

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Dose painting based on tumor uptake of Cu-ATSM and FDG : a comparative study. / Clausen, Malene Martini; Hansen, Anders Elias; Lundemann, Michael; Hollensen, Christian; Pommer, Tobias; Munck af Rosenschöld, Per; Kristensen, Annemarie Thuri; Kjær, Andreas; McEvoy, Fintan; Engelholm, Svend Aage.

I: Radiation Oncology, Bind 9, 228, 2014.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Clausen, MM, Hansen, AE, Lundemann, M, Hollensen, C, Pommer, T, Munck af Rosenschöld, P, Kristensen, AT, Kjær, A, McEvoy, F & Engelholm, SA 2014, 'Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study', Radiation Oncology, bind 9, 228. https://doi.org/10.1186/s13014-014-0228-0

APA

Clausen, M. M., Hansen, A. E., Lundemann, M., Hollensen, C., Pommer, T., Munck af Rosenschöld, P., ... Engelholm, S. A. (2014). Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study. Radiation Oncology, 9, [228]. https://doi.org/10.1186/s13014-014-0228-0

Vancouver

Clausen MM, Hansen AE, Lundemann M, Hollensen C, Pommer T, Munck af Rosenschöld P o.a. Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study. Radiation Oncology. 2014;9. 228. https://doi.org/10.1186/s13014-014-0228-0

Author

Clausen, Malene Martini ; Hansen, Anders Elias ; Lundemann, Michael ; Hollensen, Christian ; Pommer, Tobias ; Munck af Rosenschöld, Per ; Kristensen, Annemarie Thuri ; Kjær, Andreas ; McEvoy, Fintan ; Engelholm, Svend Aage. / Dose painting based on tumor uptake of Cu-ATSM and FDG : a comparative study. I: Radiation Oncology. 2014 ; Bind 9.

Bibtex

@article{f92f6f0161e84d6a936cd417a3e7e90d,
title = "Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study",
abstract = "BackgroundHypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[18¿F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N4)-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.MethodsPositron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and 64Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed in each sub-volume. Volumetric modulated arc therapy plans were optimized based on the dose escalation regions for each scan for a total of three dose plans for each dog. The prescription dose for the GTV was 45 Gy (100{\%}) and it was linearly escalated to a maximum of 150{\%}. The correlations between dose painting plans were analyzed with construction of dose distribution density maps and quality volume histograms (QVH). Correlation between high-dose regions was investigated with Dice correlation coefficients.ResultsComparison of dose plans revealed varying degree of correlation between cases. Some cases displayed a separation of high-dose regions in the comparison of FDG vs. 64Cu-ATSM dose plans at both time points. Among the Dice correlation coefficients, the high dose regions showed the lowest degree of agreement, indicating potential benefit of using multiple tracers for dose painting. QVH analysis revealed that FDG-based dose painting plans adequately covered approximately 50{\%} of the hypoxic regions.ConclusionRadiotherapy plans optimized with the current approach for cut-off values and dose region definitions based on FDG, 64Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that 64Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting strategy in radiotherapy treatment planning.",
author = "Clausen, {Malene Martini} and Hansen, {Anders Elias} and Michael Lundemann and Christian Hollensen and Tobias Pommer and {Munck af Rosensch{\"o}ld}, Per and Kristensen, {Annemarie Thuri} and Andreas Kj{\ae}r and Fintan McEvoy and Engelholm, {Svend Aage}",
year = "2014",
doi = "10.1186/s13014-014-0228-0",
language = "English",
volume = "9",
journal = "Radiation Oncology",
issn = "1748-717X",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Dose painting based on tumor uptake of Cu-ATSM and FDG

T2 - a comparative study

AU - Clausen, Malene Martini

AU - Hansen, Anders Elias

AU - Lundemann, Michael

AU - Hollensen, Christian

AU - Pommer, Tobias

AU - Munck af Rosenschöld, Per

AU - Kristensen, Annemarie Thuri

AU - Kjær, Andreas

AU - McEvoy, Fintan

AU - Engelholm, Svend Aage

PY - 2014

Y1 - 2014

N2 - BackgroundHypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[18¿F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N4)-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.MethodsPositron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and 64Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed in each sub-volume. Volumetric modulated arc therapy plans were optimized based on the dose escalation regions for each scan for a total of three dose plans for each dog. The prescription dose for the GTV was 45 Gy (100%) and it was linearly escalated to a maximum of 150%. The correlations between dose painting plans were analyzed with construction of dose distribution density maps and quality volume histograms (QVH). Correlation between high-dose regions was investigated with Dice correlation coefficients.ResultsComparison of dose plans revealed varying degree of correlation between cases. Some cases displayed a separation of high-dose regions in the comparison of FDG vs. 64Cu-ATSM dose plans at both time points. Among the Dice correlation coefficients, the high dose regions showed the lowest degree of agreement, indicating potential benefit of using multiple tracers for dose painting. QVH analysis revealed that FDG-based dose painting plans adequately covered approximately 50% of the hypoxic regions.ConclusionRadiotherapy plans optimized with the current approach for cut-off values and dose region definitions based on FDG, 64Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that 64Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting strategy in radiotherapy treatment planning.

AB - BackgroundHypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[18¿F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N4)-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.MethodsPositron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and 64Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed in each sub-volume. Volumetric modulated arc therapy plans were optimized based on the dose escalation regions for each scan for a total of three dose plans for each dog. The prescription dose for the GTV was 45 Gy (100%) and it was linearly escalated to a maximum of 150%. The correlations between dose painting plans were analyzed with construction of dose distribution density maps and quality volume histograms (QVH). Correlation between high-dose regions was investigated with Dice correlation coefficients.ResultsComparison of dose plans revealed varying degree of correlation between cases. Some cases displayed a separation of high-dose regions in the comparison of FDG vs. 64Cu-ATSM dose plans at both time points. Among the Dice correlation coefficients, the high dose regions showed the lowest degree of agreement, indicating potential benefit of using multiple tracers for dose painting. QVH analysis revealed that FDG-based dose painting plans adequately covered approximately 50% of the hypoxic regions.ConclusionRadiotherapy plans optimized with the current approach for cut-off values and dose region definitions based on FDG, 64Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that 64Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting strategy in radiotherapy treatment planning.

U2 - 10.1186/s13014-014-0228-0

DO - 10.1186/s13014-014-0228-0

M3 - Journal article

VL - 9

JO - Radiation Oncology

JF - Radiation Oncology

SN - 1748-717X

M1 - 228

ER -

ID: 131361093