Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

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Standard

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. / Mandrup-Poulsen, T; Bendtzen, K; Nerup, J; Dinarello, C A; Svenson, M; Nielsen, Jens Høiriis.

I: Diabetologia, Bind 29, Nr. 1, 01.1986, s. 63-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mandrup-Poulsen, T, Bendtzen, K, Nerup, J, Dinarello, CA, Svenson, M & Nielsen, JH 1986, 'Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans', Diabetologia, bind 29, nr. 1, s. 63-7.

APA

Mandrup-Poulsen, T., Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M., & Nielsen, J. H. (1986). Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia, 29(1), 63-7.

Vancouver

Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M, Nielsen JH. Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia. 1986 jan;29(1):63-7.

Author

Mandrup-Poulsen, T ; Bendtzen, K ; Nerup, J ; Dinarello, C A ; Svenson, M ; Nielsen, Jens Høiriis. / Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. I: Diabetologia. 1986 ; Bind 29, Nr. 1. s. 63-7.

Bibtex

@article{ef87fb9a324e40db909602c7bb9d94cf,
title = "Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans",
abstract = "Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88{\%} inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31{\%} and 8{\%} respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.",
keywords = "Animals, Glucagon, Humans, Insulin, Interleukin-1, Islets of Langerhans, Male, Rats, Rats, Inbred Strains",
author = "T Mandrup-Poulsen and K Bendtzen and J Nerup and Dinarello, {C A} and M Svenson and Nielsen, {Jens H{\o}iriis}",
year = "1986",
month = "1",
language = "English",
volume = "29",
pages = "63--7",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

AU - Mandrup-Poulsen, T

AU - Bendtzen, K

AU - Nerup, J

AU - Dinarello, C A

AU - Svenson, M

AU - Nielsen, Jens Høiriis

PY - 1986/1

Y1 - 1986/1

N2 - Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.

AB - Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.

KW - Animals

KW - Glucagon

KW - Humans

KW - Insulin

KW - Interleukin-1

KW - Islets of Langerhans

KW - Male

KW - Rats

KW - Rats, Inbred Strains

M3 - Journal article

VL - 29

SP - 63

EP - 67

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 1

ER -

ID: 47975100