Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance.

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Standard

Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance. / Skov-Jensen, Camilla; Skovbro, Mette; Flint, Anne; Helge, Jørn Wulff; Dela, Flemming.

I: Applied Physiology, Nutrition and Metabolism, Bind 32, Nr. 1, 2007, s. 115-24.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Skov-Jensen, C, Skovbro, M, Flint, A, Helge, JW & Dela, F 2007, 'Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance.', Applied Physiology, Nutrition and Metabolism, bind 32, nr. 1, s. 115-24. https://doi.org/10.1139/h06-098

APA

Skov-Jensen, C., Skovbro, M., Flint, A., Helge, J. W., & Dela, F. (2007). Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance. Applied Physiology, Nutrition and Metabolism, 32(1), 115-24. https://doi.org/10.1139/h06-098

Vancouver

Skov-Jensen C, Skovbro M, Flint A, Helge JW, Dela F. Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance. Applied Physiology, Nutrition and Metabolism. 2007;32(1):115-24. https://doi.org/10.1139/h06-098

Author

Skov-Jensen, Camilla ; Skovbro, Mette ; Flint, Anne ; Helge, Jørn Wulff ; Dela, Flemming. / Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance. I: Applied Physiology, Nutrition and Metabolism. 2007 ; Bind 32, Nr. 1. s. 115-24.

Bibtex

@article{6be29d10ab5b11ddb5e9000ea68e967b,
title = "Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance.",
abstract = "Exercise superimposed on insulin stimulation is shown to increase muscle glucose metabolism and these two stimuli have synergistic effects. The objective of this study was to investigate glucose infusion rates (GIR) in groups with a wide variation in terms of insulin sensitivity during insulin stimulation alone and with superimposed exercise. Patients with type 2 diabetes, subjects with impaired glucose tolerance (IGT), healthy controls, and endurance-trained subjects were studied. The groups were matched for age and lean body mass (LBM), and differed in peak oxygen uptake (VO2 peak), body fat percentage, body mass index (BMI), fasting plasma glucose concentration, and oral glucose-tolerance test (OGTT). Each subject underwent a two-step sequential hyperinsulinemic, euglycemic clamp. During the last 30 min of the 2nd clamp step, subjects exercised on a bicycle at 43{\%} +/- 2{\%} of VO2 peak. In agreement with the OGTT data, the presence of different GIR during insulin stimulation alone demonstrated varying levels of insulin sensitivity between groups. However, the impairment of GIR in IGT observed during insulin stimulation alone was abolished compared to controls when exercise was superimposed on insulin stimulation. Humans with IGT are resistant to insulin-stimulated but not to exercise-induced glucose uptake.",
author = "Camilla Skov-Jensen and Mette Skovbro and Anne Flint and Helge, {J{\o}rn Wulff} and Flemming Dela",
note = "Keywords: Analysis of Variance; Biopsy; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Exercise; Exercise Test; Glucose; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin; Lipids; Male; Middle Aged; Muscle Contraction; Muscle, Skeletal; Oxygen; Reference Values; Time Factors",
year = "2007",
doi = "10.1139/h06-098",
language = "English",
volume = "32",
pages = "115--24",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "Canadian Science Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance.

AU - Skov-Jensen, Camilla

AU - Skovbro, Mette

AU - Flint, Anne

AU - Helge, Jørn Wulff

AU - Dela, Flemming

N1 - Keywords: Analysis of Variance; Biopsy; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Exercise; Exercise Test; Glucose; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin; Lipids; Male; Middle Aged; Muscle Contraction; Muscle, Skeletal; Oxygen; Reference Values; Time Factors

PY - 2007

Y1 - 2007

N2 - Exercise superimposed on insulin stimulation is shown to increase muscle glucose metabolism and these two stimuli have synergistic effects. The objective of this study was to investigate glucose infusion rates (GIR) in groups with a wide variation in terms of insulin sensitivity during insulin stimulation alone and with superimposed exercise. Patients with type 2 diabetes, subjects with impaired glucose tolerance (IGT), healthy controls, and endurance-trained subjects were studied. The groups were matched for age and lean body mass (LBM), and differed in peak oxygen uptake (VO2 peak), body fat percentage, body mass index (BMI), fasting plasma glucose concentration, and oral glucose-tolerance test (OGTT). Each subject underwent a two-step sequential hyperinsulinemic, euglycemic clamp. During the last 30 min of the 2nd clamp step, subjects exercised on a bicycle at 43% +/- 2% of VO2 peak. In agreement with the OGTT data, the presence of different GIR during insulin stimulation alone demonstrated varying levels of insulin sensitivity between groups. However, the impairment of GIR in IGT observed during insulin stimulation alone was abolished compared to controls when exercise was superimposed on insulin stimulation. Humans with IGT are resistant to insulin-stimulated but not to exercise-induced glucose uptake.

AB - Exercise superimposed on insulin stimulation is shown to increase muscle glucose metabolism and these two stimuli have synergistic effects. The objective of this study was to investigate glucose infusion rates (GIR) in groups with a wide variation in terms of insulin sensitivity during insulin stimulation alone and with superimposed exercise. Patients with type 2 diabetes, subjects with impaired glucose tolerance (IGT), healthy controls, and endurance-trained subjects were studied. The groups were matched for age and lean body mass (LBM), and differed in peak oxygen uptake (VO2 peak), body fat percentage, body mass index (BMI), fasting plasma glucose concentration, and oral glucose-tolerance test (OGTT). Each subject underwent a two-step sequential hyperinsulinemic, euglycemic clamp. During the last 30 min of the 2nd clamp step, subjects exercised on a bicycle at 43% +/- 2% of VO2 peak. In agreement with the OGTT data, the presence of different GIR during insulin stimulation alone demonstrated varying levels of insulin sensitivity between groups. However, the impairment of GIR in IGT observed during insulin stimulation alone was abolished compared to controls when exercise was superimposed on insulin stimulation. Humans with IGT are resistant to insulin-stimulated but not to exercise-induced glucose uptake.

U2 - 10.1139/h06-098

DO - 10.1139/h06-098

M3 - Journal article

C2 - 17332788

VL - 32

SP - 115

EP - 124

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

IS - 1

ER -

ID: 8419485