TY - JOUR

T1 - Coenzyme Q10 Supplementation in Statin Treated Patients

T2 - A Double-Blinded Randomized Placebo-Controlled Trial

AU - Dohlmann, Tine L.

AU - Kuhlman, Anja B.

AU - Morville, Thomas

AU - Dahl, Maria

AU - Asping, Magnus

AU - Orlando, Patrick

AU - Silvestri, Sonia

AU - Tiano, Luca

AU - Helge, Jørn W.

AU - Dela, Flemming

AU - Larsen, Steen

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle and impaired mitochondrial function. Supplementation with CoQ10 focusing on levels of CoQ10 in skeletal muscle and mitochondrial function has not been investigated in patients treated with statins. To investigate whether concomitant administration of CoQ10 with statins increases the muscle CoQ10 levels and improves the mitochondrial function, and if changes in muscle CoQ10 levels correlate with changes in the intensity of myalgia. 37 men and women in simvastatin therapy with and without myalgia were randomized to receive 400 mg CoQ10 daily or matched placebo tablets for eight weeks. Muscle CoQ10 levels, mitochondrial respiratory capacity, mitochondrial content (using citrate synthase activity as a biomarker), and production of reactive oxygen species were measured before and after CoQ10 supplementation, and intensity of myalgia was determined using the 10 cm visual analogue scale. Muscle CoQ10 content and mitochondrial function were unaltered by CoQ10 supplementation. Individual changes in muscle CoQ10 levels were not correlated with changes in intensity of myalgia. CoQ10 supplementation had no effect on muscle CoQ10 levels or mitochondrial function and did not affect symptoms of myalgia.

AB - Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal muscle and impaired mitochondrial function. Supplementation with CoQ10 focusing on levels of CoQ10 in skeletal muscle and mitochondrial function has not been investigated in patients treated with statins. To investigate whether concomitant administration of CoQ10 with statins increases the muscle CoQ10 levels and improves the mitochondrial function, and if changes in muscle CoQ10 levels correlate with changes in the intensity of myalgia. 37 men and women in simvastatin therapy with and without myalgia were randomized to receive 400 mg CoQ10 daily or matched placebo tablets for eight weeks. Muscle CoQ10 levels, mitochondrial respiratory capacity, mitochondrial content (using citrate synthase activity as a biomarker), and production of reactive oxygen species were measured before and after CoQ10 supplementation, and intensity of myalgia was determined using the 10 cm visual analogue scale. Muscle CoQ10 content and mitochondrial function were unaltered by CoQ10 supplementation. Individual changes in muscle CoQ10 levels were not correlated with changes in intensity of myalgia. CoQ10 supplementation had no effect on muscle CoQ10 levels or mitochondrial function and did not affect symptoms of myalgia.

KW - antioxidant

KW - diet supplementation

KW - HMG-CoA reductase inhibitor

KW - mitochondria

KW - myopathy

KW - reactive oxygen species

KW - skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85138558835&partnerID=8YFLogxK

U2 - 10.3390/antiox11091698

DO - 10.3390/antiox11091698

M3 - Journal article

C2 - 36139772

AN - SCOPUS:85138558835

VL - 11

SP - 1

EP - 12

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 9

M1 - 1698

ER -