Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice
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Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice. / Ratner, Cecilia; Shin, Jae Hoon; Dwibedi, Chinmay; Tremaroli, Valentina; Bjerregaard, Anette; Hartmann, Bolette; Bäckhed, Fredrik; Leinninger, Gina; Seeley, Randy J.; Holst, Birgitte.
I: Endocrinology, Bind 162, Nr. 9, bqab130, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice
AU - Ratner, Cecilia
AU - Shin, Jae Hoon
AU - Dwibedi, Chinmay
AU - Tremaroli, Valentina
AU - Bjerregaard, Anette
AU - Hartmann, Bolette
AU - Bäckhed, Fredrik
AU - Leinninger, Gina
AU - Seeley, Randy J.
AU - Holst, Birgitte
N1 - Publisher Copyright: © The Author(s) 2021.
PY - 2021
Y1 - 2021
N2 - Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve gastrectomy (VSG). To explore a potential mechanistic role of NT in VSG, we performed sham or VSG surgeries in diet-induced obese NT receptor 1 (NTSR1) wild-type and knockout (ko) mice and compared their weight and fat mass loss, glucose tolerance, food intake, and food preference after surgery. NTSR1 ko mice had reduced initial anorexia and body fat loss. Additionally, NTSR1 ko mice had an attenuated reduction in fat preference following VSG. Results from this study suggest that NTSR1 signaling contributes to the potent effect of VSG to initially reduce food intake following VSG surgeries and potentially also on the effects on macronutrient selection induced by VSG. However, maintenance of long-term weight loss after VSG requires signals in addition to NT.
AB - Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve gastrectomy (VSG). To explore a potential mechanistic role of NT in VSG, we performed sham or VSG surgeries in diet-induced obese NT receptor 1 (NTSR1) wild-type and knockout (ko) mice and compared their weight and fat mass loss, glucose tolerance, food intake, and food preference after surgery. NTSR1 ko mice had reduced initial anorexia and body fat loss. Additionally, NTSR1 ko mice had an attenuated reduction in fat preference following VSG. Results from this study suggest that NTSR1 signaling contributes to the potent effect of VSG to initially reduce food intake following VSG surgeries and potentially also on the effects on macronutrient selection induced by VSG. However, maintenance of long-term weight loss after VSG requires signals in addition to NT.
KW - Fat preference
KW - Food intake
KW - Neurotensin
KW - Vertical sleeve gastrectomy
U2 - 10.1210/endocr/bqab130
DO - 10.1210/endocr/bqab130
M3 - Journal article
C2 - 34190328
AN - SCOPUS:85112580320
VL - 162
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0013-7227
IS - 9
M1 - bqab130
ER -
ID: 280667260