Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

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Standard

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. / Shim, Jeong; Poulsen, Christian Bo; Hagensen, Mette K.; Larsen, Torben; Heegaard, Peter M.H.; Christoffersen, Christina; Bolund, Lars; Schmidt, Mette; Liu, Ying; Li, Juan; Li, Rong; Callesen, Henrik; Bentzon, Jacob F.; Sørensen, Charlotte B.

I: JACC: Basic to Translational Science, Bind 2, Nr. 5, 2017, s. 591-600.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Shim, J, Poulsen, CB, Hagensen, MK, Larsen, T, Heegaard, PMH, Christoffersen, C, Bolund, L, Schmidt, M, Liu, Y, Li, J, Li, R, Callesen, H, Bentzon, JF & Sørensen, CB 2017, 'Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs', JACC: Basic to Translational Science, bind 2, nr. 5, s. 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

APA

Shim, J., Poulsen, C. B., Hagensen, M. K., Larsen, T., Heegaard, P. M. H., Christoffersen, C., ... Sørensen, C. B. (2017). Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. JACC: Basic to Translational Science, 2(5), 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

Vancouver

Shim J, Poulsen CB, Hagensen MK, Larsen T, Heegaard PMH, Christoffersen C o.a. Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. JACC: Basic to Translational Science. 2017;2(5):591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

Author

Shim, Jeong ; Poulsen, Christian Bo ; Hagensen, Mette K. ; Larsen, Torben ; Heegaard, Peter M.H. ; Christoffersen, Christina ; Bolund, Lars ; Schmidt, Mette ; Liu, Ying ; Li, Juan ; Li, Rong ; Callesen, Henrik ; Bentzon, Jacob F. ; Sørensen, Charlotte B. / Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. I: JACC: Basic to Translational Science. 2017 ; Bind 2, Nr. 5. s. 591-600.

Bibtex

@article{9070941818fb4095a4384df8d102d6b5,
title = "Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs",
abstract = "Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.",
keywords = "apolipoprotein E, atherosclerosis, pig, remnant cholesterol dysbetalipoproteinemia",
author = "Jeong Shim and Poulsen, {Christian Bo} and Hagensen, {Mette K.} and Torben Larsen and Heegaard, {Peter M.H.} and Christina Christoffersen and Lars Bolund and Mette Schmidt and Ying Liu and Juan Li and Rong Li and Henrik Callesen and Bentzon, {Jacob F.} and S{\o}rensen, {Charlotte B.}",
year = "2017",
doi = "10.1016/j.jacbts.2017.06.004",
language = "English",
volume = "2",
pages = "591--600",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

AU - Shim, Jeong

AU - Poulsen, Christian Bo

AU - Hagensen, Mette K.

AU - Larsen, Torben

AU - Heegaard, Peter M.H.

AU - Christoffersen, Christina

AU - Bolund, Lars

AU - Schmidt, Mette

AU - Liu, Ying

AU - Li, Juan

AU - Li, Rong

AU - Callesen, Henrik

AU - Bentzon, Jacob F.

AU - Sørensen, Charlotte B.

PY - 2017

Y1 - 2017

N2 - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

AB - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

KW - apolipoprotein E

KW - atherosclerosis

KW - pig

KW - remnant cholesterol dysbetalipoproteinemia

U2 - 10.1016/j.jacbts.2017.06.004

DO - 10.1016/j.jacbts.2017.06.004

M3 - Journal article

C2 - 30062172

AN - SCOPUS:85042148702

VL - 2

SP - 591

EP - 600

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 5

ER -

ID: 192815015