Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

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Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. / Due-Andersen, Rikke; Høi-Hansen, Thomas; Olsen, Niels Vidiendal; Larroude, Charlotte Ellen; Kanters, Jørgen Kim; Boomsma, Frans; Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger.

I: Europace, Bind 10, Nr. 2, 2008, s. 219-26.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Due-Andersen, R, Høi-Hansen, T, Olsen, NV, Larroude, CE, Kanters, JK, Boomsma, F, Pedersen-Bjergaard, U & Thorsteinsson, B 2008, 'Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity.', Europace, bind 10, nr. 2, s. 219-26. https://doi.org/10.1093/europace/eum286

APA

Due-Andersen, R., Høi-Hansen, T., Olsen, N. V., Larroude, C. E., Kanters, J. K., Boomsma, F., Pedersen-Bjergaard, U., & Thorsteinsson, B. (2008). Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. Europace, 10(2), 219-26. https://doi.org/10.1093/europace/eum286

Vancouver

Due-Andersen R, Høi-Hansen T, Olsen NV, Larroude CE, Kanters JK, Boomsma F o.a. Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. Europace. 2008;10(2):219-26. https://doi.org/10.1093/europace/eum286

Author

Due-Andersen, Rikke ; Høi-Hansen, Thomas ; Olsen, Niels Vidiendal ; Larroude, Charlotte Ellen ; Kanters, Jørgen Kim ; Boomsma, Frans ; Pedersen-Bjergaard, Ulrik ; Thorsteinsson, Birger. / Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. I: Europace. 2008 ; Bind 10, Nr. 2. s. 219-26.

Bibtex

@article{0ddc5f70ab5c11ddb5e9000ea68e967b,
title = "Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity.",
abstract = "AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans. METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables. CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.",
author = "Rikke Due-Andersen and Thomas H{\o}i-Hansen and Olsen, {Niels Vidiendal} and Larroude, {Charlotte Ellen} and Kanters, {J{\o}rgen Kim} and Frans Boomsma and Ulrik Pedersen-Bjergaard and Birger Thorsteinsson",
note = "Keywords: Adult; Anoxia; Cross-Over Studies; Electrocardiography, Ambulatory; Humans; Hypoglycemia; Insulin; Long QT Syndrome; Male; Oxygen Inhalation Therapy; Renin-Angiotensin System; Risk Factors; Single-Blind Method",
year = "2008",
doi = "10.1093/europace/eum286",
language = "English",
volume = "10",
pages = "219--26",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity.

AU - Due-Andersen, Rikke

AU - Høi-Hansen, Thomas

AU - Olsen, Niels Vidiendal

AU - Larroude, Charlotte Ellen

AU - Kanters, Jørgen Kim

AU - Boomsma, Frans

AU - Pedersen-Bjergaard, Ulrik

AU - Thorsteinsson, Birger

N1 - Keywords: Adult; Anoxia; Cross-Over Studies; Electrocardiography, Ambulatory; Humans; Hypoglycemia; Insulin; Long QT Syndrome; Male; Oxygen Inhalation Therapy; Renin-Angiotensin System; Risk Factors; Single-Blind Method

PY - 2008

Y1 - 2008

N2 - AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans. METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables. CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.

AB - AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans. METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables. CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.

U2 - 10.1093/europace/eum286

DO - 10.1093/europace/eum286

M3 - Journal article

C2 - 18204042

VL - 10

SP - 219

EP - 226

JO - Europace

JF - Europace

SN - 1099-5129

IS - 2

ER -

ID: 8419596