Research projects – University of Copenhagen

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Research projects - ongoing

Acronym

Title

PI 

Collaborators 

AARHUS

Vitamin B3 supplements for twelve weeks in Obese. Clamp study.

SL 

JWH. FD, JT, SDS

METAPREDICT

Developing predictors of the health benefits of exercise for individuals.

JWH

SL, FD, TLD MHi, JD, SDS

HFD-OX

Oxidative stress markers in muscle following HFD and training

FD RK, CPG, CNH

PIGS

Mitochondrial function in liver, heart and muscle.

SL

LBC, JWH, FD, TLD

IFAST mito

The effect of intermittent fasting on ROS production and mitochondrial respiration in patients with type 2 diabetes

FD

SL, SS, JWH, AI

LIFESTAT

Living with Statins.
- Training, Q10 and Statins[longitudinal] (n=100)
- Mylagia [cross-sectional] (n=60)www.lifestat.dk

FD

JWH, SL, TLD, THM, ABK

UBBERUP

 The factors that determine maintenance of lifestyle modifications and weight loss.
www.ubberup.dk

JWH

SDJ, SL, FD, MGN, CS, CP, KBC, MD, KH, SODJ, SOL

HIT OLD

The effect of HIT on aerobic and metabolic fitness (one part in writing, two parts for analysis Mitochondria + Lipids).

JWH

DS, SL, KBC, CS, SD

 ROS and HIT

The effect of HIT on ROS production.

SL

RK, JWH, FD, MG

GASMITO, MITOBOLISM and MITOAGE

Skeletal muscle mitochondrial network dynamics during obesity, inmobilization and training.

CPG

AVH, MG, MTL, MHa, JWH, ALJ, MDK

Lipid in aging 

The influence of age and training on muscle lipids. DAG and Ceramide content; effect of age. Biopsies waiting for analysis, WB in progress   

JWH 

DK, FD, CPG 

KINETIC

IMTG and glycogen stores quantity and quality VS IS

CPG

AGC, FD, JWH, SL

GASMITO

Liver analysis - Ceramide and DAGS

JWH

FD, MTL, MHa, CPG, ALJ, MDK

EPO - acute

Double blind infusion of EPO / Saline; effect on mito resp., muscle signalling.

JWH

SDS, THM, SL, JF, RS, FD

MUFI box

Validation and methods study of mito resp; In men two legs, two sites

SL

RS, JWH, THM, SL, JF, FD

FASTMAX

Fasting or CHO meals in four repeated FATMAX on two separate days. N=6, lacking two subjects?

JWH

JF, SDJ, SDS, SL, D

DIMITOS

Glutathione supplementation in patients with type 2 diabetes and matched controls

SL

SDS, MA, FD, JWH

HVIDOVRE

Liver and adipose samples from Hvidovre - respiration

FD

MA, JWH, SL

KO ampkα2

AMPK KO inducible method

SL

JW, FD, JWH

 

Research projects - In writing

Acronym 

Title

PI 

Collaborators 

Iron man

Fat max and performance in 68 men that participated in KMD CPH august 2016

JWH

JF, SDJ, SDS, SL, FD

IFAST

The effect of intermittent fasting on glucose homeostasis in patients with type 2 diabetes.

FD

SS, JWH, AI, HRH

GASMITO

The effect of gastric bypass surgery on glucose and lipid metabolism and
mitochondrial respiration.

FD

MTL, MHa, CPG, JWH, ALJ, MDK, SL

GASMITO

The effect of gastric bypass surgery on adipose tissue, liver and muscle macrophage inflammation.

CPG

FD, MDK, MTL, MHa, JWH, ALJ

SPAIN MET S

The effect of training and N-3 on muscle in MET S patients.

JWH

VE, AGG, RM, FD

miR-LIFE

Influence of changes in levels of activity and weight loss on the expression of miRNAs in human adipose and muscle tissue. 

FD, JWH

MMK, CNH, MTL, JBJ, AV, JB

STATIN I

Effect of statins on lipase and perilepin expression.

JWH

FD, AVH, SL

STATIN II

The effect of 2 weeks statin treatment on muscle strength and mitochondrial function.

FD

JWH, SL, CNH

GREENLAND

The influence of prolonged low intensity exercise on metabolism.

JWH

RB, AVH, TMA

HR-MAX

Influence of CVP and maximal heart rate in trained and untrained individuals.

JWH

RB, JC, FP. MH

MITOBOLISM

The effects of immobilization, exercise and training on skeletal muscle lipid
metabolism and mitochondrial function in young and elderly healthy men.

FD/JWH 

AVH, MG, CPG, CW

Local Kick

The influence of graded exercise on VLDL uptake.

JWH 

FD, BS, LBN, EB, MP

LEPTIN RESP 

The in vitro influence of leptin on respirometry. 

JWH 

FD, SL, MTL, AGG 

POSTOBESE 

The influence of obesity on adipose tissue macrophage inflammation.

JWH 

CPG, TP, BS, IA, PA, SL  

HIGH FAT DIET II 

The effect of HFD and training on mitochondrial respiration.

FD 

MSK, CPG, JWH, CNH

DONOR (Kvinde)

The effect of a single donation of blood on maximal oxygen uptake and
performance. 

JWH 

FD, AKZ, JG, KM, NLK  

NORDKAP

The effect of prolonged low intensity cycling on metabolism and energy
balance. 

JWH 

FD, PRA, KKC, THM, TMA, AGG, CPG, AS, HR, NM, MRL

TRI-FATOX

The influence of training on maximal fat oxidation during running and cycling.
 

JWH

TB

GLP-DEPLETION

Investigate the use of different energy pools in response to exhausting exercise and protein translocation of related enzymes. 

CPG

JWH, FD, AGC, EMGA, FLC

ADP sensitivity

Mitochondrial ADP sensitivity in adipose and muscle tissue after 6 weeks of High Intensity
Training.

SL

TLD, MHi, JWH, FD

GIP, GLP1 AFTER HIT

The effects of HIT on GIP and GLP-1

JWH

MHi, TLD, MTL, SL, (JK), FD, JWH

Mito O2

Investigating the effect of different O2 concentrations on mitochondrial function. 

FD

SL, JWH

KINETIC

Skeletal muscle glycogen and lipid stores in lean, obese and matched obese-T2D.

CPG

EMGA, FLC

Mito-met

Method paper

SL

RK, MG, SL, TLD, MTL, JWH, FD

HIIT T2DM

High Intensity Interval Training and insulin sensitivity in skeletal muscle in
patients with Type 2 diabetes.

FD

JWH, CBG, SS, AI, NBA, MBN, HHHP, CNH

Research projects - in planning

Acronym

Title

PI 

Collaborators 

PALERMO

Young & Old biking to Plaermo

JWH 

FD +++

BIO-AGE

PhD study on biological age; two cross-sectional studies and one longitudinal

JWH

FASTMAX - women

JWH

T2DLIS

Lifestyle intervention T2DM. Ubberup.

JWH

SD

OVERFEED

Chronic overfeeding and muscle disuse – effect on skeletal muscle mitochondrial and lipid stores quality and link to whole body insulin sensitivity.