Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

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Standard

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. / Shim, Jeong; Poulsen, Christian Bo; Hagensen, Mette K.; Larsen, Torben; Heegaard, Peter M.H.; Christoffersen, Christina; Bolund, Lars; Schmidt, Mette; Liu, Ying; Li, Juan; Li, Rong; Callesen, Henrik; Bentzon, Jacob F.; Sørensen, Charlotte B.

I: JACC: Basic to Translational Science, Bind 2, Nr. 5, 2017, s. 591-600.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Shim, J, Poulsen, CB, Hagensen, MK, Larsen, T, Heegaard, PMH, Christoffersen, C, Bolund, L, Schmidt, M, Liu, Y, Li, J, Li, R, Callesen, H, Bentzon, JF & Sørensen, CB 2017, 'Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs', JACC: Basic to Translational Science, bind 2, nr. 5, s. 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

APA

Shim, J., Poulsen, C. B., Hagensen, M. K., Larsen, T., Heegaard, P. M. H., Christoffersen, C., Bolund, L., Schmidt, M., Liu, Y., Li, J., Li, R., Callesen, H., Bentzon, J. F., & Sørensen, C. B. (2017). Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. JACC: Basic to Translational Science, 2(5), 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

Vancouver

Shim J, Poulsen CB, Hagensen MK, Larsen T, Heegaard PMH, Christoffersen C o.a. Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. JACC: Basic to Translational Science. 2017;2(5):591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

Author

Shim, Jeong ; Poulsen, Christian Bo ; Hagensen, Mette K. ; Larsen, Torben ; Heegaard, Peter M.H. ; Christoffersen, Christina ; Bolund, Lars ; Schmidt, Mette ; Liu, Ying ; Li, Juan ; Li, Rong ; Callesen, Henrik ; Bentzon, Jacob F. ; Sørensen, Charlotte B. / Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. I: JACC: Basic to Translational Science. 2017 ; Bind 2, Nr. 5. s. 591-600.

Bibtex

@article{9070941818fb4095a4384df8d102d6b5,
title = "Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs",
abstract = "Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.",
keywords = "apolipoprotein E, atherosclerosis, pig, remnant cholesterol dysbetalipoproteinemia",
author = "Jeong Shim and Poulsen, {Christian Bo} and Hagensen, {Mette K.} and Torben Larsen and Heegaard, {Peter M.H.} and Christina Christoffersen and Lars Bolund and Mette Schmidt and Ying Liu and Juan Li and Rong Li and Henrik Callesen and Bentzon, {Jacob F.} and S{\o}rensen, {Charlotte B.}",
year = "2017",
doi = "10.1016/j.jacbts.2017.06.004",
language = "English",
volume = "2",
pages = "591--600",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

AU - Shim, Jeong

AU - Poulsen, Christian Bo

AU - Hagensen, Mette K.

AU - Larsen, Torben

AU - Heegaard, Peter M.H.

AU - Christoffersen, Christina

AU - Bolund, Lars

AU - Schmidt, Mette

AU - Liu, Ying

AU - Li, Juan

AU - Li, Rong

AU - Callesen, Henrik

AU - Bentzon, Jacob F.

AU - Sørensen, Charlotte B.

PY - 2017

Y1 - 2017

N2 - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

AB - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

KW - apolipoprotein E

KW - atherosclerosis

KW - pig

KW - remnant cholesterol dysbetalipoproteinemia

U2 - 10.1016/j.jacbts.2017.06.004

DO - 10.1016/j.jacbts.2017.06.004

M3 - Journal article

C2 - 30062172

AN - SCOPUS:85042148702

VL - 2

SP - 591

EP - 600

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 5

ER -

ID: 192815015