Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.
Originalsprog | Engelsk |
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Tidsskrift | Atherosclerosis |
Vol/bind | 221 |
Udgave nummer | 1 |
Sider (fra-til) | 91-7 |
Antal sider | 7 |
ISSN | 0021-9150 |
DOI | |
Status | Udgivet - 2012 |
ID: 38431824