Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression

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Standard

Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression. / Bartels, Emil D.; Christoffersen, Christina; Lindholm, Marie W.; Nielsen, Lars B.

I: Circulation Research, Bind 117, 2015, s. 933-942.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Bartels, ED, Christoffersen, C, Lindholm, MW & Nielsen, LB 2015, 'Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression', Circulation Research, bind 117, s. 933-942. https://doi.org/10.1161/CIRCRESAHA.115.307182

APA

Bartels, E. D., Christoffersen, C., Lindholm, M. W., & Nielsen, L. B. (2015). Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression. Circulation Research, 117, 933-942. https://doi.org/10.1161/CIRCRESAHA.115.307182

Vancouver

Bartels ED, Christoffersen C, Lindholm MW, Nielsen LB. Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression. Circulation Research. 2015;117:933-942. https://doi.org/10.1161/CIRCRESAHA.115.307182

Author

Bartels, Emil D. ; Christoffersen, Christina ; Lindholm, Marie W. ; Nielsen, Lars B. / Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression. I: Circulation Research. 2015 ; Bind 117. s. 933-942.

Bibtex

@article{757c59f8c95241ee868442f0c1337d99,
title = "Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression",
abstract = "Rationale: Plasma cholesterol lowering is beneficial in patients with atherosclerosis. However, it is unknown how it affects entry and degradation of low-density lipoprotein (LDL) particles in the lesioned arterial wall.Objective: We studied the effect of lipid-lowering therapy on LDL permeability and degradation of LDL particles in atherosclerotic aortas of mice by measuring the accumulation of iodinated LDL particles in the arterial wall.Methods and Results: Cholesterol-fed, LDL receptor–deficient mice were treated with either an anti-Apob antisense oligonucleotide or a mismatch control antisense oligonucleotide once a week for 1 or 4 weeks before injection with preparations of iodinated LDL particles. The anti-Apob antisense oligonucleotide reduced plasma cholesterol by ≈90%. The aortic LDL permeability and degradation rates of newly entered LDL particles were reduced by ≈50% and ≈85% already after 1 week of treatment despite an unchanged pool size of aortic iodinated LDL particles. In contrast, the size, foam cell content, and aortic pool size of iodinated LDL particles of aortic atherosclerotic plaques were not reduced until after 4 weeks of treatment with the anti-Apob antisense oligonucleotide.Conclusions: Improved endothelial barrier function toward the entry of plasma LDL particles and diminished aortic degradation of the newly entered LDL particles precede plaque regression.",
author = "Bartels, {Emil D.} and Christina Christoffersen and Lindholm, {Marie W.} and Nielsen, {Lars B}",
year = "2015",
doi = "10.1161/CIRCRESAHA.115.307182",
language = "English",
volume = "117",
pages = "933--942",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "AHA/ASA",

}

RIS

TY - JOUR

T1 - Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression

AU - Bartels, Emil D.

AU - Christoffersen, Christina

AU - Lindholm, Marie W.

AU - Nielsen, Lars B

PY - 2015

Y1 - 2015

N2 - Rationale: Plasma cholesterol lowering is beneficial in patients with atherosclerosis. However, it is unknown how it affects entry and degradation of low-density lipoprotein (LDL) particles in the lesioned arterial wall.Objective: We studied the effect of lipid-lowering therapy on LDL permeability and degradation of LDL particles in atherosclerotic aortas of mice by measuring the accumulation of iodinated LDL particles in the arterial wall.Methods and Results: Cholesterol-fed, LDL receptor–deficient mice were treated with either an anti-Apob antisense oligonucleotide or a mismatch control antisense oligonucleotide once a week for 1 or 4 weeks before injection with preparations of iodinated LDL particles. The anti-Apob antisense oligonucleotide reduced plasma cholesterol by ≈90%. The aortic LDL permeability and degradation rates of newly entered LDL particles were reduced by ≈50% and ≈85% already after 1 week of treatment despite an unchanged pool size of aortic iodinated LDL particles. In contrast, the size, foam cell content, and aortic pool size of iodinated LDL particles of aortic atherosclerotic plaques were not reduced until after 4 weeks of treatment with the anti-Apob antisense oligonucleotide.Conclusions: Improved endothelial barrier function toward the entry of plasma LDL particles and diminished aortic degradation of the newly entered LDL particles precede plaque regression.

AB - Rationale: Plasma cholesterol lowering is beneficial in patients with atherosclerosis. However, it is unknown how it affects entry and degradation of low-density lipoprotein (LDL) particles in the lesioned arterial wall.Objective: We studied the effect of lipid-lowering therapy on LDL permeability and degradation of LDL particles in atherosclerotic aortas of mice by measuring the accumulation of iodinated LDL particles in the arterial wall.Methods and Results: Cholesterol-fed, LDL receptor–deficient mice were treated with either an anti-Apob antisense oligonucleotide or a mismatch control antisense oligonucleotide once a week for 1 or 4 weeks before injection with preparations of iodinated LDL particles. The anti-Apob antisense oligonucleotide reduced plasma cholesterol by ≈90%. The aortic LDL permeability and degradation rates of newly entered LDL particles were reduced by ≈50% and ≈85% already after 1 week of treatment despite an unchanged pool size of aortic iodinated LDL particles. In contrast, the size, foam cell content, and aortic pool size of iodinated LDL particles of aortic atherosclerotic plaques were not reduced until after 4 weeks of treatment with the anti-Apob antisense oligonucleotide.Conclusions: Improved endothelial barrier function toward the entry of plasma LDL particles and diminished aortic degradation of the newly entered LDL particles precede plaque regression.

U2 - 10.1161/CIRCRESAHA.115.307182

DO - 10.1161/CIRCRESAHA.115.307182

M3 - Journal article

C2 - 26358193

VL - 117

SP - 933

EP - 942

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

ER -

ID: 144297758