Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

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Standard

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. / Elsøe, Sara; Ahnström, Josefin; Christoffersen, Christina; Hoofnagle, Andrew N; Plomgaard, Peter; Heinecke, Jay W; Binder, Christoph J; Björkbacka, Harry; Dahlbäck, Björn; Nielsen, Lars Bo.

I: Atherosclerosis, Bind 221, Nr. 1, 2012, s. 91-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Elsøe, S, Ahnström, J, Christoffersen, C, Hoofnagle, AN, Plomgaard, P, Heinecke, JW, Binder, CJ, Björkbacka, H, Dahlbäck, B & Nielsen, LB 2012, 'Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL', Atherosclerosis, bind 221, nr. 1, s. 91-7. https://doi.org/10.1016/j.atherosclerosis.2011.11.031

APA

Elsøe, S., Ahnström, J., Christoffersen, C., Hoofnagle, A. N., Plomgaard, P., Heinecke, J. W., Binder, C. J., Björkbacka, H., Dahlbäck, B., & Nielsen, L. B. (2012). Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis, 221(1), 91-7. https://doi.org/10.1016/j.atherosclerosis.2011.11.031

Vancouver

Elsøe S, Ahnström J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW o.a. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis. 2012;221(1):91-7. https://doi.org/10.1016/j.atherosclerosis.2011.11.031

Author

Elsøe, Sara ; Ahnström, Josefin ; Christoffersen, Christina ; Hoofnagle, Andrew N ; Plomgaard, Peter ; Heinecke, Jay W ; Binder, Christoph J ; Björkbacka, Harry ; Dahlbäck, Björn ; Nielsen, Lars Bo. / Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. I: Atherosclerosis. 2012 ; Bind 221, Nr. 1. s. 91-7.

Bibtex

@article{d0a3aeb48c9441d2ba7293510fff8fba,

title = "Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL",

abstract = "Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.",

keywords = "Amidines, Animals, Antioxidants, Apolipoproteins, Atherosclerosis, Binding Sites, Cholesterol, Dietary, Disease Models, Animal, Humans, Lipocalins, Lipoproteins, HDL, Lipoproteins, LDL, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myristic Acid, Oxidants, Oxidation-Reduction, Phospholipids, Receptors, LDL, Recombinant Proteins, Thiobarbituric Acid Reactive Substances, Time Factors",

author = "Sara Els{\o}e and Josefin Ahnstr{\"o}m and Christina Christoffersen and Hoofnagle, {Andrew N} and Peter Plomgaard and Heinecke, {Jay W} and Binder, {Christoph J} and Harry Bj{\"o}rkbacka and Bj{\"o}rn Dahlb{\"a}ck and Nielsen, {Lars Bo}",

year = "2012",

doi = "10.1016/j.atherosclerosis.2011.11.031",

language = "English",

volume = "221",

pages = "91--7",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

AU - Elsøe, Sara

AU - Ahnström, Josefin

AU - Christoffersen, Christina

AU - Hoofnagle, Andrew N

AU - Plomgaard, Peter

AU - Heinecke, Jay W

AU - Binder, Christoph J

AU - Björkbacka, Harry

AU - Dahlbäck, Björn

AU - Nielsen, Lars Bo

PY - 2012

Y1 - 2012

N2 - Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.

AB - Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.

KW - Amidines

KW - Animals

KW - Antioxidants

KW - Apolipoproteins

KW - Atherosclerosis

KW - Binding Sites

KW - Cholesterol, Dietary

KW - Disease Models, Animal

KW - Humans

KW - Lipocalins

KW - Lipoproteins, HDL

KW - Lipoproteins, LDL

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Transgenic

KW - Myristic Acid

KW - Oxidants

KW - Oxidation-Reduction

KW - Phospholipids

KW - Receptors, LDL

KW - Recombinant Proteins

KW - Thiobarbituric Acid Reactive Substances

KW - Time Factors

U2 - 10.1016/j.atherosclerosis.2011.11.031

DO - 10.1016/j.atherosclerosis.2011.11.031

M3 - Journal article

C2 - 22204862

VL - 221

SP - 91

EP - 97

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -

ID: 38431824

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