Chromogranin A in the mammalian heart: Expression without secretion

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Standard

Chromogranin A in the mammalian heart : Expression without secretion. / Hansen, Lasse H.; Darkner, Stine; Svendsen, Jesper H.; Henningsen, Kristoffer; Pehrson, Steen; Chen, Xu; Vakhrushev, Sergey Y.; Schjoldager, Katrine T.; Goetze, Jens P.

I: Biomarkers in Medicine, Bind 11, Nr. 7, 07.2017, s. 541-545.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Hansen, LH, Darkner, S, Svendsen, JH, Henningsen, K, Pehrson, S, Chen, X, Vakhrushev, SY, Schjoldager, KT & Goetze, JP 2017, 'Chromogranin A in the mammalian heart: Expression without secretion', Biomarkers in Medicine, bind 11, nr. 7, s. 541-545. https://doi.org/10.2217/bmm-2017-0052

APA

Hansen, L. H., Darkner, S., Svendsen, J. H., Henningsen, K., Pehrson, S., Chen, X., Vakhrushev, S. Y., Schjoldager, K. T., & Goetze, J. P. (2017). Chromogranin A in the mammalian heart: Expression without secretion. Biomarkers in Medicine, 11(7), 541-545. https://doi.org/10.2217/bmm-2017-0052

Vancouver

Hansen LH, Darkner S, Svendsen JH, Henningsen K, Pehrson S, Chen X o.a. Chromogranin A in the mammalian heart: Expression without secretion. Biomarkers in Medicine. 2017 jul.;11(7):541-545. https://doi.org/10.2217/bmm-2017-0052

Author

Hansen, Lasse H. ; Darkner, Stine ; Svendsen, Jesper H. ; Henningsen, Kristoffer ; Pehrson, Steen ; Chen, Xu ; Vakhrushev, Sergey Y. ; Schjoldager, Katrine T. ; Goetze, Jens P. / Chromogranin A in the mammalian heart : Expression without secretion. I: Biomarkers in Medicine. 2017 ; Bind 11, Nr. 7. s. 541-545.

Bibtex

@article{12215df1d7de4b24bbf5576d86ed136b,
title = "Chromogranin A in the mammalian heart: Expression without secretion",
abstract = "Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays. Results: We identified CgA-derived glycopeptides exclusively in the atrial tissue. Proatrial natriuretic peptide is secreted from the heart (coronary sinus [795 pmol/l] vs left atrium [678 pmol/l]; p < 0.01) whereas no CgA gradient across the heart could be established (p = 0.6366). Conclusion: The cardiac atria express but do not secrete CgA into circulation in patients with atrial disease.",
keywords = "atrial fibrillation, atrial natriuretic peptide, chromogranin A, heart, secretion",
author = "Hansen, {Lasse H.} and Stine Darkner and Svendsen, {Jesper H.} and Kristoffer Henningsen and Steen Pehrson and Xu Chen and Vakhrushev, {Sergey Y.} and Schjoldager, {Katrine T.} and Goetze, {Jens P.}",
year = "2017",
month = jul,
doi = "10.2217/bmm-2017-0052",
language = "English",
volume = "11",
pages = "541--545",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Chromogranin A in the mammalian heart

T2 - Expression without secretion

AU - Hansen, Lasse H.

AU - Darkner, Stine

AU - Svendsen, Jesper H.

AU - Henningsen, Kristoffer

AU - Pehrson, Steen

AU - Chen, Xu

AU - Vakhrushev, Sergey Y.

AU - Schjoldager, Katrine T.

AU - Goetze, Jens P.

PY - 2017/7

Y1 - 2017/7

N2 - Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays. Results: We identified CgA-derived glycopeptides exclusively in the atrial tissue. Proatrial natriuretic peptide is secreted from the heart (coronary sinus [795 pmol/l] vs left atrium [678 pmol/l]; p < 0.01) whereas no CgA gradient across the heart could be established (p = 0.6366). Conclusion: The cardiac atria express but do not secrete CgA into circulation in patients with atrial disease.

AB - Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays. Results: We identified CgA-derived glycopeptides exclusively in the atrial tissue. Proatrial natriuretic peptide is secreted from the heart (coronary sinus [795 pmol/l] vs left atrium [678 pmol/l]; p < 0.01) whereas no CgA gradient across the heart could be established (p = 0.6366). Conclusion: The cardiac atria express but do not secrete CgA into circulation in patients with atrial disease.

KW - atrial fibrillation

KW - atrial natriuretic peptide

KW - chromogranin A

KW - heart

KW - secretion

U2 - 10.2217/bmm-2017-0052

DO - 10.2217/bmm-2017-0052

M3 - Letter

C2 - 28685598

AN - SCOPUS:85024365840

VL - 11

SP - 541

EP - 545

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 7

ER -

ID: 184773107