Carotid baroreflex function at the onset of cycling in men
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Carotid baroreflex function at the onset of cycling in men. / Barbosa, Thales C; Vianna, Lauro C; Hashimoto, Takeshi; Petersen, Lonnie G; Olesen, Niels D; Tsukamoto, Hayato; Sørensen, Henrik ; Ogoh, Shigehiko; Nóbrega, Antonio C L; Secher, Niels H.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 311, Nr. 5, 01.11.2016, s. R870-R878.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Carotid baroreflex function at the onset of cycling in men
AU - Barbosa, Thales C
AU - Vianna, Lauro C
AU - Hashimoto, Takeshi
AU - Petersen, Lonnie G
AU - Olesen, Niels D
AU - Tsukamoto, Hayato
AU - Sørensen, Henrik
AU - Ogoh, Shigehiko
AU - Nóbrega, Antonio C L
AU - Secher, Niels H
N1 - Copyright © 2016 the American Physiological Society.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Arterial baroreflex function is important for blood pressure control during exercise, but its contribution to cardiovascular adjustments at the onset of cycling exercise remains unclear. Fifteen healthy male subjects (24 ± 1 yr) performed 45-s trials of low- and moderate-intensity cycling, with carotid baroreceptor stimulation by neck suction at -60 Torr applied 0-5, 10-15, and 30-35 s after the onset of exercise. Cardiovascular responses to neck suction during cycling were compared with those obtained at rest. An attenuated reflex decrease in heart rate following neck suction was detected during moderate-intensity exercise, compared with the response at rest (P < 0.05). Furthermore, compared with the reflex decrease in blood pressure elicited at rest, neck suction elicited an augmented decrease in blood pressure at 0-5 and 10-15 s during low-intensity exercise and in all periods during moderate-intensity exercise (P < 0.05). The reflex depressor response at the onset of cycling was primarily mediated by an increase in the total vascular conductance. These findings evidence altered carotid baroreflex function during the first 35 s of cycling compared with rest, with attenuated bradycardic response, and augmented depressor response to carotid baroreceptor stimulation.
AB - Arterial baroreflex function is important for blood pressure control during exercise, but its contribution to cardiovascular adjustments at the onset of cycling exercise remains unclear. Fifteen healthy male subjects (24 ± 1 yr) performed 45-s trials of low- and moderate-intensity cycling, with carotid baroreceptor stimulation by neck suction at -60 Torr applied 0-5, 10-15, and 30-35 s after the onset of exercise. Cardiovascular responses to neck suction during cycling were compared with those obtained at rest. An attenuated reflex decrease in heart rate following neck suction was detected during moderate-intensity exercise, compared with the response at rest (P < 0.05). Furthermore, compared with the reflex decrease in blood pressure elicited at rest, neck suction elicited an augmented decrease in blood pressure at 0-5 and 10-15 s during low-intensity exercise and in all periods during moderate-intensity exercise (P < 0.05). The reflex depressor response at the onset of cycling was primarily mediated by an increase in the total vascular conductance. These findings evidence altered carotid baroreflex function during the first 35 s of cycling compared with rest, with attenuated bradycardic response, and augmented depressor response to carotid baroreceptor stimulation.
U2 - 10.1152/ajpregu.00173.2016
DO - 10.1152/ajpregu.00173.2016
M3 - Journal article
C2 - 27581812
VL - 311
SP - R870-R878
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 5
ER -
ID: 169408957