Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men

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Standard

Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. / Auerbach, Pernille; Nordby, Pernille; Bendtsen, Line Quist; Mehlsen, Jesper Loekke; Basnet, Smita Kunwar; Vestergaard, Henrik; Ploug, Thorkil; Stallknecht, Bente Merete.

I: A J P: Regulatory, Integrative and Comparative Physiology (Online), Bind 305, 01.09.2013, s. R490-498.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Auerbach, P, Nordby, P, Bendtsen, LQ, Mehlsen, JL, Basnet, SK, Vestergaard, H, Ploug, T & Stallknecht, BM 2013, 'Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men', A J P: Regulatory, Integrative and Comparative Physiology (Online), bind 305, s. R490-498. https://doi.org/10.1152/ajpregu.00575.2012

APA

Auerbach, P., Nordby, P., Bendtsen, L. Q., Mehlsen, J. L., Basnet, S. K., Vestergaard, H., Ploug, T., & Stallknecht, B. M. (2013). Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. A J P: Regulatory, Integrative and Comparative Physiology (Online), 305, R490-498. https://doi.org/10.1152/ajpregu.00575.2012

Vancouver

Auerbach P, Nordby P, Bendtsen LQ, Mehlsen JL, Basnet SK, Vestergaard H o.a. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. A J P: Regulatory, Integrative and Comparative Physiology (Online). 2013 sep. 1;305:R490-498. https://doi.org/10.1152/ajpregu.00575.2012

Author

Auerbach, Pernille ; Nordby, Pernille ; Bendtsen, Line Quist ; Mehlsen, Jesper Loekke ; Basnet, Smita Kunwar ; Vestergaard, Henrik ; Ploug, Thorkil ; Stallknecht, Bente Merete. / Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. I: A J P: Regulatory, Integrative and Comparative Physiology (Online). 2013 ; Bind 305. s. R490-498.

Bibtex

@article{7b2d3c0bf06543c0a4eb75a216ab210c,
title = "Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men",
abstract = "Obese individuals are characterized by low circulating adiponectin concentrations and an increased number of macrophages in adipose tissue, which is believed to be causally associated with chronic low-grade inflammation and insulin resistance. Regular physical exercise decreases overall morbidity in obese subjects which may be due to modulations of inflammatory pathways. In this randomized clinical trial we investigated the separate effects of endurance training-induced weight loss, diet-induced weight loss and endurance training per se (without weight loss) on plasma adiponectin multimer composition (Western blotting) and adipose tissue macrophage content (immunohistochemistry) in young, moderately overweight men. Weight loss and endurance training per se decreased whole body fat percentage in an additive manner. No intervention-induced changes were observed for plasma total adiponectin. Surprisingly, endurance training, irrespectively of any associated weight loss, shifted the adiponectin multimer distribution towards a lower molecular weight (21% decrease in HMW/LMW, P=0.015) whereas diet-induced weight loss shifted the distribution towards a higher molecular weight (42% increase in HMW/MMW, P<0.001). Furthermore, endurance training per se increased the number of anti-inflammatory CD163+ macrophages (from 12.7 [2.1] (mean [SE]) to 16.1 [3.1] CD163+ cells/100 adipocytes, P=0.013), whereas diet-induced weight loss tended to decrease CD68+ macrophages in subcutaneous abdominal adipose tissue. Thus, regular physical exercise influences systemic and adipose tissue inflammatory pathways differently than diet-induced weight loss in younger, moderately overweight men. Our data suggest that some of the health benefits of a physically active lifestyle may occur through modulations of anti- rather than pro-inflammatory pathways in young, overweight men.",
author = "Pernille Auerbach and Pernille Nordby and Bendtsen, {Line Quist} and Mehlsen, {Jesper Loekke} and Basnet, {Smita Kunwar} and Henrik Vestergaard and Thorkil Ploug and Stallknecht, {Bente Merete}",
year = "2013",
month = sep,
day = "1",
doi = "10.1152/ajpregu.00575.2012",
language = "English",
volume = "305",
pages = "R490--498",
journal = "A J P: Regulatory, Integrative and Comparative Physiology (Online)",
issn = "1522-1490",
publisher = "American Physiological Society",

}

RIS

TY - JOUR

T1 - Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men

AU - Auerbach, Pernille

AU - Nordby, Pernille

AU - Bendtsen, Line Quist

AU - Mehlsen, Jesper Loekke

AU - Basnet, Smita Kunwar

AU - Vestergaard, Henrik

AU - Ploug, Thorkil

AU - Stallknecht, Bente Merete

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Obese individuals are characterized by low circulating adiponectin concentrations and an increased number of macrophages in adipose tissue, which is believed to be causally associated with chronic low-grade inflammation and insulin resistance. Regular physical exercise decreases overall morbidity in obese subjects which may be due to modulations of inflammatory pathways. In this randomized clinical trial we investigated the separate effects of endurance training-induced weight loss, diet-induced weight loss and endurance training per se (without weight loss) on plasma adiponectin multimer composition (Western blotting) and adipose tissue macrophage content (immunohistochemistry) in young, moderately overweight men. Weight loss and endurance training per se decreased whole body fat percentage in an additive manner. No intervention-induced changes were observed for plasma total adiponectin. Surprisingly, endurance training, irrespectively of any associated weight loss, shifted the adiponectin multimer distribution towards a lower molecular weight (21% decrease in HMW/LMW, P=0.015) whereas diet-induced weight loss shifted the distribution towards a higher molecular weight (42% increase in HMW/MMW, P<0.001). Furthermore, endurance training per se increased the number of anti-inflammatory CD163+ macrophages (from 12.7 [2.1] (mean [SE]) to 16.1 [3.1] CD163+ cells/100 adipocytes, P=0.013), whereas diet-induced weight loss tended to decrease CD68+ macrophages in subcutaneous abdominal adipose tissue. Thus, regular physical exercise influences systemic and adipose tissue inflammatory pathways differently than diet-induced weight loss in younger, moderately overweight men. Our data suggest that some of the health benefits of a physically active lifestyle may occur through modulations of anti- rather than pro-inflammatory pathways in young, overweight men.

AB - Obese individuals are characterized by low circulating adiponectin concentrations and an increased number of macrophages in adipose tissue, which is believed to be causally associated with chronic low-grade inflammation and insulin resistance. Regular physical exercise decreases overall morbidity in obese subjects which may be due to modulations of inflammatory pathways. In this randomized clinical trial we investigated the separate effects of endurance training-induced weight loss, diet-induced weight loss and endurance training per se (without weight loss) on plasma adiponectin multimer composition (Western blotting) and adipose tissue macrophage content (immunohistochemistry) in young, moderately overweight men. Weight loss and endurance training per se decreased whole body fat percentage in an additive manner. No intervention-induced changes were observed for plasma total adiponectin. Surprisingly, endurance training, irrespectively of any associated weight loss, shifted the adiponectin multimer distribution towards a lower molecular weight (21% decrease in HMW/LMW, P=0.015) whereas diet-induced weight loss shifted the distribution towards a higher molecular weight (42% increase in HMW/MMW, P<0.001). Furthermore, endurance training per se increased the number of anti-inflammatory CD163+ macrophages (from 12.7 [2.1] (mean [SE]) to 16.1 [3.1] CD163+ cells/100 adipocytes, P=0.013), whereas diet-induced weight loss tended to decrease CD68+ macrophages in subcutaneous abdominal adipose tissue. Thus, regular physical exercise influences systemic and adipose tissue inflammatory pathways differently than diet-induced weight loss in younger, moderately overweight men. Our data suggest that some of the health benefits of a physically active lifestyle may occur through modulations of anti- rather than pro-inflammatory pathways in young, overweight men.

U2 - 10.1152/ajpregu.00575.2012

DO - 10.1152/ajpregu.00575.2012

M3 - Journal article

C2 - 23842679

VL - 305

SP - R490-498

JO - A J P: Regulatory, Integrative and Comparative Physiology (Online)

JF - A J P: Regulatory, Integrative and Comparative Physiology (Online)

SN - 1522-1490

ER -

ID: 48867120