Renal Hemodynamics – University of Copenhagen

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English > Research > Renal Hemodynamics

The kidney regulates salt and water excretion and therefore kidney function is crucial in the regulation of blood pressure.

In the western world hypertension is a major health problem which has fatal consequences such as myocardial infarction, stroke and renal failure. The mechanisms behind the development and maintenance of hypertension are largely unknown despite intense research.

We suggest that changes in kidney function are involved in development of hypertension. This is supported by the fact that transplantation of kidneys from hypertensive patiens to normotensive patiens makes recipients hypertensive and vice versa.

We investigate the mechanisms regulating the excretory function of the kidney. This includes control of renal blood flow (RBF), glomerular filtration rate (GFR) and the renin-angiotensin system. We focus on intercellular communication via gap junctions, vascular regulation via K+ and Ca2+ channels, the sympathetic nervous system and changes in renal autoregulation

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