Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
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Dokumenter
- OA-Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
Forlagets udgivne version, 563 KB, PDF-dokument
Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.
Originalsprog | Engelsk |
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Artikelnummer | 727 |
Tidsskrift | Frontiers in Physiology |
Vol/bind | 11 |
Antal sider | 12 |
ISSN | 1664-042X |
DOI | |
Status | Udgivet - 2020 |
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