Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges

Publikation: Bidrag til tidsskriftReview

Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle exercise adaptations across many different exercise modalities. The study of redox signaling is moving towards a growing appreciation that these ROS do not signal in a global unspecific way, but rather elicit their effects in distinct subcellular compartments. This short review will first outline the sources of ROS in exercising skeletal muscle and then discuss some examples of exercise adaptations, which are evidenced to be regulated by compartmentalized redox signaling. We speculate that knowledge of these redox pathways might one day allow targeted manipulation to increase redox-signaling in specific compartments to augment the exercise-hormetic response in health and disease.

OriginalsprogEngelsk
Artikelnummer101473
TidsskriftRedox Biology
ISSN2213-2317
DOI
StatusE-pub ahead of print - 22 feb. 2020

Bibliografisk note

CURIS 2020 NEXS 041 (Importeret 13. marts 2020). [Epub] (Open Access!)

ID: 237513881