Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate

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Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate. / Holst, Jens Juul; Hartmann, Bolette; Gottschalck, Ida B; Jeppesen, Palle B; Miholic, Johannes; Henriksen, Dennis Bang.

I: Scandinavian Journal of Gastroenterology, Bind 42, Nr. 7, 07.2007, s. 814-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Holst, JJ, Hartmann, B, Gottschalck, IB, Jeppesen, PB, Miholic, J & Henriksen, DB 2007, 'Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate', Scandinavian Journal of Gastroenterology, bind 42, nr. 7, s. 814-20. https://doi.org/10.1080/00365520601137272

APA

Holst, J. J., Hartmann, B., Gottschalck, I. B., Jeppesen, P. B., Miholic, J., & Henriksen, D. B. (2007). Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate. Scandinavian Journal of Gastroenterology, 42(7), 814-20. https://doi.org/10.1080/00365520601137272

Vancouver

Holst JJ, Hartmann B, Gottschalck IB, Jeppesen PB, Miholic J, Henriksen DB. Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate. Scandinavian Journal of Gastroenterology. 2007 jul.;42(7):814-20. https://doi.org/10.1080/00365520601137272

Author

Holst, Jens Juul ; Hartmann, Bolette ; Gottschalck, Ida B ; Jeppesen, Palle B ; Miholic, Johannes ; Henriksen, Dennis Bang. / Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate. I: Scandinavian Journal of Gastroenterology. 2007 ; Bind 42, Nr. 7. s. 814-20.

Bibtex

@article{9335b137f8944cc181234daf501c4e3e,
title = "Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate",
abstract = "OBJECTIVE: Food intake inhibits bone resorption by a mechanism thought to involve gut hormones, and the intestinotrophic glucagon-like peptide 2 (GLP-2) is a candidate because exogenous GLP-2 inhibits bone resorption in humans. The purpose of the study was to investigate patients with short-bowel syndrome (SBS) or total gastrectomy in order to elucidate whether the signal for the meal-induced reduction of bone resorption is initiated from the stomach or the intestine.MATERIAL AND METHODS: Bone resorption was assessed from the serum concentration of collagen type I C-telopeptide cross-links (s-CTX) and compared with the plasma concentrations of GLP-2. Bone formation was assessed from serum osteocalcin concentrations. Seven SBS patients with a preserved colon and 7 with SBS and colectomy and 7 healthy controls were given a breakfast test meal (936 kcal). Eight patients who had undergone total gastrectomy had an oral glucose load (75 g in 150 ml).RESULTS: The SBS patients without a colon showed no reduction in bone resorption (s-CTX) to a meal, whereas SBS patients with a colon had an intermediate response with a 27% (p<0.05) reduction of s-CTX from baseline after 120 min as compared with 66% (p<0.001) for normal controls. A significant reduction of 53% (p<0.001) was seen in gastrectomized patients after receiving oral glucose, which is comparable with the published data for the oral glucose tolerance test (OGGT) in healthy subjects (50% reduction over 120 min). Bone formation was unchanged for both SBS and gastrectomy patients. GLP-2 concentrations increased significantly in all groups with the exception of the SBS plus colectomy group.CONCLUSIONS: An intestinal factor is responsible for the postprandial reduction in bone resorption, and our findings are compatible with such a function for GLP-2.",
keywords = "Adult, Aged, Bone Resorption, Colectomy, Collagen Type I, Gastrectomy, Gastrointestinal Tract, Glucagon-Like Peptide 2, Humans, Middle Aged, Osteocalcin, Osteogenesis, Peptides, Postprandial Period, Short Bowel Syndrome",
author = "Holst, {Jens Juul} and Bolette Hartmann and Gottschalck, {Ida B} and Jeppesen, {Palle B} and Johannes Miholic and Henriksen, {Dennis Bang}",
year = "2007",
month = jul,
doi = "10.1080/00365520601137272",
language = "English",
volume = "42",
pages = "814--20",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Gottschalck, Ida B

AU - Jeppesen, Palle B

AU - Miholic, Johannes

AU - Henriksen, Dennis Bang

PY - 2007/7

Y1 - 2007/7

N2 - OBJECTIVE: Food intake inhibits bone resorption by a mechanism thought to involve gut hormones, and the intestinotrophic glucagon-like peptide 2 (GLP-2) is a candidate because exogenous GLP-2 inhibits bone resorption in humans. The purpose of the study was to investigate patients with short-bowel syndrome (SBS) or total gastrectomy in order to elucidate whether the signal for the meal-induced reduction of bone resorption is initiated from the stomach or the intestine.MATERIAL AND METHODS: Bone resorption was assessed from the serum concentration of collagen type I C-telopeptide cross-links (s-CTX) and compared with the plasma concentrations of GLP-2. Bone formation was assessed from serum osteocalcin concentrations. Seven SBS patients with a preserved colon and 7 with SBS and colectomy and 7 healthy controls were given a breakfast test meal (936 kcal). Eight patients who had undergone total gastrectomy had an oral glucose load (75 g in 150 ml).RESULTS: The SBS patients without a colon showed no reduction in bone resorption (s-CTX) to a meal, whereas SBS patients with a colon had an intermediate response with a 27% (p<0.05) reduction of s-CTX from baseline after 120 min as compared with 66% (p<0.001) for normal controls. A significant reduction of 53% (p<0.001) was seen in gastrectomized patients after receiving oral glucose, which is comparable with the published data for the oral glucose tolerance test (OGGT) in healthy subjects (50% reduction over 120 min). Bone formation was unchanged for both SBS and gastrectomy patients. GLP-2 concentrations increased significantly in all groups with the exception of the SBS plus colectomy group.CONCLUSIONS: An intestinal factor is responsible for the postprandial reduction in bone resorption, and our findings are compatible with such a function for GLP-2.

AB - OBJECTIVE: Food intake inhibits bone resorption by a mechanism thought to involve gut hormones, and the intestinotrophic glucagon-like peptide 2 (GLP-2) is a candidate because exogenous GLP-2 inhibits bone resorption in humans. The purpose of the study was to investigate patients with short-bowel syndrome (SBS) or total gastrectomy in order to elucidate whether the signal for the meal-induced reduction of bone resorption is initiated from the stomach or the intestine.MATERIAL AND METHODS: Bone resorption was assessed from the serum concentration of collagen type I C-telopeptide cross-links (s-CTX) and compared with the plasma concentrations of GLP-2. Bone formation was assessed from serum osteocalcin concentrations. Seven SBS patients with a preserved colon and 7 with SBS and colectomy and 7 healthy controls were given a breakfast test meal (936 kcal). Eight patients who had undergone total gastrectomy had an oral glucose load (75 g in 150 ml).RESULTS: The SBS patients without a colon showed no reduction in bone resorption (s-CTX) to a meal, whereas SBS patients with a colon had an intermediate response with a 27% (p<0.05) reduction of s-CTX from baseline after 120 min as compared with 66% (p<0.001) for normal controls. A significant reduction of 53% (p<0.001) was seen in gastrectomized patients after receiving oral glucose, which is comparable with the published data for the oral glucose tolerance test (OGGT) in healthy subjects (50% reduction over 120 min). Bone formation was unchanged for both SBS and gastrectomy patients. GLP-2 concentrations increased significantly in all groups with the exception of the SBS plus colectomy group.CONCLUSIONS: An intestinal factor is responsible for the postprandial reduction in bone resorption, and our findings are compatible with such a function for GLP-2.

KW - Adult

KW - Aged

KW - Bone Resorption

KW - Colectomy

KW - Collagen Type I

KW - Gastrectomy

KW - Gastrointestinal Tract

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Middle Aged

KW - Osteocalcin

KW - Osteogenesis

KW - Peptides

KW - Postprandial Period

KW - Short Bowel Syndrome

U2 - 10.1080/00365520601137272

DO - 10.1080/00365520601137272

M3 - Journal article

C2 - 17558904

VL - 42

SP - 814

EP - 820

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 7

ER -

ID: 132050059