18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy

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Standard

18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy. / Simón, Marina; Jørgensen, Jesper Tranekjær; Norregaard, Kamilla; Kjaer, Andreas.

I: Scientific Reports, Bind 10, Nr. 1, 7595, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Simón, M, Jørgensen, JT, Norregaard, K & Kjaer, A 2020, '18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy', Scientific Reports, bind 10, nr. 1, 7595. https://doi.org/10.1038/s41598-020-64617-w

APA

Simón, M., Jørgensen, J. T., Norregaard, K., & Kjaer, A. (2020). 18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy. Scientific Reports, 10(1), [7595]. https://doi.org/10.1038/s41598-020-64617-w

Vancouver

Simón M, Jørgensen JT, Norregaard K, Kjaer A. 18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy. Scientific Reports. 2020;10(1). 7595. https://doi.org/10.1038/s41598-020-64617-w

Author

Simón, Marina ; Jørgensen, Jesper Tranekjær ; Norregaard, Kamilla ; Kjaer, Andreas. / 18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy. I: Scientific Reports. 2020 ; Bind 10, Nr. 1.

Bibtex

@article{4da77ed429b14d738bc2a88404db39e9,
title = "18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy",
abstract = "Nanoparticle-mediated photothermal cancer therapy (PTT) is a treatment which creates localized damage to tumors via nanoparticles that generate heat when irradiated with near infrared light. Substantial work has been dedicated to developing efficient heat-transducing nanoparticles that can be delivered systemically to the tumor. However, less attention has been given to clinically relevant assessment methods of treatment outcome that could be used for personalizing the therapy. Here, we compare 18F-FDG positron emission tomography combined with computed tomography (PET/CT) and diffusion-weighted imaging (DWI) for early evaluation and prognosis of PTT in tumor-bearing mice using silica-gold nanoshells (NS). The NS-treated mice experienced inhibited tumor growth and significantly prolonged survival compared to control mice. One day after PTT, PET/CT and DWI scans showed a decrease in tumor 18F-FDG uptake of ~90% and an increase of ~50% in apparent diffusion coefficient (ADC) values respectively, compared to baseline. No significant changes were observed for control groups. Additionally, the changes in 18F-FDG uptake and ADC values correlated significantly with survival, demonstrating that both methods can be used for early evaluation of PTT although 18F-FDG PET/CT showed the strongest prognostic value. Based on these results, both modalities should be considered for therapy monitoring of PTT when clinically translated.",
keywords = "Animals, Biopsy, Combined Modality Therapy, Diffusion Magnetic Resonance Imaging, Disease Models, Animal, Fluorodeoxyglucose F18, Humans, Hyperthermia, Induced/methods, Immunohistochemistry, Mice, Neoplasms/diagnostic imaging, Phototherapy/methods, Positron Emission Tomography Computed Tomography/methods, Positron-Emission Tomography, Prognosis, Theranostic Nanomedicine, Treatment Outcome, Xenograft Model Antitumor Assays",
author = "Marina Sim{\'o}n and J{\o}rgensen, {Jesper Tranekj{\ae}r} and Kamilla Norregaard and Andreas Kjaer",
year = "2020",
doi = "10.1038/s41598-020-64617-w",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - 18F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy

AU - Simón, Marina

AU - Jørgensen, Jesper Tranekjær

AU - Norregaard, Kamilla

AU - Kjaer, Andreas

PY - 2020

Y1 - 2020

N2 - Nanoparticle-mediated photothermal cancer therapy (PTT) is a treatment which creates localized damage to tumors via nanoparticles that generate heat when irradiated with near infrared light. Substantial work has been dedicated to developing efficient heat-transducing nanoparticles that can be delivered systemically to the tumor. However, less attention has been given to clinically relevant assessment methods of treatment outcome that could be used for personalizing the therapy. Here, we compare 18F-FDG positron emission tomography combined with computed tomography (PET/CT) and diffusion-weighted imaging (DWI) for early evaluation and prognosis of PTT in tumor-bearing mice using silica-gold nanoshells (NS). The NS-treated mice experienced inhibited tumor growth and significantly prolonged survival compared to control mice. One day after PTT, PET/CT and DWI scans showed a decrease in tumor 18F-FDG uptake of ~90% and an increase of ~50% in apparent diffusion coefficient (ADC) values respectively, compared to baseline. No significant changes were observed for control groups. Additionally, the changes in 18F-FDG uptake and ADC values correlated significantly with survival, demonstrating that both methods can be used for early evaluation of PTT although 18F-FDG PET/CT showed the strongest prognostic value. Based on these results, both modalities should be considered for therapy monitoring of PTT when clinically translated.

AB - Nanoparticle-mediated photothermal cancer therapy (PTT) is a treatment which creates localized damage to tumors via nanoparticles that generate heat when irradiated with near infrared light. Substantial work has been dedicated to developing efficient heat-transducing nanoparticles that can be delivered systemically to the tumor. However, less attention has been given to clinically relevant assessment methods of treatment outcome that could be used for personalizing the therapy. Here, we compare 18F-FDG positron emission tomography combined with computed tomography (PET/CT) and diffusion-weighted imaging (DWI) for early evaluation and prognosis of PTT in tumor-bearing mice using silica-gold nanoshells (NS). The NS-treated mice experienced inhibited tumor growth and significantly prolonged survival compared to control mice. One day after PTT, PET/CT and DWI scans showed a decrease in tumor 18F-FDG uptake of ~90% and an increase of ~50% in apparent diffusion coefficient (ADC) values respectively, compared to baseline. No significant changes were observed for control groups. Additionally, the changes in 18F-FDG uptake and ADC values correlated significantly with survival, demonstrating that both methods can be used for early evaluation of PTT although 18F-FDG PET/CT showed the strongest prognostic value. Based on these results, both modalities should be considered for therapy monitoring of PTT when clinically translated.

KW - Animals

KW - Biopsy

KW - Combined Modality Therapy

KW - Diffusion Magnetic Resonance Imaging

KW - Disease Models, Animal

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Hyperthermia, Induced/methods

KW - Immunohistochemistry

KW - Mice

KW - Neoplasms/diagnostic imaging

KW - Phototherapy/methods

KW - Positron Emission Tomography Computed Tomography/methods

KW - Positron-Emission Tomography

KW - Prognosis

KW - Theranostic Nanomedicine

KW - Treatment Outcome

KW - Xenograft Model Antitumor Assays

U2 - 10.1038/s41598-020-64617-w

DO - 10.1038/s41598-020-64617-w

M3 - Journal article

C2 - 32371864

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7595

ER -

ID: 256521377