Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

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Standard

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. / Christiansen, Charlotte Bayer; Trammell, Samuel Addison Jack; Albrechtsen, Nicolai Jacob Wewer; Schoonjans, Kristina; Albrechtsen, Reidar; Gillum, Matthew Paul; Kuhre, Rune Ehrenreich; Holst, Jens Juul.

I: American Journal of Physiology: Gastrointestinal and Liver Physiology, Bind 316, Nr. 5, 2019, s. G574-G584.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Christiansen, CB, Trammell, SAJ, Albrechtsen, NJW, Schoonjans, K, Albrechtsen, R, Gillum, MP, Kuhre, RE & Holst, JJ 2019, 'Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents', American Journal of Physiology: Gastrointestinal and Liver Physiology, bind 316, nr. 5, s. G574-G584. https://doi.org/10.1152/ajpgi.00010.2019

APA

Christiansen, C. B., Trammell, S. A. J., Albrechtsen, N. J. W., Schoonjans, K., Albrechtsen, R., Gillum, M. P., ... Holst, J. J. (2019). Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. American Journal of Physiology: Gastrointestinal and Liver Physiology, 316(5), G574-G584. https://doi.org/10.1152/ajpgi.00010.2019

Vancouver

Christiansen CB, Trammell SAJ, Albrechtsen NJW, Schoonjans K, Albrechtsen R, Gillum MP o.a. Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2019;316(5):G574-G584. https://doi.org/10.1152/ajpgi.00010.2019

Author

Christiansen, Charlotte Bayer ; Trammell, Samuel Addison Jack ; Albrechtsen, Nicolai Jacob Wewer ; Schoonjans, Kristina ; Albrechtsen, Reidar ; Gillum, Matthew Paul ; Kuhre, Rune Ehrenreich ; Holst, Jens Juul. / Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. I: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2019 ; Bind 316, Nr. 5. s. G574-G584.

Bibtex

@article{69aff6aac0464947b4107492f9b06f7e,
title = "Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents",
abstract = "A large number of glucagon-like-peptide 1 (GLP-1) and peptide-YY (PYY) producing L-cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs spill over from the ileum to the colon, we decided to investigate the ability of BAs to stimulate colonic GLP-1 and PYY secretion. Using isolated perfused rat/mouse colon as well as stimulation of the rat colon in vivo, we demonstrate that BAs significantly enhance secretion of GLP-1 and PYY from the colon with average increases of 3.5 and 2.9-fold, respectively. Furthermore, we find that responses depend on BA absorption followed by basolateral activation of the BA-receptor, TGR5. Surprisingly, the apical sodium-dependent-bile-acid-transporter (IBAT), which serves to absorb conjugated BAs, was not required for colonic conjugated BA absorption or conjugated BA-induced peptide secretion. In conclusion, we demonstrate that BAs represent a major physiological stimulus for colonic L-cell secretion.",
author = "Christiansen, {Charlotte Bayer} and Trammell, {Samuel Addison Jack} and Albrechtsen, {Nicolai Jacob Wewer} and Kristina Schoonjans and Reidar Albrechtsen and Gillum, {Matthew Paul} and Kuhre, {Rune Ehrenreich} and Holst, {Jens Juul}",
year = "2019",
doi = "10.1152/ajpgi.00010.2019",
language = "English",
volume = "316",
pages = "G574--G584",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

AU - Christiansen, Charlotte Bayer

AU - Trammell, Samuel Addison Jack

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Schoonjans, Kristina

AU - Albrechtsen, Reidar

AU - Gillum, Matthew Paul

AU - Kuhre, Rune Ehrenreich

AU - Holst, Jens Juul

PY - 2019

Y1 - 2019

N2 - A large number of glucagon-like-peptide 1 (GLP-1) and peptide-YY (PYY) producing L-cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs spill over from the ileum to the colon, we decided to investigate the ability of BAs to stimulate colonic GLP-1 and PYY secretion. Using isolated perfused rat/mouse colon as well as stimulation of the rat colon in vivo, we demonstrate that BAs significantly enhance secretion of GLP-1 and PYY from the colon with average increases of 3.5 and 2.9-fold, respectively. Furthermore, we find that responses depend on BA absorption followed by basolateral activation of the BA-receptor, TGR5. Surprisingly, the apical sodium-dependent-bile-acid-transporter (IBAT), which serves to absorb conjugated BAs, was not required for colonic conjugated BA absorption or conjugated BA-induced peptide secretion. In conclusion, we demonstrate that BAs represent a major physiological stimulus for colonic L-cell secretion.

AB - A large number of glucagon-like-peptide 1 (GLP-1) and peptide-YY (PYY) producing L-cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs spill over from the ileum to the colon, we decided to investigate the ability of BAs to stimulate colonic GLP-1 and PYY secretion. Using isolated perfused rat/mouse colon as well as stimulation of the rat colon in vivo, we demonstrate that BAs significantly enhance secretion of GLP-1 and PYY from the colon with average increases of 3.5 and 2.9-fold, respectively. Furthermore, we find that responses depend on BA absorption followed by basolateral activation of the BA-receptor, TGR5. Surprisingly, the apical sodium-dependent-bile-acid-transporter (IBAT), which serves to absorb conjugated BAs, was not required for colonic conjugated BA absorption or conjugated BA-induced peptide secretion. In conclusion, we demonstrate that BAs represent a major physiological stimulus for colonic L-cell secretion.

U2 - 10.1152/ajpgi.00010.2019

DO - 10.1152/ajpgi.00010.2019

M3 - Journal article

C2 - 30767682

VL - 316

SP - G574-G584

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 5

ER -

ID: 214748361