Research themes – University of Copenhagen

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English > Research > Translational Metabolic Physiology > Research themes

Research themes

We are currently working in different research themes:

The role of pancreatic and intestinal hormones in bone physiology

Focuses on pancreatic and intestinal hormones and their role in intestinal and bone physiology. This includes both animal (mice, rat and pig) studies as well as human studies (gastric bypass patients, diabetic patients and healthy controls). In addition, we are continuously working on assay development to improve our unique spectrum of assays for measuring gastrointestinal hormones.

For further information regarding the role of pancreatic and intestinal hormones in bone physiology, please contact Bolette Hartmann.

Clinical translation of diabetes and obesity

Focuses on providing insights into the biological function in humans of the genes behind the strong genetic component of obesity and diabetes, as well as into the treatment potential. Clinically targeting these dysfunctionalities will with time improve the prevention, diagnosis and treatment of type-2 diabetes and obesity. Therefore, the overall aim is to clinically translate knowledge of rare genetic variants in genes encoding beta-cell and appetite regulating proteins into actions of personalised prevention, diagnosis and treatment of obesity and diabetes.

For further information regarding clinical translation of diabetes and obesity, please contact Signe Sørensen Torekov.

Metabolism and physiology of enteroendocrine hormones

Centers on the degradation and metabolism of the entero-pancreatic hormones (GLP-1, GLP-2, GIP, PYY, glucagon), the physiology and pathophysiology of the incretin hormones, and the therapeutic applications of the incretin hormones, GLP-1 analogues and DPP-4 inhibitors in the treatment of type 2 diabetes.

For further information regarding metabolism and physiology of enteroendocrine hormones, please contact Carolyn Deacon.

Integration of the gut in human glucose metabolism and its role in diabetes and obesity

Centres on the pathophysiology of type 2 diabetes (with focus on glucagon and the gut-derived incretin hormones), obesity, regulation of appetite and food intake and utilization of incretins as therapeutics. Integration of the gut (including enteroendocrinology, microflora and bile acid biology) in the understanding of human glucose metabolism and its role in type 2 diabetic pathophysiology is our main focus.

For further information regarding integration of the gut in human glucose metabolism and its role in diabetes and obesity, please contact Filip Krag Knop.

For other contact information please see Contact or Staff.