Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5 : a prospective cohort study. / Sorensen, Ida M. H.; Bjergfelt, Sasha S.; Hjortkjær, Henrik O.; Kofoed, Klaus F.; Lange, Theis; Feldt-Rasmussen, Bo; Christoffersen, Christina; Bro, Susanne.

I: Nephrology Dialysis Transplantation, Bind 38, Nr. 5, 2023, s. 1227–1239.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Sorensen, IMH, Bjergfelt, SS, Hjortkjær, HO, Kofoed, KF, Lange, T, Feldt-Rasmussen, B, Christoffersen, C & Bro, S 2023, 'Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study', Nephrology Dialysis Transplantation, bind 38, nr. 5, s. 1227–1239. https://doi.org/10.1093/ndt/gfac252

APA

Sorensen, I. M. H., Bjergfelt, S. S., Hjortkjær, H. O., Kofoed, K. F., Lange, T., Feldt-Rasmussen, B., Christoffersen, C., & Bro, S. (2023). Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study. Nephrology Dialysis Transplantation, 38(5), 1227–1239. https://doi.org/10.1093/ndt/gfac252

Vancouver

Sorensen IMH, Bjergfelt SS, Hjortkjær HO, Kofoed KF, Lange T, Feldt-Rasmussen B o.a. Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study. Nephrology Dialysis Transplantation. 2023;38(5):1227–1239. https://doi.org/10.1093/ndt/gfac252

Author

Sorensen, Ida M. H. ; Bjergfelt, Sasha S. ; Hjortkjær, Henrik O. ; Kofoed, Klaus F. ; Lange, Theis ; Feldt-Rasmussen, Bo ; Christoffersen, Christina ; Bro, Susanne. / Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5 : a prospective cohort study. I: Nephrology Dialysis Transplantation. 2023 ; Bind 38, Nr. 5. s. 1227–1239.

Bibtex

@article{043050c305524b6baa0b0269f18363d6,
title = "Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5: a prospective cohort study",
abstract = "Background Vascular calcification is a known risk factor for cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, since there is a lack of studies examining several arterial regions at a time, we aimed to evaluate the risk of major adverse cardiovascular events (MACE) and all-cause mortality according to calcium scores in five major arterial sites. Methods This was a prospective study of 580 patients from the Copenhagen CKD Cohort. Multidetector computed tomography of the coronary and carotid arteries, the thoracic aorta, the abdominal aorta and the iliac arteries was used to determine vascular calcification at baseline. Calcium scores were divided into categories: 0, 1-100, 101-400 and >400. Results During the follow-up period of 4.1 years a total of 59 cardiovascular events and 64 all-cause deaths occurred. In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, hypertension, diabetes mellitus, hypercholesterolemia and smoking, only the coronary and carotid arteries, and the thoracic aorta were independent predictors of the designated endpoints. When examining the potential of calcification in the five arterial sites for predicting MACE, the difference in C-statistic was also most pronounced in these three sites, at 0.21 [95% confidence interval (CI) 0.16%-0.26%, P < .001], 0.26 (95% CI 0.22%-0.3%, P < .001) and 0.20 (95% CI 0.16%-0.24%, P < .001), respectively. This trend also applied to all-cause mortality. Conclusions The overall results, including data on specificity, suggest that calcium scores of the coronary and carotid arteries have the most potential for identifying patients with CKD at high cardiovascular risk and for evaluating new therapies.",
keywords = "calcification, cardiovascular, CKD, coronary calcification, vascular calcification, ABDOMINAL AORTIC CALCIFICATION, VASCULAR CALCIFICATION, RENAL-DISEASE, SODIUM THIOSULFATE, FOLLOW-UP, ALL-CAUSE, HEMODIALYSIS, ATHEROSCLEROSIS, RISK, PROGRESSION",
author = "Sorensen, {Ida M. H.} and Bjergfelt, {Sasha S.} and Hjortkj{\ae}r, {Henrik O.} and Kofoed, {Klaus F.} and Theis Lange and Bo Feldt-Rasmussen and Christina Christoffersen and Susanne Bro",
year = "2023",
doi = "10.1093/ndt/gfac252",
language = "English",
volume = "38",
pages = "1227–1239",
journal = "Nephrology, Dialysis, Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Coronary and extra-coronary artery calcium scores as predictors of cardiovascular events and mortality in chronic kidney disease stages 1-5

T2 - a prospective cohort study

AU - Sorensen, Ida M. H.

AU - Bjergfelt, Sasha S.

AU - Hjortkjær, Henrik O.

AU - Kofoed, Klaus F.

AU - Lange, Theis

AU - Feldt-Rasmussen, Bo

AU - Christoffersen, Christina

AU - Bro, Susanne

PY - 2023

Y1 - 2023

N2 - Background Vascular calcification is a known risk factor for cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, since there is a lack of studies examining several arterial regions at a time, we aimed to evaluate the risk of major adverse cardiovascular events (MACE) and all-cause mortality according to calcium scores in five major arterial sites. Methods This was a prospective study of 580 patients from the Copenhagen CKD Cohort. Multidetector computed tomography of the coronary and carotid arteries, the thoracic aorta, the abdominal aorta and the iliac arteries was used to determine vascular calcification at baseline. Calcium scores were divided into categories: 0, 1-100, 101-400 and >400. Results During the follow-up period of 4.1 years a total of 59 cardiovascular events and 64 all-cause deaths occurred. In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, hypertension, diabetes mellitus, hypercholesterolemia and smoking, only the coronary and carotid arteries, and the thoracic aorta were independent predictors of the designated endpoints. When examining the potential of calcification in the five arterial sites for predicting MACE, the difference in C-statistic was also most pronounced in these three sites, at 0.21 [95% confidence interval (CI) 0.16%-0.26%, P < .001], 0.26 (95% CI 0.22%-0.3%, P < .001) and 0.20 (95% CI 0.16%-0.24%, P < .001), respectively. This trend also applied to all-cause mortality. Conclusions The overall results, including data on specificity, suggest that calcium scores of the coronary and carotid arteries have the most potential for identifying patients with CKD at high cardiovascular risk and for evaluating new therapies.

AB - Background Vascular calcification is a known risk factor for cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, since there is a lack of studies examining several arterial regions at a time, we aimed to evaluate the risk of major adverse cardiovascular events (MACE) and all-cause mortality according to calcium scores in five major arterial sites. Methods This was a prospective study of 580 patients from the Copenhagen CKD Cohort. Multidetector computed tomography of the coronary and carotid arteries, the thoracic aorta, the abdominal aorta and the iliac arteries was used to determine vascular calcification at baseline. Calcium scores were divided into categories: 0, 1-100, 101-400 and >400. Results During the follow-up period of 4.1 years a total of 59 cardiovascular events and 64 all-cause deaths occurred. In Cox proportional hazards models adjusted for age, sex, estimated glomerular filtration rate, hypertension, diabetes mellitus, hypercholesterolemia and smoking, only the coronary and carotid arteries, and the thoracic aorta were independent predictors of the designated endpoints. When examining the potential of calcification in the five arterial sites for predicting MACE, the difference in C-statistic was also most pronounced in these three sites, at 0.21 [95% confidence interval (CI) 0.16%-0.26%, P < .001], 0.26 (95% CI 0.22%-0.3%, P < .001) and 0.20 (95% CI 0.16%-0.24%, P < .001), respectively. This trend also applied to all-cause mortality. Conclusions The overall results, including data on specificity, suggest that calcium scores of the coronary and carotid arteries have the most potential for identifying patients with CKD at high cardiovascular risk and for evaluating new therapies.

KW - calcification

KW - cardiovascular

KW - CKD

KW - coronary calcification

KW - vascular calcification

KW - ABDOMINAL AORTIC CALCIFICATION

KW - VASCULAR CALCIFICATION

KW - RENAL-DISEASE

KW - SODIUM THIOSULFATE

KW - FOLLOW-UP

KW - ALL-CAUSE

KW - HEMODIALYSIS

KW - ATHEROSCLEROSIS

KW - RISK

KW - PROGRESSION

U2 - 10.1093/ndt/gfac252

DO - 10.1093/ndt/gfac252

M3 - Journal article

C2 - 36066908

VL - 38

SP - 1227

EP - 1239

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

SN - 0931-0509

IS - 5

ER -

ID: 321254001