Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction. / Jabbari, Reza; Jabbari, Javad; Glinge, Charlotte; Risgaard, Bjarke; Sattler, Stefan; Winkel, Bo Gregers; Terkelsen, Christian Juhl; Tilsted, Hans Henrik; Jensen, Lisette Okkels; Hougaard, Mikkel; Haunsø, Stig; Engstrøm, Thomas; Albert, Christine M.; Tfelt-Hansen, Jacob.

I: BMC Medical Genetics, Bind 18, 138, 21.11.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jabbari, R, Jabbari, J, Glinge, C, Risgaard, B, Sattler, S, Winkel, BG, Terkelsen, CJ, Tilsted, HH, Jensen, LO, Hougaard, M, Haunsø, S, Engstrøm, T, Albert, CM & Tfelt-Hansen, J 2017, 'Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction', BMC Medical Genetics, bind 18, 138. https://doi.org/10.1186/s12881-017-0497-1

APA

Jabbari, R., Jabbari, J., Glinge, C., Risgaard, B., Sattler, S., Winkel, B. G., ... Tfelt-Hansen, J. (2017). Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction. BMC Medical Genetics, 18, [138]. https://doi.org/10.1186/s12881-017-0497-1

Vancouver

Jabbari R, Jabbari J, Glinge C, Risgaard B, Sattler S, Winkel BG o.a. Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction. BMC Medical Genetics. 2017 nov 21;18. 138. https://doi.org/10.1186/s12881-017-0497-1

Author

Jabbari, Reza ; Jabbari, Javad ; Glinge, Charlotte ; Risgaard, Bjarke ; Sattler, Stefan ; Winkel, Bo Gregers ; Terkelsen, Christian Juhl ; Tilsted, Hans Henrik ; Jensen, Lisette Okkels ; Hougaard, Mikkel ; Haunsø, Stig ; Engstrøm, Thomas ; Albert, Christine M. ; Tfelt-Hansen, Jacob. / Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction. I: BMC Medical Genetics. 2017 ; Bind 18.

Bibtex

@article{ebad67aba815482d99147422d3d49e72,
title = "Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction",
abstract = "Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86{\%} vs. 75{\%}, p = 0.001), have a history of AF (7{\%} vs. 2{\%}, p = 0.006) or hypercholesterolemia (39{\%} vs. 31{\%}, p = 0.023), and a family history of sudden death (40{\%} vs. 25{\%}, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model. Conclusion: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.",
keywords = "Atrial fibrillation, Genetics, Myocardial infarction, Single nucleotide polymorphisms, ST-elevation myocardial infarction, Sudden cardiac death, Ventricular fibrillation",
author = "Reza Jabbari and Javad Jabbari and Charlotte Glinge and Bjarke Risgaard and Stefan Sattler and Winkel, {Bo Gregers} and Terkelsen, {Christian Juhl} and Tilsted, {Hans Henrik} and Jensen, {Lisette Okkels} and Mikkel Hougaard and Stig Hauns{\o} and Thomas Engstr{\o}m and Albert, {Christine M.} and Jacob Tfelt-Hansen",
year = "2017",
month = "11",
day = "21",
doi = "10.1186/s12881-017-0497-1",
language = "English",
volume = "18",
journal = "B M C Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

AU - Jabbari, Reza

AU - Jabbari, Javad

AU - Glinge, Charlotte

AU - Risgaard, Bjarke

AU - Sattler, Stefan

AU - Winkel, Bo Gregers

AU - Terkelsen, Christian Juhl

AU - Tilsted, Hans Henrik

AU - Jensen, Lisette Okkels

AU - Hougaard, Mikkel

AU - Haunsø, Stig

AU - Engstrøm, Thomas

AU - Albert, Christine M.

AU - Tfelt-Hansen, Jacob

PY - 2017/11/21

Y1 - 2017/11/21

N2 - Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model. Conclusion: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

AB - Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model. Conclusion: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

KW - Atrial fibrillation

KW - Genetics

KW - Myocardial infarction

KW - Single nucleotide polymorphisms

KW - ST-elevation myocardial infarction

KW - Sudden cardiac death

KW - Ventricular fibrillation

U2 - 10.1186/s12881-017-0497-1

DO - 10.1186/s12881-017-0497-1

M3 - Journal article

VL - 18

JO - B M C Medical Genetics

JF - B M C Medical Genetics

SN - 1471-2350

M1 - 138

ER -

ID: 190433006