Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study. / Wilkens, Trine Levring; Sørensen, Helle; Jensen, Majken Karoline; Furtado, Jeremy D; Dragsted, Lars Ove; Mukamal, Kenneth J.

I: Current Problems in Cardiology, Bind 48, Nr. 1, 101395, 2023.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Wilkens, TL, Sørensen, H, Jensen, MK, Furtado, JD, Dragsted, LO & Mukamal, KJ 2023, 'Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study', Current Problems in Cardiology, bind 48, nr. 1, 101395. https://doi.org/10.1016/j.cpcardiol.2022.101395

APA

Wilkens, T. L., Sørensen, H., Jensen, M. K., Furtado, J. D., Dragsted, L. O., & Mukamal, K. J. (2023). Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study. Current Problems in Cardiology, 48(1), [101395]. https://doi.org/10.1016/j.cpcardiol.2022.101395

Vancouver

Wilkens TL, Sørensen H, Jensen MK, Furtado JD, Dragsted LO, Mukamal KJ. Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study. Current Problems in Cardiology. 2023;48(1). 101395. https://doi.org/10.1016/j.cpcardiol.2022.101395

Author

Wilkens, Trine Levring ; Sørensen, Helle ; Jensen, Majken Karoline ; Furtado, Jeremy D ; Dragsted, Lars Ove ; Mukamal, Kenneth J. / Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study. I: Current Problems in Cardiology. 2023 ; Bind 48, Nr. 1.

Bibtex

@article{63c51a83464f4875bc579212eb4342aa,
title = "Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study",
abstract = "Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10−9, subspecies with the apolipoproteins, P ≤ 3 × 10−5). Total apoA1 was also directly associated with alcohol consumption, with a 1% increase per additional drink per week (P = 1 × 10−14). Total apoC3 blood levels were 0.5% higher per additional drink per week (P = 0.01), but the association was driven by a few heavily drinking men. Alcohol intake was positively associated with HDL subspecies lacking and containing apoC3, apoE, or apoJ, and with total plasma apoA1. ApoC3 was directly, albeit not as robustly associated with alcohol intake. HDL protein cargo is crucial for its anti-atherosclerotic functions, but it remains to be determined whether HDL subspecies play a role in the putative association between limited alcohol intake and lower risk of coronary heart disease.",
keywords = "Faculty of Science, High-density lipoprotein, Lipoprotein subspecies, Alcohol consumption, Cardiovascular disease, Apolipoproteins, ApoC3, ApoE",
author = "Wilkens, {Trine Levring} and Helle S{\o}rensen and Jensen, {Majken Karoline} and Furtado, {Jeremy D} and Dragsted, {Lars Ove} and Mukamal, {Kenneth J}",
note = "CURIS 2023 NEXS 001",
year = "2023",
doi = "10.1016/j.cpcardiol.2022.101395",
language = "English",
volume = "48",
journal = "Current Problems in Cardiology",
issn = "0146-2806",
publisher = "Mosby Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Associations between alcohol consumption and HDL subspecies defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study

AU - Wilkens, Trine Levring

AU - Sørensen, Helle

AU - Jensen, Majken Karoline

AU - Furtado, Jeremy D

AU - Dragsted, Lars Ove

AU - Mukamal, Kenneth J

N1 - CURIS 2023 NEXS 001

PY - 2023

Y1 - 2023

N2 - Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10−9, subspecies with the apolipoproteins, P ≤ 3 × 10−5). Total apoA1 was also directly associated with alcohol consumption, with a 1% increase per additional drink per week (P = 1 × 10−14). Total apoC3 blood levels were 0.5% higher per additional drink per week (P = 0.01), but the association was driven by a few heavily drinking men. Alcohol intake was positively associated with HDL subspecies lacking and containing apoC3, apoE, or apoJ, and with total plasma apoA1. ApoC3 was directly, albeit not as robustly associated with alcohol intake. HDL protein cargo is crucial for its anti-atherosclerotic functions, but it remains to be determined whether HDL subspecies play a role in the putative association between limited alcohol intake and lower risk of coronary heart disease.

AB - Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10−9, subspecies with the apolipoproteins, P ≤ 3 × 10−5). Total apoA1 was also directly associated with alcohol consumption, with a 1% increase per additional drink per week (P = 1 × 10−14). Total apoC3 blood levels were 0.5% higher per additional drink per week (P = 0.01), but the association was driven by a few heavily drinking men. Alcohol intake was positively associated with HDL subspecies lacking and containing apoC3, apoE, or apoJ, and with total plasma apoA1. ApoC3 was directly, albeit not as robustly associated with alcohol intake. HDL protein cargo is crucial for its anti-atherosclerotic functions, but it remains to be determined whether HDL subspecies play a role in the putative association between limited alcohol intake and lower risk of coronary heart disease.

KW - Faculty of Science

KW - High-density lipoprotein

KW - Lipoprotein subspecies

KW - Alcohol consumption

KW - Cardiovascular disease

KW - Apolipoproteins

KW - ApoC3

KW - ApoE

U2 - 10.1016/j.cpcardiol.2022.101395

DO - 10.1016/j.cpcardiol.2022.101395

M3 - Journal article

C2 - 36096454

VL - 48

JO - Current Problems in Cardiology

JF - Current Problems in Cardiology

SN - 0146-2806

IS - 1

M1 - 101395

ER -

ID: 319780875