Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood

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Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. / Gram, Anne Sofie; Skov, Jane; Ploug, Thorkil; Sidelmann, Johannes J; Stallknecht, Bente M; Bladbjerg, Else-M.

I: Blood Coagulation and Fibrinolysis, Bind 25, Nr. 4, 06.2014, s. 349-52.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gram, AS, Skov, J, Ploug, T, Sidelmann, JJ, Stallknecht, BM & Bladbjerg, E-M 2014, 'Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood', Blood Coagulation and Fibrinolysis, bind 25, nr. 4, s. 349-52. https://doi.org/10.1097/MBC.0000000000000041

APA

Gram, A. S., Skov, J., Ploug, T., Sidelmann, J. J., Stallknecht, B. M., & Bladbjerg, E-M. (2014). Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. Blood Coagulation and Fibrinolysis, 25(4), 349-52. https://doi.org/10.1097/MBC.0000000000000041

Vancouver

Gram AS, Skov J, Ploug T, Sidelmann JJ, Stallknecht BM, Bladbjerg E-M. Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. Blood Coagulation and Fibrinolysis. 2014 jun;25(4):349-52. https://doi.org/10.1097/MBC.0000000000000041

Author

Gram, Anne Sofie ; Skov, Jane ; Ploug, Thorkil ; Sidelmann, Johannes J ; Stallknecht, Bente M ; Bladbjerg, Else-M. / Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. I: Blood Coagulation and Fibrinolysis. 2014 ; Bind 25, Nr. 4. s. 349-52.

Bibtex

@article{9e373014ddfa499c97a2bff712302314,
title = "Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood",
abstract = "Effects of venous blood arterialization on cardiovascular risk markers are still unknown. We evaluated biomarkers of inflammation, coagulation, fibrinolysis, and endothelial function in arterialized compared with regular venous blood. Cubital venipunctures were obtained from 10 healthy volunteers. Arterialization was generated by 10 min heating of the contralateral hand. Concentrations of albumin, C-reactive protein (CRP), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF) were measured by validated assays. Concentrations of albumin, CRP, and vWF were significantly lower in arterialized than in venous blood (albumin: 43.8 g/l and 44.8 g/l, P = 0.02). Differences in CRP and vWF became insignificant after adjusting for albumin. The endogenous thrombin potential (ETP) was significantly higher in arterialized than in venous blood (1929 nmol/l*min vs. 1872 nmol/l*min, P = 0.02). Addition of the FXIIa inhibitor Corn Trypsin Inhibitor (CTI) prior to the thrombin generation test eliminated the ETP difference suggesting that hand heating activates the FXII-dependent coagulation pathway.",
author = "Gram, {Anne Sofie} and Jane Skov and Thorkil Ploug and Sidelmann, {Johannes J} and Stallknecht, {Bente M} and Else-M Bladbjerg",
year = "2014",
month = "6",
doi = "10.1097/MBC.0000000000000041",
language = "English",
volume = "25",
pages = "349--52",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood

AU - Gram, Anne Sofie

AU - Skov, Jane

AU - Ploug, Thorkil

AU - Sidelmann, Johannes J

AU - Stallknecht, Bente M

AU - Bladbjerg, Else-M

PY - 2014/6

Y1 - 2014/6

N2 - Effects of venous blood arterialization on cardiovascular risk markers are still unknown. We evaluated biomarkers of inflammation, coagulation, fibrinolysis, and endothelial function in arterialized compared with regular venous blood. Cubital venipunctures were obtained from 10 healthy volunteers. Arterialization was generated by 10 min heating of the contralateral hand. Concentrations of albumin, C-reactive protein (CRP), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF) were measured by validated assays. Concentrations of albumin, CRP, and vWF were significantly lower in arterialized than in venous blood (albumin: 43.8 g/l and 44.8 g/l, P = 0.02). Differences in CRP and vWF became insignificant after adjusting for albumin. The endogenous thrombin potential (ETP) was significantly higher in arterialized than in venous blood (1929 nmol/l*min vs. 1872 nmol/l*min, P = 0.02). Addition of the FXIIa inhibitor Corn Trypsin Inhibitor (CTI) prior to the thrombin generation test eliminated the ETP difference suggesting that hand heating activates the FXII-dependent coagulation pathway.

AB - Effects of venous blood arterialization on cardiovascular risk markers are still unknown. We evaluated biomarkers of inflammation, coagulation, fibrinolysis, and endothelial function in arterialized compared with regular venous blood. Cubital venipunctures were obtained from 10 healthy volunteers. Arterialization was generated by 10 min heating of the contralateral hand. Concentrations of albumin, C-reactive protein (CRP), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand factor (vWF) were measured by validated assays. Concentrations of albumin, CRP, and vWF were significantly lower in arterialized than in venous blood (albumin: 43.8 g/l and 44.8 g/l, P = 0.02). Differences in CRP and vWF became insignificant after adjusting for albumin. The endogenous thrombin potential (ETP) was significantly higher in arterialized than in venous blood (1929 nmol/l*min vs. 1872 nmol/l*min, P = 0.02). Addition of the FXIIa inhibitor Corn Trypsin Inhibitor (CTI) prior to the thrombin generation test eliminated the ETP difference suggesting that hand heating activates the FXII-dependent coagulation pathway.

U2 - 10.1097/MBC.0000000000000041

DO - 10.1097/MBC.0000000000000041

M3 - Journal article

C2 - 24434349

VL - 25

SP - 349

EP - 352

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 4

ER -

ID: 117921288