Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses

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Standard

Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. / Carstensen, Helena; Kjær, Line; Haugaard, Maria Mathilde; Flethøj, Mette; Hesselkilde, Eva Zander; Kanters, Jørgen K; Pehrson, Steen; Buhl, Rikke; Jespersen, Thomas.

I: Journal of Cardiovascular Pharmacology, Bind 71, Nr. 1, 01.2018, s. 26-35.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Carstensen, H, Kjær, L, Haugaard, MM, Flethøj, M, Hesselkilde, EZ, Kanters, JK, Pehrson, S, Buhl, R & Jespersen, T 2018, 'Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses', Journal of Cardiovascular Pharmacology, bind 71, nr. 1, s. 26-35. https://doi.org/10.1097/FJC.0000000000000541

APA

Carstensen, H., Kjær, L., Haugaard, M. M., Flethøj, M., Hesselkilde, E. Z., Kanters, J. K., ... Jespersen, T. (2018). Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. Journal of Cardiovascular Pharmacology, 71(1), 26-35. https://doi.org/10.1097/FJC.0000000000000541

Vancouver

Carstensen H, Kjær L, Haugaard MM, Flethøj M, Hesselkilde EZ, Kanters JK o.a. Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. Journal of Cardiovascular Pharmacology. 2018 jan;71(1):26-35. https://doi.org/10.1097/FJC.0000000000000541

Author

Carstensen, Helena ; Kjær, Line ; Haugaard, Maria Mathilde ; Flethøj, Mette ; Hesselkilde, Eva Zander ; Kanters, Jørgen K ; Pehrson, Steen ; Buhl, Rikke ; Jespersen, Thomas. / Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. I: Journal of Cardiovascular Pharmacology. 2018 ; Bind 71, Nr. 1. s. 26-35.

Bibtex

@article{055613e5852748439ae6c2de18c94d01,
title = "Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses",
abstract = "BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or noncardiac toxicity. Efficacy can be improved by combining 2 compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined.METHODS: Dofetilide, ranolazine, and a combination of these were administered in 4 incremental dosing regimens to horses with acutely pacing-induced AF. Time to cardioversion, atrial effective refractory period, and AF vulnerability and duration were assessed.RESULTS: Of 8 horses, 6 cardioverted to sinus rhythm after infusion with a combination of 0.889 μg/kg dofetilide and 0.104 mg/kg ranolazine. Two horses cardioverted with 0.104 mg/kg ranolazine alone, and 3 cardioverted with 0.889 μg/kg dofetilide alone. The combination therapy decreased AF vulnerability (P < 0.05) and AF duration (P < 0.05). No change in atrial effective refractory period was detected with any of the drugs.CONCLUSIONS: The combination of dofetilide and ranolazine showed increased antiarrhythmic effects on acutely induced AF in horses, affecting time to cardioversion, AF vulnerability, and AF duration.",
author = "Helena Carstensen and Line Kj{\ae}r and Haugaard, {Maria Mathilde} and Mette Fleth{\o}j and Hesselkilde, {Eva Zander} and Kanters, {J{\o}rgen K} and Steen Pehrson and Rikke Buhl and Thomas Jespersen",
year = "2018",
month = "1",
doi = "10.1097/FJC.0000000000000541",
language = "English",
volume = "71",
pages = "26--35",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses

AU - Carstensen, Helena

AU - Kjær, Line

AU - Haugaard, Maria Mathilde

AU - Flethøj, Mette

AU - Hesselkilde, Eva Zander

AU - Kanters, Jørgen K

AU - Pehrson, Steen

AU - Buhl, Rikke

AU - Jespersen, Thomas

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or noncardiac toxicity. Efficacy can be improved by combining 2 compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined.METHODS: Dofetilide, ranolazine, and a combination of these were administered in 4 incremental dosing regimens to horses with acutely pacing-induced AF. Time to cardioversion, atrial effective refractory period, and AF vulnerability and duration were assessed.RESULTS: Of 8 horses, 6 cardioverted to sinus rhythm after infusion with a combination of 0.889 μg/kg dofetilide and 0.104 mg/kg ranolazine. Two horses cardioverted with 0.104 mg/kg ranolazine alone, and 3 cardioverted with 0.889 μg/kg dofetilide alone. The combination therapy decreased AF vulnerability (P < 0.05) and AF duration (P < 0.05). No change in atrial effective refractory period was detected with any of the drugs.CONCLUSIONS: The combination of dofetilide and ranolazine showed increased antiarrhythmic effects on acutely induced AF in horses, affecting time to cardioversion, AF vulnerability, and AF duration.

AB - BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or noncardiac toxicity. Efficacy can be improved by combining 2 compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined.METHODS: Dofetilide, ranolazine, and a combination of these were administered in 4 incremental dosing regimens to horses with acutely pacing-induced AF. Time to cardioversion, atrial effective refractory period, and AF vulnerability and duration were assessed.RESULTS: Of 8 horses, 6 cardioverted to sinus rhythm after infusion with a combination of 0.889 μg/kg dofetilide and 0.104 mg/kg ranolazine. Two horses cardioverted with 0.104 mg/kg ranolazine alone, and 3 cardioverted with 0.889 μg/kg dofetilide alone. The combination therapy decreased AF vulnerability (P < 0.05) and AF duration (P < 0.05). No change in atrial effective refractory period was detected with any of the drugs.CONCLUSIONS: The combination of dofetilide and ranolazine showed increased antiarrhythmic effects on acutely induced AF in horses, affecting time to cardioversion, AF vulnerability, and AF duration.

U2 - 10.1097/FJC.0000000000000541

DO - 10.1097/FJC.0000000000000541

M3 - Journal article

C2 - 29068807

VL - 71

SP - 26

EP - 35

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 1

ER -

ID: 193663829