A simple method to ensure homogeneous drug distribution during intrarenal infusion

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A simple method to ensure homogeneous drug distribution during intrarenal infusion. / Postnov, Dmitry D; Salomonsson, Max; Sorensen, Charlotte M; Sosnovtseva, Olga V.

I: American Journal of Physiology: Renal Physiology, Bind 312, Nr. 3, 09.03.2017, s. F543-F548.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Postnov, DD, Salomonsson, M, Sorensen, CM & Sosnovtseva, OV 2017, 'A simple method to ensure homogeneous drug distribution during intrarenal infusion', American Journal of Physiology: Renal Physiology, bind 312, nr. 3, s. F543-F548. https://doi.org/10.1152/ajprenal.00417.2016

APA

Postnov, D. D., Salomonsson, M., Sorensen, C. M., & Sosnovtseva, O. V. (2017). A simple method to ensure homogeneous drug distribution during intrarenal infusion. American Journal of Physiology: Renal Physiology, 312(3), F543-F548. https://doi.org/10.1152/ajprenal.00417.2016

Vancouver

Postnov DD, Salomonsson M, Sorensen CM, Sosnovtseva OV. A simple method to ensure homogeneous drug distribution during intrarenal infusion. American Journal of Physiology: Renal Physiology. 2017 mar. 9;312(3):F543-F548. https://doi.org/10.1152/ajprenal.00417.2016

Author

Postnov, Dmitry D ; Salomonsson, Max ; Sorensen, Charlotte M ; Sosnovtseva, Olga V. / A simple method to ensure homogeneous drug distribution during intrarenal infusion. I: American Journal of Physiology: Renal Physiology. 2017 ; Bind 312, Nr. 3. s. F543-F548.

Bibtex

@article{f7b14f237987460ca4c1807780968943,

title = "A simple method to ensure homogeneous drug distribution during intrarenal infusion",

abstract = "Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method we use laser speckle imaging and renal artery flowmetry. The results show that, compared to the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.",

author = "Postnov, {Dmitry D} and Max Salomonsson and Sorensen, {Charlotte M} and Sosnovtseva, {Olga V}",

note = "Copyright {\textcopyright} 2016, American Journal of Physiology-Renal Physiology.",

year = "2017",

month = mar,

day = "9",

doi = "10.1152/ajprenal.00417.2016",

language = "English",

volume = "312",

pages = "F543--F548",

journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",

issn = "1931-857X",

publisher = "American Physiological Society",

number = "3",

}

RIS

TY - JOUR

T1 - A simple method to ensure homogeneous drug distribution during intrarenal infusion

AU - Postnov, Dmitry D

AU - Salomonsson, Max

AU - Sorensen, Charlotte M

AU - Sosnovtseva, Olga V

PY - 2017/3/9

Y1 - 2017/3/9

N2 - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method we use laser speckle imaging and renal artery flowmetry. The results show that, compared to the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.

AB - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method we use laser speckle imaging and renal artery flowmetry. The results show that, compared to the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.

U2 - 10.1152/ajprenal.00417.2016

DO - 10.1152/ajprenal.00417.2016

M3 - Journal article

C2 - 27881397

VL - 312

SP - F543-F548

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 3

ER -

ID: 169641381

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